METTL3-VISTA axis-based combination immunotherapy for APC truncation colorectal cancer

METTL3-VISTA axis-based combination immunotherapy for APC truncation colorectal cancer

Objective Although immune checkpoint blockade (ICB) therapy represents a bright spot in antitumor immunotherapy, its clinical benefits in colorectal cancer (CRC) are limited. Therefore, a new target for mediating CRC immunosuppression is urgently needed. Adenomatous polyposis coli (APC) mutations ha...

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Bibliographic Details
Main Authors: Hui Wang, Yujie Zhang, Ling Wu, Liang Zhao, Hao Chen, Rui Bai, Jianghua Wu, Zetao Chen
Format: Article
Language:English
Published: BMJ Publishing Group 2024-12-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/12/e009865.full
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