Mortality and Risk Factors for Emphysematous Pyelonephritis in Korea: A Multicenter Retrospective Cohort Study
Purpose Emphysematous pyelonephritis (EPN) is a life-threatening disease requiring immediate treatment. This multicenter retrospective cohort study aimed to analyze the mortality rate and risk factors associated with EPN. Materials and Methods Between January 2011 and February 2021, 217 patients dia...
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Korean Association of Urogenital Tract Infection and Inflammation
2025-04-01
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| Series: | Urogenital Tract Infection |
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| Online Access: | http://euti.org/upload/pdf/uti-2550006003.pdf |
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| author | Seung-Kwon Choi Jeong Woo Lee Seung Il Jung Eu Chang Hwang Joongwon Choi Woong Bin Kim Jung Sik Huh Jin Bong Choi Yeonjoo Kim Jae Min Chung Ju-Hyun Shin Jae Hung Jung Hong Chung Sangrak Bae Tae-Hyoung Kim |
| author_facet | Seung-Kwon Choi Jeong Woo Lee Seung Il Jung Eu Chang Hwang Joongwon Choi Woong Bin Kim Jung Sik Huh Jin Bong Choi Yeonjoo Kim Jae Min Chung Ju-Hyun Shin Jae Hung Jung Hong Chung Sangrak Bae Tae-Hyoung Kim |
| author_sort | Seung-Kwon Choi |
| collection | DOAJ |
| description | Purpose Emphysematous pyelonephritis (EPN) is a life-threatening disease requiring immediate treatment. This multicenter retrospective cohort study aimed to analyze the mortality rate and risk factors associated with EPN. Materials and Methods Between January 2011 and February 2021, 217 patients diagnosed with EPN via computed tomography who visited 14 teaching hospitals were retrospectively analyzed. Clinical data, including age, sex, comorbidities, Huang and Tseng classification, hydronephrosis, acute kidney injury, blood and urine tests, surgical interventions, percutaneous drainage, and conservative treatments, were compared between the survival and death groups. Risk factors for mortality due to EPN were analyzed using univariate and multivariate methods. Results The mean age of survivors and deceased patients was 67.8 and 69.0 years, respectively (p=0.136). The sex distribution (male/female) was 48/146 and 8/15, respectively (p=0.298). Of the 217 patients, 23 died, resulting in a mortality rate of 10.6%. In univariate analysis, the Huang and Tseng classification (p=0.004), platelet count (p=0.005), and acute kidney injury (p=0.007) were significantly associated with mortality from EPN. In multivariate analysis, only the Huang and Tseng classification (p=0.029) was identified as a risk factor. Mortality rates according to the Huang and Tseng classification were as follows: class I (5.88%), class II (7.50%), class IIIa (14.28%), class IIIb (25.00%), and class IV (23.07%). Conclusions EPN is associated with a high mortality rate. Among various clinical factors, the Huang and Tseng classification was the most significant indicator for predicting mortality. |
| format | Article |
| id | doaj-art-94fe8b409efc4c0885aab96df4d197ee |
| institution | Kabale University |
| issn | 2465-8243 2465-8510 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Korean Association of Urogenital Tract Infection and Inflammation |
| record_format | Article |
| series | Urogenital Tract Infection |
| spelling | doaj-art-94fe8b409efc4c0885aab96df4d197ee2025-08-20T03:58:11ZengKorean Association of Urogenital Tract Infection and InflammationUrogenital Tract Infection2465-82432465-85102025-04-01201344110.14777/uti.2550006003433Mortality and Risk Factors for Emphysematous Pyelonephritis in Korea: A Multicenter Retrospective Cohort StudySeung-Kwon Choi0Jeong Woo Lee1Seung Il Jung2Eu Chang Hwang3Joongwon Choi4Woong Bin Kim5Jung Sik Huh6Jin Bong Choi7Yeonjoo Kim8Jae Min Chung9Ju-Hyun Shin10Jae Hung Jung11Hong Chung12Sangrak Bae13Tae-Hyoung Kim14 Department of Urology, Seoul Medical Center, Seoul, Korea Department of Urology, Kyung Hee University College of Medicine, Seoul, Korea Department of Urology, Chonnam National