Analysis of Therapeutic Options for Noise-Induced Hearing Loss: Retroauricular Injection of Methylprednisolone Sodium Succinate Combined with Hyperbaric Oxygenation
Objective: To evaluate the clinical effect of retroaural injection of methylprednisolone sodium succinate combined with hyperbaric oxygen (HBO) on the treatment of noise-induced hearing loss. Methods: Case data of 220 patients with hearing loss treated at the Zhongda Hospital Southeast University fr...
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Wolters Kluwer Medknow Publications
2024-09-01
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| Series: | Noise and Health |
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| Online Access: | https://journals.lww.com/10.4103/nah.nah_60_24 |
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| author | Yan Yao Lei Li |
| author_facet | Yan Yao Lei Li |
| author_sort | Yan Yao |
| collection | DOAJ |
| description | Objective: To evaluate the clinical effect of retroaural injection of methylprednisolone sodium succinate combined with hyperbaric oxygen (HBO) on the treatment of noise-induced hearing loss. Methods: Case data of 220 patients with hearing loss treated at the Zhongda Hospital Southeast University from January 1, 2019 to August 1, 2023 were obtained. As per the treatment plan, the recruited patients were divided into two cohorts: 158 cases in the combined-treatment group (retroaural injection of methylprednisolone sodium succinate combined with HBO) and 62 cases in the single-hormone group (retroaural injection of methylprednisolone sodium succinate). Comparison of the clinical efficacies and postoperative complication rates of the two groups was performed after treatment. MS-Excel was used to build a database for all data, and SPSS26.0 was utilized in the statistical analysis of recorded data. Results: For patients with low-frequency, high-frequency, and flat descending type, the combined-treatment group showed significantly higher clinical effective rate than the single-hormone group (P < 0.05). For patients with disease duration ≤7 days, the combined-treatment group attained a significantly higher clinical effective rate was than the single-hormone group (P < 0.05). The safety of patients in both groups was evaluated mainly through their adverse reactions. The total incidence of adverse reactions in the single-hormone group reached 9.68%, and that in the combined-treatment group was 8.23%. The two groups revealed no significant difference in terms of incidence of adverse reactions (P > 0.05). Conclusion: HBO combined with retroaural injection of methylprednisolone sodium succinate has good clinical efficacy and safety in the treatment of hearing loss. |
| format | Article |
| id | doaj-art-94f4346dc67f42b49e592a124e3f42a2 |
| institution | OA Journals |
| issn | 1463-1741 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Wolters Kluwer Medknow Publications |
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| series | Noise and Health |
| spelling | doaj-art-94f4346dc67f42b49e592a124e3f42a22025-08-20T02:13:51ZengWolters Kluwer Medknow PublicationsNoise and Health1463-17412024-09-012612237037510.4103/nah.nah_60_24Analysis of Therapeutic Options for Noise-Induced Hearing Loss: Retroauricular Injection of Methylprednisolone Sodium Succinate Combined with Hyperbaric OxygenationYan YaoLei LiObjective: To evaluate the clinical effect of retroaural injection of methylprednisolone sodium succinate combined with hyperbaric oxygen (HBO) on the treatment of noise-induced hearing loss. Methods: Case data of 220 patients with hearing loss treated at the Zhongda Hospital Southeast University from January 1, 2019 to August 1, 2023 were obtained. As per the treatment plan, the recruited patients were divided into two cohorts: 158 cases in the combined-treatment group (retroaural injection of methylprednisolone sodium succinate combined with HBO) and 62 cases in the single-hormone group (retroaural injection of methylprednisolone sodium succinate). Comparison of the clinical efficacies and postoperative complication rates of the two groups was performed after treatment. MS-Excel was used to build a database for all data, and SPSS26.0 was utilized in the statistical analysis of recorded data. Results: For patients with low-frequency, high-frequency, and flat descending type, the combined-treatment group showed significantly higher clinical effective rate than the single-hormone group (P < 0.05). For patients with disease duration ≤7 days, the combined-treatment group attained a significantly higher clinical effective rate was than the single-hormone group (P < 0.05). The safety of patients in both groups was evaluated mainly through their adverse reactions. The total incidence of adverse reactions in the single-hormone group reached 9.68%, and that in the combined-treatment group was 8.23%. The two groups revealed no significant difference in terms of incidence of adverse reactions (P > 0.05). Conclusion: HBO combined with retroaural injection of methylprednisolone sodium succinate has good clinical efficacy and safety in the treatment of hearing loss.https://journals.lww.com/10.4103/nah.nah_60_24methylprednisolone hemisuccinatehyperbaric oxygenationnoisehearing loss |
| spellingShingle | Yan Yao Lei Li Analysis of Therapeutic Options for Noise-Induced Hearing Loss: Retroauricular Injection of Methylprednisolone Sodium Succinate Combined with Hyperbaric Oxygenation Noise and Health methylprednisolone hemisuccinate hyperbaric oxygenation noise hearing loss |
| title | Analysis of Therapeutic Options for Noise-Induced Hearing Loss: Retroauricular Injection of Methylprednisolone Sodium Succinate Combined with Hyperbaric Oxygenation |
| title_full | Analysis of Therapeutic Options for Noise-Induced Hearing Loss: Retroauricular Injection of Methylprednisolone Sodium Succinate Combined with Hyperbaric Oxygenation |
| title_fullStr | Analysis of Therapeutic Options for Noise-Induced Hearing Loss: Retroauricular Injection of Methylprednisolone Sodium Succinate Combined with Hyperbaric Oxygenation |
| title_full_unstemmed | Analysis of Therapeutic Options for Noise-Induced Hearing Loss: Retroauricular Injection of Methylprednisolone Sodium Succinate Combined with Hyperbaric Oxygenation |
| title_short | Analysis of Therapeutic Options for Noise-Induced Hearing Loss: Retroauricular Injection of Methylprednisolone Sodium Succinate Combined with Hyperbaric Oxygenation |
| title_sort | analysis of therapeutic options for noise induced hearing loss retroauricular injection of methylprednisolone sodium succinate combined with hyperbaric oxygenation |
| topic | methylprednisolone hemisuccinate hyperbaric oxygenation noise hearing loss |
| url | https://journals.lww.com/10.4103/nah.nah_60_24 |
| work_keys_str_mv | AT yanyao analysisoftherapeuticoptionsfornoiseinducedhearinglossretroauricularinjectionofmethylprednisolonesodiumsuccinatecombinedwithhyperbaricoxygenation AT leili analysisoftherapeuticoptionsfornoiseinducedhearinglossretroauricularinjectionofmethylprednisolonesodiumsuccinatecombinedwithhyperbaricoxygenation |