Molecular Mechanisms and Function Prediction of Long Noncoding RNA
The central dogma of gene expression considers RNA as the carrier of genetic information from DNA to protein. However, it has become more and more clear that RNA plays more important roles than simply being the information carrier. Recently, whole genome transcriptomic analyses have identified large...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/541786 |
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| _version_ | 1849404377934069760 |
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| author | Handong Ma Yun Hao Xinran Dong Qingtian Gong Jingqi Chen Jifeng Zhang Weidong Tian |
| author_facet | Handong Ma Yun Hao Xinran Dong Qingtian Gong Jingqi Chen Jifeng Zhang Weidong Tian |
| author_sort | Handong Ma |
| collection | DOAJ |
| description | The central dogma of gene expression considers RNA as the carrier of genetic information from DNA to protein. However, it has become more and more clear that RNA plays more important roles than simply being the information carrier. Recently, whole genome transcriptomic analyses have identified large numbers of dynamically expressed long noncoding RNAs (lncRNAs), many of which are involved in a variety of biological functions. Even so, the functions and molecular mechanisms of most lncRNAs still remain elusive. Therefore, it is necessary to develop computational methods to predict the function of lncRNAs in order to accelerate the study of lncRNAs. Here, we review the recent progress in the identification of lncRNAs, the molecular functions and mechanisms of lncRNAs, and the computational methods for predicting the function of lncRNAs. |
| format | Article |
| id | doaj-art-9519042c626d4b93b86e45d0fd73fdcb |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-9519042c626d4b93b86e45d0fd73fdcb2025-08-20T03:37:01ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/541786541786Molecular Mechanisms and Function Prediction of Long Noncoding RNAHandong Ma0Yun Hao1Xinran Dong2Qingtian Gong3Jingqi Chen4Jifeng Zhang5Weidong Tian6Institute of Biostatistics, School of Life Science, Fudan University, 220 Handan Road, Shanghai 2004333, ChinaInstitute of Biostatistics, School of Life Science, Fudan University, 220 Handan Road, Shanghai 2004333, ChinaInstitute of Biostatistics, School of Life Science, Fudan University, 220 Handan Road, Shanghai 2004333, ChinaInstitute of Biostatistics, School of Life Science, Fudan University, 220 Handan Road, Shanghai 2004333, ChinaInstitute of Biostatistics, School of Life Science, Fudan University, 220 Handan Road, Shanghai 2004333, ChinaInstitute of Biostatistics, School of Life Science, Fudan University, 220 Handan Road, Shanghai 2004333, ChinaInstitute of Biostatistics, School of Life Science, Fudan University, 220 Handan Road, Shanghai 2004333, ChinaThe central dogma of gene expression considers RNA as the carrier of genetic information from DNA to protein. However, it has become more and more clear that RNA plays more important roles than simply being the information carrier. Recently, whole genome transcriptomic analyses have identified large numbers of dynamically expressed long noncoding RNAs (lncRNAs), many of which are involved in a variety of biological functions. Even so, the functions and molecular mechanisms of most lncRNAs still remain elusive. Therefore, it is necessary to develop computational methods to predict the function of lncRNAs in order to accelerate the study of lncRNAs. Here, we review the recent progress in the identification of lncRNAs, the molecular functions and mechanisms of lncRNAs, and the computational methods for predicting the function of lncRNAs.http://dx.doi.org/10.1100/2012/541786 |
| spellingShingle | Handong Ma Yun Hao Xinran Dong Qingtian Gong Jingqi Chen Jifeng Zhang Weidong Tian Molecular Mechanisms and Function Prediction of Long Noncoding RNA The Scientific World Journal |
| title | Molecular Mechanisms and Function Prediction of Long Noncoding RNA |
| title_full | Molecular Mechanisms and Function Prediction of Long Noncoding RNA |
| title_fullStr | Molecular Mechanisms and Function Prediction of Long Noncoding RNA |
| title_full_unstemmed | Molecular Mechanisms and Function Prediction of Long Noncoding RNA |
| title_short | Molecular Mechanisms and Function Prediction of Long Noncoding RNA |
| title_sort | molecular mechanisms and function prediction of long noncoding rna |
| url | http://dx.doi.org/10.1100/2012/541786 |
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