Efficacy of platelet rich plasma for acceleration of healing in chronic wounds; research article
Objective: To compare the standard dressing with normal saline with platelet-rich plasma for acceleration of healing in patients with chronic wounds. Method: The study was conducted at the Department of Plastic and Reconstructive Surgery, Dow University of Health Sciences and Dr K.M. Ruth Pfau Ci...
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| Format: | Article |
| Language: | English |
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Pakistan Medical Association
2024-08-01
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| Series: | Journal of the Pakistan Medical Association |
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| Online Access: | https://jpma.org.pk/index.php/public_html/article/view/10719 |
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| author | Mujtuba Pervez Khan Hyder Ali Suneel Kumar |
| author_facet | Mujtuba Pervez Khan Hyder Ali Suneel Kumar |
| author_sort | Mujtuba Pervez Khan |
| collection | DOAJ |
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Objective: To compare the standard dressing with normal saline with platelet-rich plasma for acceleration of healing in patients with chronic wounds.
Method: The study was conducted at the Department of Plastic and Reconstructive Surgery, Dow University of Health Sciences and Dr K.M. Ruth Pfau Civil Hospital, Karachi, from April 1, 2019, to March 31, 2020, and comprised patients of either gender aged 18-60 years with arterial ulcers on the lower limb with dimension of wound <10cm2, haemoglobin >10g/dl and platelet count >150x109/L. The patients were randomised into control group A, which received conventional treatment of dressing with normal saline, and intervention group B, which received daily dressings with normal saline and weekly application of platelet-rich plasma. The procedure was repeated every week for 3 weeks. Bates Jensen wound assessment tool was used to assess the final outcome. Data was analysed using SPSS 20.
Results: Of the 98 patients, with mean age 41.68±11.03 years, there were 49(50%) in group A; 45(91.8%) males and 4(8.2%) females with overall mean age 40.10±10.8 years. The other 49(50%) patients were in group B; 39(79.6%) males and 10(20.4%) females with overall mean age 43.27±11.1 years (p>0.05). Mean wound assessment score of group B patients decreased significantly compared to group A (p=0.002).
Conclusion: Platelet-rich plasma treatment showed better performance in accelerating healing of chronic arterial wounds compared to the standard treatment of daily dressing with normal saline.
Key Words: Wounds, Platelet-rich plasma.
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| format | Article |
| id | doaj-art-9523524e90e04bd5ae068ffe8894aaf0 |
| institution | Kabale University |
| issn | 0030-9982 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Pakistan Medical Association |
| record_format | Article |
| series | Journal of the Pakistan Medical Association |
| spelling | doaj-art-9523524e90e04bd5ae068ffe8894aaf02025-08-20T03:39:57ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822024-08-0174910.47391/JPMA.10719Efficacy of platelet rich plasma for acceleration of healing in chronic wounds; research articleMujtuba Pervez Khan0Hyder Ali1Suneel Kumar2Department of Plastic Surgery, Dow University of Health Sciences, Karachi, PakistanDepartment of Plastic Surgery, Dow University of Health Sciences, Karachi, PakistanDepartment of Plastic Surgery, Dow University of Health Sciences, Karachi, Pakistan Objective: To compare the standard dressing with normal saline with platelet-rich plasma for acceleration of healing in patients with chronic wounds. Method: The study was conducted at the Department of Plastic and Reconstructive Surgery, Dow University of Health Sciences and Dr K.M. Ruth Pfau Civil Hospital, Karachi, from April 1, 2019, to March 31, 2020, and comprised patients of either gender aged 18-60 years with arterial ulcers on the lower limb with dimension of wound <10cm2, haemoglobin >10g/dl and platelet count >150x109/L. The patients were randomised into control group A, which received conventional treatment of dressing with normal saline, and intervention group B, which received daily dressings with normal saline and weekly application of platelet-rich plasma. The procedure was repeated every week for 3 weeks. Bates Jensen wound assessment tool was used to assess the final outcome. Data was analysed using SPSS 20. Results: Of the 98 patients, with mean age 41.68±11.03 years, there were 49(50%) in group A; 45(91.8%) males and 4(8.2%) females with overall mean age 40.10±10.8 years. The other 49(50%) patients were in group B; 39(79.6%) males and 10(20.4%) females with overall mean age 43.27±11.1 years (p>0.05). Mean wound assessment score of group B patients decreased significantly compared to group A (p=0.002). Conclusion: Platelet-rich plasma treatment showed better performance in accelerating healing of chronic arterial wounds compared to the standard treatment of daily dressing with normal saline. Key Words: Wounds, Platelet-rich plasma. https://jpma.org.pk/index.php/public_html/article/view/10719WoundsPlatelet rich plasma |
| spellingShingle | Mujtuba Pervez Khan Hyder Ali Suneel Kumar Efficacy of platelet rich plasma for acceleration of healing in chronic wounds; research article Journal of the Pakistan Medical Association Wounds Platelet rich plasma |
| title | Efficacy of platelet rich plasma for acceleration of healing in chronic wounds; research article |
| title_full | Efficacy of platelet rich plasma for acceleration of healing in chronic wounds; research article |
| title_fullStr | Efficacy of platelet rich plasma for acceleration of healing in chronic wounds; research article |
| title_full_unstemmed | Efficacy of platelet rich plasma for acceleration of healing in chronic wounds; research article |
| title_short | Efficacy of platelet rich plasma for acceleration of healing in chronic wounds; research article |
| title_sort | efficacy of platelet rich plasma for acceleration of healing in chronic wounds research article |
| topic | Wounds Platelet rich plasma |
| url | https://jpma.org.pk/index.php/public_html/article/view/10719 |
| work_keys_str_mv | AT mujtubapervezkhan efficacyofplateletrichplasmaforaccelerationofhealinginchronicwoundsresearcharticle AT hyderali efficacyofplateletrichplasmaforaccelerationofhealinginchronicwoundsresearcharticle AT suneelkumar efficacyofplateletrichplasmaforaccelerationofhealinginchronicwoundsresearcharticle |