CDK4/6 inhibitors in breast cancer therapy: mechanisms of drug resistance and strategies for treatment

CDK4/6 inhibitors in breast cancer therapy: mechanisms of drug resistance and strategies for treatment

Dysregulated cell cycle progression is a well-established hallmark of cancer, driving the development of targeted antitumor therapies that intervene at specific phases of the cell cycle. Among these therapeutic targets, cyclin-dependent kinases 4 and 6 (CDK4/6) have emerged as critical regulators of...

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Bibliographic Details
Main Authors: Tong Gao, Ying Sun, Ping Leng, Donghua Liu, Qie Guo, Jing Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
CDK4/6 inhibitors
cell cycle arrest
immune regulation
acquired resistance
combination therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1549520/full
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