Engineering extracellular vesicles for ROS scavenging and tissue regeneration

Abstract Stem cell therapy holds promise for tissue regeneration, yet significant challenges persist. Emerging as a safer and potentially more effective alternative, extracellular vesicles (EVs) derived from stem cells exhibit remarkable abilities to activate critical signaling cascades, thereby fac...

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Main Authors: Ahmed Abdal Dayem, Ellie Yan, Minjae Do, Yoojung Kim, Yeongseo Lee, Ssang-Goo Cho, Deok-Ho Kim
Format: Article
Language:English
Published: SpringerOpen 2024-06-01
Series:Nano Convergence
Subjects:
Online Access:https://doi.org/10.1186/s40580-024-00430-9
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author Ahmed Abdal Dayem
Ellie Yan
Minjae Do
Yoojung Kim
Yeongseo Lee
Ssang-Goo Cho
Deok-Ho Kim
author_facet Ahmed Abdal Dayem
Ellie Yan
Minjae Do
Yoojung Kim
Yeongseo Lee
Ssang-Goo Cho
Deok-Ho Kim
author_sort Ahmed Abdal Dayem
collection DOAJ
description Abstract Stem cell therapy holds promise for tissue regeneration, yet significant challenges persist. Emerging as a safer and potentially more effective alternative, extracellular vesicles (EVs) derived from stem cells exhibit remarkable abilities to activate critical signaling cascades, thereby facilitating tissue repair. EVs, nano-scale membrane vesicles, mediate intercellular communication by encapsulating a diverse cargo of proteins, lipids, and nucleic acids. Their therapeutic potential lies in delivering cargos, activating signaling pathways, and efficiently mitigating oxidative stress—an essential aspect of overcoming limitations in stem cell-based tissue repair. This review focuses on engineering and applying EVs in tissue regeneration, emphasizing their role in regulating reactive oxygen species (ROS) pathways. Additionally, we explore strategies to enhance EV therapeutic activity, including functionalization and incorporation of antioxidant defense proteins. Understanding these molecular mechanisms is crucial for optimizing EV-based regenerative therapies. Insights into EV and ROS signaling modulation pave the way for targeted and efficient regenerative therapies harnessing the potential of EVs.
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series Nano Convergence
spelling doaj-art-950a2aa28ebe4d3f8f26703548bcb61d2025-02-02T12:36:37ZengSpringerOpenNano Convergence2196-54042024-06-0111112710.1186/s40580-024-00430-9Engineering extracellular vesicles for ROS scavenging and tissue regenerationAhmed Abdal Dayem0Ellie Yan1Minjae Do2Yoojung Kim3Yeongseo Lee4Ssang-Goo Cho5Deok-Ho Kim6Department of Stem Cell and Regenerative Biotechnology, Molecular & Cellular Reprogramming Center, Institute of Advanced Regenerative Science, Konkuk UniversityDepartment of Biomedical Engineering, Johns Hopkins UniversityDepartment of Biomedical Engineering, Johns Hopkins UniversityDepartment of Stem Cell and Regenerative Biotechnology, Molecular & Cellular Reprogramming Center, Institute of Advanced Regenerative Science, Konkuk UniversityDepartment of Stem Cell and Regenerative Biotechnology, Molecular & Cellular Reprogramming Center, Institute of Advanced Regenerative Science, Konkuk UniversityDepartment of Stem Cell and Regenerative Biotechnology, Molecular & Cellular Reprogramming Center, Institute of Advanced Regenerative Science, Konkuk UniversityDepartment of Biomedical Engineering, Johns Hopkins UniversityAbstract Stem cell therapy holds promise for tissue regeneration, yet significant challenges persist. Emerging as a safer and potentially more effective alternative, extracellular vesicles (EVs) derived from stem cells exhibit remarkable abilities to activate critical signaling cascades, thereby facilitating tissue repair. EVs, nano-scale membrane vesicles, mediate intercellular communication by encapsulating a diverse cargo of proteins, lipids, and nucleic acids. Their therapeutic potential lies in delivering cargos, activating signaling pathways, and efficiently mitigating oxidative stress—an essential aspect of overcoming limitations in stem cell-based tissue repair. This review focuses on engineering and applying EVs in tissue regeneration, emphasizing their role in regulating reactive oxygen species (ROS) pathways. Additionally, we explore strategies to enhance EV therapeutic activity, including functionalization and incorporation of antioxidant defense proteins. Understanding these molecular mechanisms is crucial for optimizing EV-based regenerative therapies. Insights into EV and ROS signaling modulation pave the way for targeted and efficient regenerative therapies harnessing the potential of EVs.https://doi.org/10.1186/s40580-024-00430-9Extracellular vesiclesTissue regenerationReactive oxygen species scavengingmiRNA deliveryBiomaterial scaffold
spellingShingle Ahmed Abdal Dayem
Ellie Yan
Minjae Do
Yoojung Kim
Yeongseo Lee
Ssang-Goo Cho
Deok-Ho Kim
Engineering extracellular vesicles for ROS scavenging and tissue regeneration
Nano Convergence
Extracellular vesicles
Tissue regeneration
Reactive oxygen species scavenging
miRNA delivery
Biomaterial scaffold
title Engineering extracellular vesicles for ROS scavenging and tissue regeneration
title_full Engineering extracellular vesicles for ROS scavenging and tissue regeneration
title_fullStr Engineering extracellular vesicles for ROS scavenging and tissue regeneration
title_full_unstemmed Engineering extracellular vesicles for ROS scavenging and tissue regeneration
title_short Engineering extracellular vesicles for ROS scavenging and tissue regeneration
title_sort engineering extracellular vesicles for ros scavenging and tissue regeneration
topic Extracellular vesicles
Tissue regeneration
Reactive oxygen species scavenging
miRNA delivery
Biomaterial scaffold
url https://doi.org/10.1186/s40580-024-00430-9
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