Neuropsychological, neuroimage and psychiatric aspects of primary Sjögren's syndrome
We report a case of a 49-year-old woman diagnosed with primary Sjögrens Syndrome (pSS) who was submitted to extensive neuropsychobiological assessment. Examination revealed a Wechsler Adult Intelligence Scale-Revised (WAIS-R) Full Scale IQ of 97 with no Verbal/Performance IQ discrepancy and performa...
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| Language: | English |
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Thieme Revinter Publicações
2002-03-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2002000100006&tlng=en |
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| author | Gilberto N.O. Brito Gloria R.B. Araujo J. Angelo Papi |
| author_facet | Gilberto N.O. Brito Gloria R.B. Araujo J. Angelo Papi |
| author_sort | Gilberto N.O. Brito |
| collection | DOAJ |
| description | We report a case of a 49-year-old woman diagnosed with primary Sjögrens Syndrome (pSS) who was submitted to extensive neuropsychobiological assessment. Examination revealed a Wechsler Adult Intelligence Scale-Revised (WAIS-R) Full Scale IQ of 97 with no Verbal/Performance IQ discrepancy and performance below estimated premorbid levels on arithmetic skills, visual tracking, naming and delayed paired associate learning/memory. CT scans of the brain were normal. However, there were subcortical hyperintensities on MRI and left parieto-temporal hypoperfusion on SPECT. Neuropsychological impairment is consistent with the pattern of neuroimage findings. We hypothesize that the pathophysiological mechanisms of pSS involve direct immune attack on neurons in addition to indirect effects through small-vessel angiopathy and thereby induce natural fracture lines in behavior according to location in the central nervous system. |
| format | Article |
| id | doaj-art-95178ac3a8f44c81939f522bc0c90c52 |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 2002-03-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-95178ac3a8f44c81939f522bc0c90c522025-08-20T02:09:58ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272002-03-01601283110.1590/S0004-282X2002000100006Neuropsychological, neuroimage and psychiatric aspects of primary Sjögren's syndromeGilberto N.O. Brito0Gloria R.B. Araujo1J. Angelo Papi2Fundação Oswaldo CruzUniversidade Federal do Rio de JaneiroUniversidade Federal do Rio de JaneiroWe report a case of a 49-year-old woman diagnosed with primary Sjögrens Syndrome (pSS) who was submitted to extensive neuropsychobiological assessment. Examination revealed a Wechsler Adult Intelligence Scale-Revised (WAIS-R) Full Scale IQ of 97 with no Verbal/Performance IQ discrepancy and performance below estimated premorbid levels on arithmetic skills, visual tracking, naming and delayed paired associate learning/memory. CT scans of the brain were normal. However, there were subcortical hyperintensities on MRI and left parieto-temporal hypoperfusion on SPECT. Neuropsychological impairment is consistent with the pattern of neuroimage findings. We hypothesize that the pathophysiological mechanisms of pSS involve direct immune attack on neurons in addition to indirect effects through small-vessel angiopathy and thereby induce natural fracture lines in behavior according to location in the central nervous system.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2002000100006&tlng=enSjögren's syndromeneuropsychologyneuropsychoimmunologyneuroimagepsychiatryneuropsychobiology |
| spellingShingle | Gilberto N.O. Brito Gloria R.B. Araujo J. Angelo Papi Neuropsychological, neuroimage and psychiatric aspects of primary Sjögren's syndrome Arquivos de Neuro-Psiquiatria Sjögren's syndrome neuropsychology neuropsychoimmunology neuroimage psychiatry neuropsychobiology |
| title | Neuropsychological, neuroimage and psychiatric aspects of primary Sjögren's syndrome |
| title_full | Neuropsychological, neuroimage and psychiatric aspects of primary Sjögren's syndrome |
| title_fullStr | Neuropsychological, neuroimage and psychiatric aspects of primary Sjögren's syndrome |
| title_full_unstemmed | Neuropsychological, neuroimage and psychiatric aspects of primary Sjögren's syndrome |
| title_short | Neuropsychological, neuroimage and psychiatric aspects of primary Sjögren's syndrome |
| title_sort | neuropsychological neuroimage and psychiatric aspects of primary sjogren s syndrome |
| topic | Sjögren's syndrome neuropsychology neuropsychoimmunology neuroimage psychiatry neuropsychobiology |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2002000100006&tlng=en |
| work_keys_str_mv | AT gilbertonobrito neuropsychologicalneuroimageandpsychiatricaspectsofprimarysjogrenssyndrome AT gloriarbaraujo neuropsychologicalneuroimageandpsychiatricaspectsofprimarysjogrenssyndrome AT jangelopapi neuropsychologicalneuroimageandpsychiatricaspectsofprimarysjogrenssyndrome |