The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions: A Pilot Experiment
Background. Fat affects gastric emptying (GE). 5-Hydroxythryptophan (5-HTP) is involved in central and peripheral satiety mechanisms. Influence of 5-HTP in addition to saturated or monounsaturated fatty acids (FA) on GE and hormone release was investigated. Subjects/Methods. 24 healthy in...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/424503 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564553906388992 |
|---|---|
| author | Helene Sauer Isabelle Mack Silke Kohler Stefanie Siegle Nicole Rieber Stephan Zipfel Bärbel Otto Yvonne Ritze Stephan C. Bischoff Paul Enck |
| author_facet | Helene Sauer Isabelle Mack Silke Kohler Stefanie Siegle Nicole Rieber Stephan Zipfel Bärbel Otto Yvonne Ritze Stephan C. Bischoff Paul Enck |
| author_sort | Helene Sauer |
| collection | DOAJ |
| description | Background.
Fat affects gastric emptying (GE). 5-Hydroxythryptophan (5-HTP) is involved in central and peripheral satiety mechanisms. Influence of 5-HTP in addition to saturated or monounsaturated fatty acids (FA) on GE and hormone release was investigated.
Subjects/Methods.
24 healthy individuals (12f : 12m, 22–29 years, BMI 19–25.7 kg/m²) were tested on 4 days with either 5-HTP + short-chain saturated FA (butter), placebo + butter, 5-HTP + monounsaturated FA (olive oil), or placebo + olive oil in double-blinded randomized order. Two hours after FA/5-HTP or placebo intake, a 13C octanoid acid test was conducted. Cortisol, serotonin, cholecystokinin (CCK), and ghrelin were measured, as were mood and GE.
Results.
GE was delayed with butter and was normal with olive (P<0.05) but not affected by 5-HTP. 5-HTP supplementation did not affect serotonin levels. Food intake increased plasma CCK (F=6.136; P<0.05) irrespective of the FA. Ghrelin levels significantly decreased with oil/5-HTP (F=9.166; P<0.001). The diurnal cortisol profile was unaffected by FA or 5-HTP, as were ratings of mood, hunger, and stool urgency.
Conclusion.
Diverse FAs have different effects on GE and secretion of orexigenic and anorexigenic hormones. Supplementation of 5-HTP had no effect on plasma serotonin and central functions. Further studies are needed to explain the complex interplay. |
| format | Article |
| id | doaj-art-94dce0b0098249299b45391669e77c9d |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-94dce0b0098249299b45391669e77c9d2025-02-03T01:10:50ZengWileyGastroenterology Research and Practice1687-61211687-630X2014-01-01201410.1155/2014/424503424503The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions: A Pilot ExperimentHelene Sauer0Isabelle Mack1Silke Kohler2Stefanie Siegle3Nicole Rieber4Stephan Zipfel5Bärbel Otto6Yvonne Ritze7Stephan C. Bischoff8Paul Enck9Department of Psychosomatic Medicine and Psychotherapy, University of Tuebingen, Medical Hospital, Osianderstraße 5, 72076 Tuebingen, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, University of Tuebingen, Medical Hospital, Osianderstraße 5, 72076 Tuebingen, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, University of Tuebingen, Medical Hospital, Osianderstraße 5, 72076 Tuebingen, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, University of Tuebingen, Medical Hospital, Osianderstraße 5, 72076 Tuebingen, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, University of Tuebingen, Medical Hospital, Osianderstraße 5, 72076 Tuebingen, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, University of Tuebingen, Medical Hospital, Osianderstraße 5, 72076 Tuebingen, GermanyDepartment of Internal Medicine IV, University Hospital Munich, Central Campus, Ziemssenstraße 1, 80336 Munich, GermanyDepartment of Nutritional Medicine, University of Hohenheim, Fruwirthstraße 12, 70599 Stuttgart, GermanyDepartment of Nutritional Medicine, University of Hohenheim, Fruwirthstraße 12, 70599 Stuttgart, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, University of Tuebingen, Medical Hospital, Osianderstraße 5, 72076 Tuebingen, GermanyBackground. Fat affects gastric emptying (GE). 5-Hydroxythryptophan (5-HTP) is involved in central and peripheral satiety mechanisms. Influence of 5-HTP in addition to saturated or monounsaturated fatty acids (FA) on GE and hormone release was investigated. Subjects/Methods. 