A Quantitative Trait Locus on Chromosome 5p Influences D-Dimer Levels in the San Antonio Family Heart Study
Background. D-dimer is associated with increasing severity of atherosclerosis and with increased risk of a cardiovascular disease (CVD). Methods and Results. To better understand this risk factor, we performed a genome scan on 803 (301 males and 502 females) Mexican Americans in...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2010/490241 |
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| author | V. P. Diego L. Almasy D. L. Rainwater M. C. Mahaney A. G. Comuzzie S. A. Cole R. P. Tracy M. P. Stern J. W. MacCluer J. Blangero |
| author_facet | V. P. Diego L. Almasy D. L. Rainwater M. C. Mahaney A. G. Comuzzie S. A. Cole R. P. Tracy M. P. Stern J. W. MacCluer J. Blangero |
| author_sort | V. P. Diego |
| collection | DOAJ |
| description | Background. D-dimer is associated with increasing severity of atherosclerosis and with increased risk of a cardiovascular disease (CVD).
Methods and Results. To better understand this risk factor, we performed a genome scan on 803 (301 males and 502 females) Mexican Americans in the San Antonio Family Heart Study (SAFHS). The SAFHS is ideal for the discovery of quantitative trait loci (QTLs) influencing CVD because CVD risk factors are prevalent in Mexican Americans of San Antonio and because the study design involves large families, which is optimal for QTL discovery.
D-dimer levels were normalized in our study. We found that D-dimer levels were heritable, at about 23% heritability (P≈.00001). In a linkage analysis employing 432 microsatellite markers, we found strong evidence of a QTL on chromosome 5p with a lod score of 3.32 at 21 centiMorgans (cM). We also found suggestive evidence of a QTL on chromosome 2q with a lod score of 2.33 at 207 cM.
Conclusions. To our knowledge, the putative QTL on chromosome 5p is novel. The possible QTL on chromosome 2q is discussed in relation to a recent report of linkage of a related hemostatic factor to the same location. These results warrant further investigation. |
| format | Article |
| id | doaj-art-94e690e510c8400a869e310a4e4e5a1f |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-94e690e510c8400a869e310a4e4e5a1f2025-02-03T01:26:50ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322010-01-01201010.1155/2010/490241490241A Quantitative Trait Locus on Chromosome 5p Influences D-Dimer Levels in the San Antonio Family Heart StudyV. P. Diego0L. Almasy1D. L. Rainwater2M. C. Mahaney3A. G. Comuzzie4S. A. Cole5R. P. Tracy6M. P. Stern7J. W. MacCluer8J. Blangero9Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USADepartment of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USADepartment of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USADepartment of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USADepartment of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USADepartment of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USADepartment of Pathology, University of Vermont, Colchester, VT 05446, USADepartment of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USADepartment of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USADepartment of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USABackground. D-dimer is associated with increasing severity of atherosclerosis and with increased risk of a cardiovascular disease (CVD). Methods and Results. To better understand this risk factor, we performed a genome scan on 803 (301 males and 502 females) Mexican Americans in the San Antonio Family Heart Study (SAFHS). The SAFHS is ideal for the discovery of quantitative trait loci (QTLs) influencing CVD because CVD risk factors are prevalent in Mexican Americans of San Antonio and because the study design involves large families, which is optimal for QTL discovery. D-dimer levels were normalized in our study. We found that D-dimer levels were heritable, at about 23% heritability (P≈.00001). In a linkage analysis employing 432 microsatellite markers, we found strong evidence of a QTL on chromosome 5p with a lod score of 3.32 at 21 centiMorgans (cM). We also found suggestive evidence of a QTL on chromosome 2q with a lod score of 2.33 at 207 cM. Conclusions. To our knowledge, the putative QTL on chromosome 5p is novel. The possible QTL on chromosome 2q is discussed in relation to a recent report of linkage of a related hemostatic factor to the same location. These results warrant further investigation.http://dx.doi.org/10.1155/2010/490241 |
| spellingShingle | V. P. Diego L. Almasy D. L. Rainwater M. C. Mahaney A. G. Comuzzie S. A. Cole R. P. Tracy M. P. Stern J. W. MacCluer J. Blangero A Quantitative Trait Locus on Chromosome 5p Influences D-Dimer Levels in the San Antonio Family Heart Study International Journal of Vascular Medicine |
| title | A Quantitative Trait Locus on Chromosome 5p Influences D-Dimer Levels in the San Antonio Family Heart Study |
| title_full | A Quantitative Trait Locus on Chromosome 5p Influences D-Dimer Levels in the San Antonio Family Heart Study |
| title_fullStr | A Quantitative Trait Locus on Chromosome 5p Influences D-Dimer Levels in the San Antonio Family Heart Study |
| title_full_unstemmed | A Quantitative Trait Locus on Chromosome 5p Influences D-Dimer Levels in the San Antonio Family Heart Study |
| title_short | A Quantitative Trait Locus on Chromosome 5p Influences D-Dimer Levels in the San Antonio Family Heart Study |
| title_sort | quantitative trait locus on chromosome 5p influences d dimer levels in the san antonio family heart study |
| url | http://dx.doi.org/10.1155/2010/490241 |
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