University Medical School, Gwangju, Korea Department of Urology, Chonnam National University Medical School, Gwangju, Korea Department of Urology, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong, Korea Department of Urology, Soonchunhyang University College of Medicine, Cheonan, Korea Department of Urology, Jeju National University College of Medicine, Jeju, Korea Department of Urology, The Catholic University of Korea College of Medicine, Seoul, Korea Department of Urology, Daegu Fatima Hospital, Daegu, Korea Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea Department of Urology, Chungnam National University College of Medicine, Daejeon, Korea Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea Department of Urology, Uijeongbu St. Mary’ Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea Department of Urology, Chung-Ang University College of Medicine, Seoul, KoreaPurpose Emphysematous pyelonephritis (EPN) is a life-threatening disease requiring immediate treatment. This multicenter retrospective cohort study aimed to analyze the mortality rate and risk factors associated with EPN. Materials and Methods Between January 2011 and February 2021, 217 patients diagnosed with EPN via computed tomography who visited 14 teaching hospitals were retrospectively analyzed. Clinical data, including age, sex, comorbidities, Huang and Tseng classification, hydronephrosis, acute kidney injury, blood and urine tests, surgical interventions, percutaneous drainage, and conservative treatments, were compared between the survival and death groups. Risk factors for mortality due to EPN were analyzed using univariate and multivariate methods. Results The mean age of survivors and deceased patients was 67.8 and 69.0 years, respectively (p=0.136). The sex distribution (male/female) was 48/146 and 8/15, respectively (p=0.298). Of the 217 patients, 23 died, resulting in a mortality rate of 10.6%. In univariate analysis, the Huang and Tseng classification (p=0.004), platelet count (p=0.005), and acute kidney injury (p=0.007) were significantly associated with mortality from EPN. In multivariate analysis, only the Huang and Tseng classification (p=0.029) was identified as a risk factor. Mortality rates according to the Huang and Tseng classification were as follows: class I (5.88%), class II (7.50%), class IIIa (14.28%), class IIIb (25.00%), and class IV (23.07%). Conclusions EPN is associated with a high mortality rate. Among various clinical factors, the Huang and Tseng classification was the most significant indicator for predicting mortality.http://euti.org/upload/pdf/uti-2550006003.pdfpyelonephritisemphysemaincidencetreatment outcomemortality |
| spellingShingle | Seung-Kwon Choi Jeong Woo Lee Seung Il Jung Eu Chang Hwang Joongwon Choi Woong Bin Kim Jung Sik Huh Jin Bong Choi Yeonjoo Kim Jae Min Chung Ju-Hyun Shin Jae Hung Jung Hong Chung Sangrak Bae Tae-Hyoung Kim Mortality and Risk Factors for Emphysematous Pyelonephritis in Korea: A Multicenter Retrospective Cohort Study Urogenital Tract Infection pyelonephritis emphysema incidence treatment outcome mortality |
| title | Mortality and Risk Factors for Emphysematous Pyelonephritis in Korea: A Multicenter Retrospective Cohort Study |
| title_full | Mortality and Risk Factors for Emphysematous Pyelonephritis in Korea: A Multicenter Retrospective Cohort Study |
| title_fullStr | Mortality and Risk Factors for Emphysematous Pyelonephritis in Korea: A Multicenter Retrospective Cohort Study |
| title_full_unstemmed | Mortality and Risk Factors for Emphysematous Pyelonephritis in Korea: A Multicenter Retrospective Cohort Study |
| title_short | Mortality and Risk Factors for Emphysematous Pyelonephritis in Korea: A Multicenter Retrospective Cohort Study |
| title_sort | mortality and risk factors for emphysematous pyelonephritis in korea a multicenter retrospective cohort study |
| topic | pyelonephritis emphysema incidence treatment outcome mortality |
| url | http://euti.org/upload/pdf/uti-2550006003.pdf |
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