Life-Threatening Adenovirus Infections in the Setting of the Immunocompromised Allogeneic Stem Cell Transplant Patients
A single institution case series of adenovirus infections after allogeneic hematopoietic stem cell transplantation is presented to highlight the consideration for adenovirus infections as an etiology in patients with rapid hepatic or other sudden organ deterioration in the setting of apparent GVHD s...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2010/601548 |
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| author | Cedar J. Fowler Jennifer Dunlap Darcy Troyer Peter Stenzel Elliot Epner Richard T. Maziarz |
| author_facet | Cedar J. Fowler Jennifer Dunlap Darcy Troyer Peter Stenzel Elliot Epner Richard T. Maziarz |
| author_sort | Cedar J. Fowler |
| collection | DOAJ |
| description | A single institution case series of adenovirus infections after allogeneic hematopoietic stem cell transplantation is presented to highlight the consideration for adenovirus infections as an etiology in patients with rapid hepatic or other sudden organ deterioration in the setting of apparent GVHD stabilization. The series also highlights that survival is limited with these infections often due in part to concomitant opportunistic infections. In addition, the pathophysiological events, such as GVHD and hepatic dysfunction, may complicate the clinical picture and delay therapy of an opportunistic infection. This is particularly true for adenoviral infections as they also have a distinct clinical picture in immunocompromised patients when compared to immune competent patients. Adenovirus infections also have the additional challenge that its treatment, cidofovir, has associated toxicities that can delay its administration. Recent developments has yielded an assay that can be used in the early detection and for serial determinations of adenovirus in patients with advanced GVHD, as well as a new therapeutic agent currently undergoing clinical trials. |
| format | Article |
| id | doaj-art-95199dcb9c5f44dbaaef72ff2af2642a |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-95199dcb9c5f44dbaaef72ff2af2642a2025-02-03T06:46:56ZengWileyAdvances in Hematology1687-91041687-91122010-01-01201010.1155/2010/601548601548Life-Threatening Adenovirus Infections in the Setting of the Immunocompromised Allogeneic Stem Cell Transplant PatientsCedar J. Fowler0Jennifer Dunlap1Darcy Troyer2Peter Stenzel3Elliot Epner4Richard T. Maziarz5Laboratory of Clinical Infectious Diseases—NIAID, National Institutes of Health, 9000 Rockville Pike MSC 1684, Bethesda, MD 20892-1684, USADepartment of Pathology, Oregon Health and Science University, 3181 SW. Sam Jackson Park Road, Portland, OR 97239, USAAdult Blood and Marrow Stem Cell Transplant Program, Oregon Health and Science University, 3181 SW. Sam Jackson Park Road, Portland, OR 97239, USADepartment of Pathology, Oregon Health and Science University, 3181 SW. Sam Jackson Park Road, Portland, OR 97239, USAPenn State Hershey Medical Center 500, University Drive, Hershey, PA 17033, USAAdult Blood and Marrow Stem Cell Transplant Program, Oregon Health and Science University, 3181 SW. Sam Jackson Park Road, Portland, OR 97239, USAA single institution case series of adenovirus infections after allogeneic hematopoietic stem cell transplantation is presented to highlight the consideration for adenovirus infections as an etiology in patients with rapid hepatic or other sudden organ deterioration in the setting of apparent GVHD stabilization. The series also highlights that survival is limited with these infections often due in part to concomitant opportunistic infections. In addition, the pathophysiological events, such as GVHD and hepatic dysfunction, may complicate the clinical picture and delay therapy of an opportunistic infection. This is particularly true for adenoviral infections as they also have a distinct clinical picture in immunocompromised patients when compared to immune competent patients. Adenovirus infections also have the additional challenge that its treatment, cidofovir, has associated toxicities that can delay its administration. Recent developments has yielded an assay that can be used in the early detection and for serial determinations of adenovirus in patients with advanced GVHD, as well as a new therapeutic agent currently undergoing clinical trials.http://dx.doi.org/10.1155/2010/601548 |
| spellingShingle | Cedar J. Fowler Jennifer Dunlap Darcy Troyer Peter Stenzel Elliot Epner Richard T. Maziarz Life-Threatening Adenovirus Infections in the Setting of the Immunocompromised Allogeneic Stem Cell Transplant Patients Advances in Hematology |
| title | Life-Threatening Adenovirus Infections in the Setting of the Immunocompromised Allogeneic Stem Cell Transplant Patients |
| title_full | Life-Threatening Adenovirus Infections in the Setting of the Immunocompromised Allogeneic Stem Cell Transplant Patients |
| title_fullStr | Life-Threatening Adenovirus Infections in the Setting of the Immunocompromised Allogeneic Stem Cell Transplant Patients |
| title_full_unstemmed | Life-Threatening Adenovirus Infections in the Setting of the Immunocompromised Allogeneic Stem Cell Transplant Patients |
| title_short | Life-Threatening Adenovirus Infections in the Setting of the Immunocompromised Allogeneic Stem Cell Transplant Patients |
| title_sort | life threatening adenovirus infections in the setting of the immunocompromised allogeneic stem cell transplant patients |
| url | http://dx.doi.org/10.1155/2010/601548 |
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