Inflammatory Cytokine Signaling during Development of Pancreatic and Prostate Cancers
Inflammation is essential for many diseases including cancer. Activation and recruitment of immune cells during inflammation result in a cytokine- and chemokine-enriched cell environment, which affects cancer development. Since each type of cancer has its unique tumor environment, effects of cytokin...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/7979637 |
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| _version_ | 1850209581090734080 |
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| author | Geou-Yarh Liou |
| author_facet | Geou-Yarh Liou |
| author_sort | Geou-Yarh Liou |
| collection | DOAJ |
| description | Inflammation is essential for many diseases including cancer. Activation and recruitment of immune cells during inflammation result in a cytokine- and chemokine-enriched cell environment, which affects cancer development. Since each type of cancer has its unique tumor environment, effects of cytokines from different sources such as tumor-infiltrating immune cells, stromal cells, endothelial cells, and cancer cells on cancer development can be quite complex. In this review, how immune cells contribute to tumorigenesis of pancreatic and prostate cancers through their secreted cytokines is discussed. In addition, the cytokine signaling that tumor cells of pancreatic and prostate cancers utilize to benefit their own survival is delineated. |
| format | Article |
| id | doaj-art-9520af6475be414b9dd2f47eb71f4186 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-9520af6475be414b9dd2f47eb71f41862025-08-20T02:09:58ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/79796377979637Inflammatory Cytokine Signaling during Development of Pancreatic and Prostate CancersGeou-Yarh Liou0Center for Cancer Research & Therapeutic Development and Department of Biological Sciences, Clark Atlanta University, 223 James P. Brawley Drive SW, Atlanta, GA 30314, USAInflammation is essential for many diseases including cancer. Activation and recruitment of immune cells during inflammation result in a cytokine- and chemokine-enriched cell environment, which affects cancer development. Since each type of cancer has its unique tumor environment, effects of cytokines from different sources such as tumor-infiltrating immune cells, stromal cells, endothelial cells, and cancer cells on cancer development can be quite complex. In this review, how immune cells contribute to tumorigenesis of pancreatic and prostate cancers through their secreted cytokines is discussed. In addition, the cytokine signaling that tumor cells of pancreatic and prostate cancers utilize to benefit their own survival is delineated.http://dx.doi.org/10.1155/2017/7979637 |
| spellingShingle | Geou-Yarh Liou Inflammatory Cytokine Signaling during Development of Pancreatic and Prostate Cancers Journal of Immunology Research |
| title | Inflammatory Cytokine Signaling during Development of Pancreatic and Prostate Cancers |
| title_full | Inflammatory Cytokine Signaling during Development of Pancreatic and Prostate Cancers |
| title_fullStr | Inflammatory Cytokine Signaling during Development of Pancreatic and Prostate Cancers |
| title_full_unstemmed | Inflammatory Cytokine Signaling during Development of Pancreatic and Prostate Cancers |
| title_short | Inflammatory Cytokine Signaling during Development of Pancreatic and Prostate Cancers |
| title_sort | inflammatory cytokine signaling during development of pancreatic and prostate cancers |
| url | http://dx.doi.org/10.1155/2017/7979637 |
| work_keys_str_mv | AT geouyarhliou inflammatorycytokinesignalingduringdevelopmentofpancreaticandprostatecancers |