24 healthy individuals (12f : 12m, 22–29 years, BMI 19–25.7 kg/m²) were tested on 4 days with either 5-HTP + short-chain saturated FA (butter), placebo + butter, 5-HTP + monounsaturated FA (olive oil), or placebo + olive oil in double-blinded randomized order. Two hours after FA/5-HTP or placebo intake, a 13C octanoid acid test was conducted. Cortisol, serotonin, cholecystokinin (CCK), and ghrelin were measured, as were mood and GE. Results. GE was delayed with butter and was normal with olive (P<0.05) but not affected by 5-HTP. 5-HTP supplementation did not affect serotonin levels. Food intake increased plasma CCK (F=6.136; P<0.05) irrespective of the FA. Ghrelin levels significantly decreased with oil/5-HTP (F=9.166; P<0.001). The diurnal cortisol profile was unaffected by FA or 5-HTP, as were ratings of mood, hunger, and stool urgency. Conclusion. Diverse FAs have different effects on GE and secretion of orexigenic and anorexigenic hormones. Supplementation of 5-HTP had no effect on plasma serotonin and central functions. Further studies are needed to explain the complex interplay.http://dx.doi.org/10.1155/2014/424503 |
| spellingShingle | Helene Sauer Isabelle Mack Silke Kohler Stefanie Siegle Nicole Rieber Stephan Zipfel Bärbel Otto Yvonne Ritze Stephan C. Bischoff Paul Enck The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions: A Pilot Experiment Gastroenterology Research and Practice |
| title | The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions: A Pilot Experiment |
| title_full | The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions: A Pilot Experiment |
| title_fullStr | The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions: A Pilot Experiment |
| title_full_unstemmed | The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions: A Pilot Experiment |
| title_short | The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions: A Pilot Experiment |
| title_sort | effects of 5 hydroxytryptophan in combination with different fatty acids on gastrointestinal functions a pilot experiment |
| url | http://dx.doi.org/10.1155/2014/424503 |
| work_keys_str_mv | AT helenesauer theeffectsof5hydroxytryptophanincombinationwithdifferentfattyacidsongastrointestinalfunctionsapilotexperiment AT isabellemack theeffectsof5hydroxytryptophanincombinationwithdifferentfattyacidsongastrointestinalfunctionsapilotexperiment AT silkekohler theeffectsof5hydroxytryptophanincombinationwithdifferentfattyacidsongastrointestinalfunctionsapilotexperiment AT stefaniesiegle theeffectsof5hydroxytryptophanincombinationwithdifferentfattyacidsongastrointestinalfunctionsapilotexperiment AT nicolerieber theeffectsof5hydroxytryptophanincombinationwithdifferentfattyacidsongastrointestinalfunctionsapilotexperiment AT stephanzipfel theeffectsof5hydroxytryptophanincombinationwithdifferentfattyacidsongastrointestinalfunctionsapilotexperiment AT barbelotto theeffectsof5hydroxytryptophanincombinationwithdifferentfattyacidsongastrointestinalfunctionsapilotexperiment AT yvonneritze theeffectsof5hydroxytryptophanincombinationwithdifferentfattyacidsongastrointestinalfunctionsapilotexperiment AT stephancbischoff theeffectsof5hydroxytryptophanincombinationwithdifferentfattyacidsongastrointestinalfunctionsapilotexperiment AT paulenck theeffectsof5hydroxytryptophanincombinationwithdifferentfattyacidsongastrointestinalfunctionsapilotexperiment AT helenesauer effectsof5hydroxytryptophanincombinationwithdifferentfattyacidsongastrointestinalfunctionsapilotexperiment AT isabellemack effectsof5hydroxytryptophanincombinationwithdifferentfattyacidsongastrointestinalfunctionsapilotexperiment AT silkekohler effectsof5hydroxytryptophanincombinationwithdifferentfattyacidsongastrointestinalfunctionsapilotexperiment AT stefaniesiegle effectsof5hydroxytryptophanincombinationwithdifferentfattyacidsongastrointestinalfunctionsapilotexperiment AT nicolerieber effectsof5hydroxytryptophanincombinationwithdifferentfattyacidsongastrointestinalfunctionsapilotexperiment AT stephanzipfel effectsof5hydroxytryptophanincombinationwithdifferentfattyacidsongastrointestinalfunctionsapilotexperiment AT barbelotto effectsof5hydroxytryptophanincombinationwithdifferentfattyacidsongastrointestinalfunctionsapilotexperiment AT yvonneritze effectsof5hydroxytryptophanincombinationwithdifferentfattyacidsongastrointestinalfunctionsapilotexperiment AT stephancbischoff effectsof5hydroxytryptophanincombinationwithdifferentfattyacidsongastrointestinalfunctionsapilotexperiment AT paulenck effectsof5hydroxytryptophanincombinationwithdifferentfattyacidsongastrointestinalfunctionsapilotexperiment |