Comparative in silico analyses between Lactiplantibacillus plantarum and Bifidobacterium longum concerning probiotic properties, anti-lipidemic, and anti-diabetic in vitro activities
Abstract The gut microbiota plays a crucial role in gastrointestinal health, immune function, and overall well-being. Dysbiosis has been linked to various conditions such as colon cancer, atopic diseases, mental disorders, autoimmune disorders, obesity, and diabetes. This in vitro study aims to asse...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-06-01
|
| Series: | BMC Microbiology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12866-025-04062-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850223757821476864 |
|---|---|
| author | Asmaa Negm El-Dein Wafa A. Alshehri Ashjan F. Khalel Hassan M. Awad |
| author_facet | Asmaa Negm El-Dein Wafa A. Alshehri Ashjan F. Khalel Hassan M. Awad |
| author_sort | Asmaa Negm El-Dein |
| collection | DOAJ |
| description | Abstract The gut microbiota plays a crucial role in gastrointestinal health, immune function, and overall well-being. Dysbiosis has been linked to various conditions such as colon cancer, atopic diseases, mental disorders, autoimmune disorders, obesity, and diabetes. This in vitro study aims to assess the safety and functional potential of two probiotic strains, Lactiplantibacillus (L) plantarum and Bifidobacterium (B) longum, focusing on their anti-lipidemic, anti-diabetic, antioxidant, and probiotic properties. The strains were tested for stress tolerance, including acidic, alkaline, osmotic, oxidative, thermal, detergent, bile salt, and pancreatic enzyme conditions. Both strains exhibited strong resilience, often surpassing the control strain. Their antioxidant activity, measured by radical scavenging ability, was comparable to ascorbic acid, with values of 77% for L. plantarum and 92% for B. longum. Cholesterol-lowering capacity reached 50% and 49% after 3 days, increasing to 59% and 78% after 7 days, respectively. Hydrophobicity, an indicator of adhesion potential, was approximately 78% for L. plantarum and 80% for B. longum. Additionally, both strains showed low α-amylase activity (91.65 and 92.33 U/ml), suggesting a potential role in slowing carbohydrate digestion and managing blood glucose levels. Overall, the strains demonstrated favorable safety profiles and promising functional attributes for alleviating hyperlipidemia and diabetes. PCA and heatmap analyses further highlighted L. plantarum as the most promising candidate. |
| format | Article |
| id | doaj-art-94e04d99d515411bb3100257b7b02e37 |
| institution | OA Journals |
| issn | 1471-2180 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Microbiology |
| spelling | doaj-art-94e04d99d515411bb3100257b7b02e372025-08-20T02:05:49ZengBMCBMC Microbiology1471-21802025-06-0125111110.1186/s12866-025-04062-9Comparative in silico analyses between Lactiplantibacillus plantarum and Bifidobacterium longum concerning probiotic properties, anti-lipidemic, and anti-diabetic in vitro activitiesAsmaa Negm El-Dein0Wafa A. Alshehri1Ashjan F. Khalel2Hassan M. Awad3Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research CentreDepartment of Biological Sciences, College of Science, University of JeddahBiology Department, University Collage of Aldarb, Jazan UniversityChemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research CentreAbstract The gut microbiota plays a crucial role in gastrointestinal health, immune function, and overall well-being. Dysbiosis has been linked to various conditions such as colon cancer, atopic diseases, mental disorders, autoimmune disorders, obesity, and diabetes. This in vitro study aims to assess the safety and functional potential of two probiotic strains, Lactiplantibacillus (L) plantarum and Bifidobacterium (B) longum, focusing on their anti-lipidemic, anti-diabetic, antioxidant, and probiotic properties. The strains were tested for stress tolerance, including acidic, alkaline, osmotic, oxidative, thermal, detergent, bile salt, and pancreatic enzyme conditions. Both strains exhibited strong resilience, often surpassing the control strain. Their antioxidant activity, measured by radical scavenging ability, was comparable to ascorbic acid, with values of 77% for L. plantarum and 92% for B. longum. Cholesterol-lowering capacity reached 50% and 49% after 3 days, increasing to 59% and 78% after 7 days, respectively. Hydrophobicity, an indicator of adhesion potential, was approximately 78% for L. plantarum and 80% for B. longum. Additionally, both strains showed low α-amylase activity (91.65 and 92.33 U/ml), suggesting a potential role in slowing carbohydrate digestion and managing blood glucose levels. Overall, the strains demonstrated favorable safety profiles and promising functional attributes for alleviating hyperlipidemia and diabetes. PCA and heatmap analyses further highlighted L. plantarum as the most promising candidate.https://doi.org/10.1186/s12866-025-04062-9Lactiplantibacillus plantarumBifidobacterium longumGenotypic identificationProbiotic propertiesIn vitro anti-lipidemic and anti-diabetic activities |
| spellingShingle | Asmaa Negm El-Dein Wafa A. Alshehri Ashjan F. Khalel Hassan M. Awad Comparative in silico analyses between Lactiplantibacillus plantarum and Bifidobacterium longum concerning probiotic properties, anti-lipidemic, and anti-diabetic in vitro activities BMC Microbiology Lactiplantibacillus plantarum Bifidobacterium longum Genotypic identification Probiotic properties In vitro anti-lipidemic and anti-diabetic activities |
| title | Comparative in silico analyses between Lactiplantibacillus plantarum and Bifidobacterium longum concerning probiotic properties, anti-lipidemic, and anti-diabetic in vitro activities |
| title_full | Comparative in silico analyses between Lactiplantibacillus plantarum and Bifidobacterium longum concerning probiotic properties, anti-lipidemic, and anti-diabetic in vitro activities |
| title_fullStr | Comparative in silico analyses between Lactiplantibacillus plantarum and Bifidobacterium longum concerning probiotic properties, anti-lipidemic, and anti-diabetic in vitro activities |
| title_full_unstemmed | Comparative in silico analyses between Lactiplantibacillus plantarum and Bifidobacterium longum concerning probiotic properties, anti-lipidemic, and anti-diabetic in vitro activities |
| title_short | Comparative in silico analyses between Lactiplantibacillus plantarum and Bifidobacterium longum concerning probiotic properties, anti-lipidemic, and anti-diabetic in vitro activities |
| title_sort | comparative in silico analyses between lactiplantibacillus plantarum and bifidobacterium longum concerning probiotic properties anti lipidemic and anti diabetic in vitro activities |
| topic | Lactiplantibacillus plantarum Bifidobacterium longum Genotypic identification Probiotic properties In vitro anti-lipidemic and anti-diabetic activities |
| url | https://doi.org/10.1186/s12866-025-04062-9 |
| work_keys_str_mv | AT asmaanegmeldein comparativeinsilicoanalysesbetweenlactiplantibacillusplantarumandbifidobacteriumlongumconcerningprobioticpropertiesantilipidemicandantidiabeticinvitroactivities AT wafaaalshehri comparativeinsilicoanalysesbetweenlactiplantibacillusplantarumandbifidobacteriumlongumconcerningprobioticpropertiesantilipidemicandantidiabeticinvitroactivities AT ashjanfkhalel comparativeinsilicoanalysesbetweenlactiplantibacillusplantarumandbifidobacteriumlongumconcerningprobioticpropertiesantilipidemicandantidiabeticinvitroactivities AT hassanmawad comparativeinsilicoanalysesbetweenlactiplantibacillusplantarumandbifidobacteriumlongumconcerningprobioticpropertiesantilipidemicandantidiabeticinvitroactivities |