Engineering extracellular vesicles for ROS scavenging and tissue regeneration
Abstract Stem cell therapy holds promise for tissue regeneration, yet significant challenges persist. Emerging as a safer and potentially more effective alternative, extracellular vesicles (EVs) derived from stem cells exhibit remarkable abilities to activate critical signaling cascades, thereby fac...
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Format: | Article |
Language: | English |
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SpringerOpen
2024-06-01
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Series: | Nano Convergence |
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Online Access: | https://doi.org/10.1186/s40580-024-00430-9 |
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author | Ahmed Abdal Dayem Ellie Yan Minjae Do Yoojung Kim Yeongseo Lee Ssang-Goo Cho Deok-Ho Kim |
author_facet | Ahmed Abdal Dayem Ellie Yan Minjae Do Yoojung Kim Yeongseo Lee Ssang-Goo Cho Deok-Ho Kim |
author_sort | Ahmed Abdal Dayem |
collection | DOAJ |
description | Abstract Stem cell therapy holds promise for tissue regeneration, yet significant challenges persist. Emerging as a safer and potentially more effective alternative, extracellular vesicles (EVs) derived from stem cells exhibit remarkable abilities to activate critical signaling cascades, thereby facilitating tissue repair. EVs, nano-scale membrane vesicles, mediate intercellular communication by encapsulating a diverse cargo of proteins, lipids, and nucleic acids. Their therapeutic potential lies in delivering cargos, activating signaling pathways, and efficiently mitigating oxidative stress—an essential aspect of overcoming limitations in stem cell-based tissue repair. This review focuses on engineering and applying EVs in tissue regeneration, emphasizing their role in regulating reactive oxygen species (ROS) pathways. Additionally, we explore strategies to enhance EV therapeutic activity, including functionalization and incorporation of antioxidant defense proteins. Understanding these molecular mechanisms is crucial for optimizing EV-based regenerative therapies. Insights into EV and ROS signaling modulation pave the way for targeted and efficient regenerative therapies harnessing the potential of EVs. |
format | Article |
id | doaj-art-950a2aa28ebe4d3f8f26703548bcb61d |
institution | Kabale University |
issn | 2196-5404 |
language | English |
publishDate | 2024-06-01 |
publisher | SpringerOpen |
record_format | Article |
series | Nano Convergence |
spelling | doaj-art-950a2aa28ebe4d3f8f26703548bcb61d2025-02-02T12:36:37ZengSpringerOpenNano Convergence2196-54042024-06-0111112710.1186/s40580-024-00430-9Engineering extracellular vesicles for ROS scavenging and tissue regenerationAhmed Abdal Dayem0Ellie Yan1Minjae Do2Yoojung Kim3Yeongseo Lee4Ssang-Goo Cho5Deok-Ho Kim6Department of Stem Cell and Regenerative Biotechnology, Molecular & Cellular Reprogramming Center, Institute of Advanced Regenerative Science, Konkuk UniversityDepartment of Biomedical Engineering, Johns Hopkins UniversityDepartment of Biomedical Engineering, Johns Hopkins UniversityDepartment of Stem Cell and Regenerative Biotechnology, Molecular & Cellular Reprogramming Center, Institute of Advanced Regenerative Science, Konkuk UniversityDepartment of Stem Cell and Regenerative Biotechnology, Molecular & Cellular Reprogramming Center, Institute of Advanced Regenerative Science, Konkuk UniversityDepartment of Stem Cell and Regenerative Biotechnology, Molecular & Cellular Reprogramming Center, Institute of Advanced Regenerative Science, Konkuk UniversityDepartment of Biomedical Engineering, Johns Hopkins UniversityAbstract Stem cell therapy holds promise for tissue regeneration, yet significant challenges persist. Emerging as a safer and potentially more effective alternative, extracellular vesicles (EVs) derived from stem cells exhibit remarkable abilities to activate critical signaling cascades, thereby facilitating tissue repair. EVs, nano-scale membrane vesicles, mediate intercellular communication by encapsulating a diverse cargo of proteins, lipids, and nucleic acids. Their therapeutic potential lies in delivering cargos, activating signaling pathways, and efficiently mitigating oxidative stress—an essential aspect of overcoming limitations in stem cell-based tissue repair. This review focuses on engineering and applying EVs in tissue regeneration, emphasizing their role in regulating reactive oxygen species (ROS) pathways. Additionally, we explore strategies to enhance EV therapeutic activity, including functionalization and incorporation of antioxidant defense proteins. Understanding these molecular mechanisms is crucial for optimizing EV-based regenerative therapies. Insights into EV and ROS signaling modulation pave the way for targeted and efficient regenerative therapies harnessing the potential of EVs.https://doi.org/10.1186/s40580-024-00430-9Extracellular vesiclesTissue regenerationReactive oxygen species scavengingmiRNA deliveryBiomaterial scaffold |
spellingShingle | Ahmed Abdal Dayem Ellie Yan Minjae Do Yoojung Kim Yeongseo Lee Ssang-Goo Cho Deok-Ho Kim Engineering extracellular vesicles for ROS scavenging and tissue regeneration Nano Convergence Extracellular vesicles Tissue regeneration Reactive oxygen species scavenging miRNA delivery Biomaterial scaffold |
title | Engineering extracellular vesicles for ROS scavenging and tissue regeneration |
title_full | Engineering extracellular vesicles for ROS scavenging and tissue regeneration |
title_fullStr | Engineering extracellular vesicles for ROS scavenging and tissue regeneration |
title_full_unstemmed | Engineering extracellular vesicles for ROS scavenging and tissue regeneration |
title_short | Engineering extracellular vesicles for ROS scavenging and tissue regeneration |
title_sort | engineering extracellular vesicles for ros scavenging and tissue regeneration |
topic | Extracellular vesicles Tissue regeneration Reactive oxygen species scavenging miRNA delivery Biomaterial scaffold |
url | https://doi.org/10.1186/s40580-024-00430-9 |
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