Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation

Abstract Microglia activation is the brain's major immune response to amyloid plaques in Alzheimer's disease (AD). Both cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2), a biomarker of microglia activation, and microglia PET are increased in AD; however, whether an increase in th...

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Main Authors: Michael Ewers, Gloria Biechele, Marc Suárez‐Calvet, Christian Sacher, Tanja Blume, Estrella Morenas‐Rodriguez, Yuetiva Deming, Laura Piccio, Carlos Cruchaga, Gernot Kleinberger, Leslie Shaw, John Q Trojanowski, Jochen Herms, Martin Dichgans, the Alzheimer's Disease Neuroimaging Initiative (ADNI), Matthias Brendel, Christian Haass, Nicolai Franzmeier
Format: Article
Language:English
Published: Springer Nature 2020-08-01
Series:EMBO Molecular Medicine
Subjects:
beta‐amyloid accumulation
microglia
protective
tau
TREM2
Online Access:https://doi.org/10.15252/emmm.202012308
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