Phenylethyl isothiocyanate mitigates drug-induced liver injury in mice by inhibiting hepatocyte pyroptosis through the NLRP3-caspase-1-GSDMD pathway

Phenylethyl isothiocyanate mitigates drug-induced liver injury in mice by inhibiting hepatocyte pyroptosis through the NLRP3-caspase-1-GSDMD pathway

Introduction: Drug-induced liver injury (DILI) represents a distinct form of hepatic damage resulting from exposure to pharmacological agents. The pathological mechanisms underlying DILI are multifaceted and remain incompletely elucidated. However, emerging evidence suggests that cell pyroptosis, a...

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Bibliographic Details
Main Authors: Ning An, Xiaoru Wang, Jia Qin, Meng Cheng, Mei Bai, Jingcai Cheng, Qiang Xu, Xuefeng Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
liver injury
triptolide
phenylethyl isothiocyanate
pyroptosis
GSDMD
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1539934/full
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