Identification of Post-Transcriptional Modulators of Breast Cancer Transcription Factor Activity Using MINDy.
We have recently identified transcription factors (TFs) that are key drivers of breast cancer risk. To better understand the pathways or sub-networks in which these TFs mediate their function we sought to identify upstream modulators of their activity. We applied the MINDy (Modulator Inference by Ne...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0168770&type=printable |
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| author | Thomas M Campbell Mauro A A Castro Bruce A J Ponder Kerstin B Meyer |
| author_facet | Thomas M Campbell Mauro A A Castro Bruce A J Ponder Kerstin B Meyer |
| author_sort | Thomas M Campbell |
| collection | DOAJ |
| description | We have recently identified transcription factors (TFs) that are key drivers of breast cancer risk. To better understand the pathways or sub-networks in which these TFs mediate their function we sought to identify upstream modulators of their activity. We applied the MINDy (Modulator Inference by Network Dynamics) algorithm to four TFs (ESR1, FOXA1, GATA3 and SPDEF) that are key drivers of estrogen receptor-positive (ER+) breast cancer risk, as well as cancer progression. Our computational analysis identified over 500 potential modulators. We assayed 189 of these and identified 55 genes with functional characteristics that were consistent with a role as TF modulators. In the future, the identified modulators may be tested as potential therapeutic targets, able to alter the activity of TFs that are critical in the development of breast cancer. |
| format | Article |
| id | doaj-art-94de4758fde2418883519ba4c5862f0f |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-94de4758fde2418883519ba4c5862f0f2025-08-20T03:26:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011112e016877010.1371/journal.pone.0168770Identification of Post-Transcriptional Modulators of Breast Cancer Transcription Factor Activity Using MINDy.Thomas M CampbellMauro A A CastroBruce A J PonderKerstin B MeyerWe have recently identified transcription factors (TFs) that are key drivers of breast cancer risk. To better understand the pathways or sub-networks in which these TFs mediate their function we sought to identify upstream modulators of their activity. We applied the MINDy (Modulator Inference by Network Dynamics) algorithm to four TFs (ESR1, FOXA1, GATA3 and SPDEF) that are key drivers of estrogen receptor-positive (ER+) breast cancer risk, as well as cancer progression. Our computational analysis identified over 500 potential modulators. We assayed 189 of these and identified 55 genes with functional characteristics that were consistent with a role as TF modulators. In the future, the identified modulators may be tested as potential therapeutic targets, able to alter the activity of TFs that are critical in the development of breast cancer.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0168770&type=printable |
| spellingShingle | Thomas M Campbell Mauro A A Castro Bruce A J Ponder Kerstin B Meyer Identification of Post-Transcriptional Modulators of Breast Cancer Transcription Factor Activity Using MINDy. PLoS ONE |
| title | Identification of Post-Transcriptional Modulators of Breast Cancer Transcription Factor Activity Using MINDy. |
| title_full | Identification of Post-Transcriptional Modulators of Breast Cancer Transcription Factor Activity Using MINDy. |
| title_fullStr | Identification of Post-Transcriptional Modulators of Breast Cancer Transcription Factor Activity Using MINDy. |
| title_full_unstemmed | Identification of Post-Transcriptional Modulators of Breast Cancer Transcription Factor Activity Using MINDy. |
| title_short | Identification of Post-Transcriptional Modulators of Breast Cancer Transcription Factor Activity Using MINDy. |
| title_sort | identification of post transcriptional modulators of breast cancer transcription factor activity using mindy |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0168770&type=printable |
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