Single-cell RNA-seq uncovers lineage-specific regulatory alterations of fibroblasts and endothelial cells in ligamentum flavum hypertrophy

Single-cell RNA-seq uncovers lineage-specific regulatory alterations of fibroblasts and endothelial cells in ligamentum flavum hypertrophy

BackgroundLumbar spinal stenosis (LSS) represents a major global healthcare burden resulting in back pain and disorders of the limbs among the elderly population. The hypertrophy of ligamentum flavum (HLF), marked by fibrosis and inflammation, significantly contributes to LSS. Fibroblasts and endoth...

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Bibliographic Details
Main Authors: Yongxin Chen, Jue Zhang, Xincheng Feng, Qinghong Ma, Chao Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
lumbar spinal stenosis
hypertrophy
scRNA-seq
fibroblast
endothelial cell
ligamentum flavum
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1569296/full
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