Vertigo as the First Sign of Chronic Myeloid Leukemia: A Case Report and Literature Review
Acute vestibular deficit as the first sign of leukemia is extremely rare. The literature shows some cases of sudden hearing loss accompanied by instability and associated with hyperviscosity syndrome. We present the case of a patient who presents a harmonic vestibular deficit of the right ear. The c...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Otolaryngology |
| Online Access: | http://dx.doi.org/10.1155/2013/505636 |
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| author | Rubén Martín-Hernández Diego Hernando Macías-Rodríguez Víctor Martín-Sánchez Cristina Cordero-Civantos Santiago Santa Cruz-Ruiz Ángel Batuecas-Caletrio |
| author_facet | Rubén Martín-Hernández Diego Hernando Macías-Rodríguez Víctor Martín-Sánchez Cristina Cordero-Civantos Santiago Santa Cruz-Ruiz Ángel Batuecas-Caletrio |
| author_sort | Rubén Martín-Hernández |
| collection | DOAJ |
| description | Acute vestibular deficit as the first sign of leukemia is extremely rare. The literature shows some cases of sudden hearing loss accompanied by instability and associated with hyperviscosity syndrome. We present the case of a patient who presents a harmonic vestibular deficit of the right ear. The complementary studies revealed an abnormally high level of leukocytes. A peripheral blood cytogenetic analysis is performed due to a high suspicion of leukemia, and the results show BCR/ABL fusion gene with a cut point in the M-BCR region, which confirms the diagnosis of chronic myeloid leukemia. In this case we detail the importance of taking hematological disorders into consideration in the differential diagnosis of patients with otoneurological symptoms, and we also review the etiopathogenic mechanisms, symptoms, diagnosis, and therapeutic options for chronic myeloid leukemia with sudden hearing loss and vertigo. |
| format | Article |
| id | doaj-art-94d1268c9ba2480e9effcf6a76509a2d |
| institution | Kabale University |
| issn | 2090-6765 2090-6773 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Otolaryngology |
| spelling | doaj-art-94d1268c9ba2480e9effcf6a76509a2d2025-02-03T06:01:42ZengWileyCase Reports in Otolaryngology2090-67652090-67732013-01-01201310.1155/2013/505636505636Vertigo as the First Sign of Chronic Myeloid Leukemia: A Case Report and Literature ReviewRubén Martín-Hernández0Diego Hernando Macías-Rodríguez1Víctor Martín-Sánchez2Cristina Cordero-Civantos3Santiago Santa Cruz-Ruiz4Ángel Batuecas-Caletrio5Otoneurology Unit, Department of Otorhinolaryngology and Head and Neck Pathology, University Hospital of Salamanca, Paseo San Vicente 58-182, 37007 Salamanca, SpainOtoneurology Unit, Department of Otorhinolaryngology and Head and Neck Pathology, University Hospital of Salamanca, Paseo San Vicente 58-182, 37007 Salamanca, SpainOtoneurology Unit, Department of Otorhinolaryngology and Head and Neck Pathology, University Hospital of Salamanca, Paseo San Vicente 58-182, 37007 Salamanca, SpainOtoneurology Unit, Department of Otorhinolaryngology and Head and Neck Pathology, University Hospital of Salamanca, Paseo San Vicente 58-182, 37007 Salamanca, SpainOtoneurology Unit, Department of Otorhinolaryngology and Head and Neck Pathology, University Hospital of Salamanca, Paseo San Vicente 58-182, 37007 Salamanca, SpainOtoneurology Unit, Department of Otorhinolaryngology and Head and Neck Pathology, University Hospital of Salamanca, Paseo San Vicente 58-182, 37007 Salamanca, SpainAcute vestibular deficit as the first sign of leukemia is extremely rare. The literature shows some cases of sudden hearing loss accompanied by instability and associated with hyperviscosity syndrome. We present the case of a patient who presents a harmonic vestibular deficit of the right ear. The complementary studies revealed an abnormally high level of leukocytes. A peripheral blood cytogenetic analysis is performed due to a high suspicion of leukemia, and the results show BCR/ABL fusion gene with a cut point in the M-BCR region, which confirms the diagnosis of chronic myeloid leukemia. In this case we detail the importance of taking hematological disorders into consideration in the differential diagnosis of patients with otoneurological symptoms, and we also review the etiopathogenic mechanisms, symptoms, diagnosis, and therapeutic options for chronic myeloid leukemia with sudden hearing loss and vertigo.http://dx.doi.org/10.1155/2013/505636 |
| spellingShingle | Rubén Martín-Hernández Diego Hernando Macías-Rodríguez Víctor Martín-Sánchez Cristina Cordero-Civantos Santiago Santa Cruz-Ruiz Ángel Batuecas-Caletrio Vertigo as the First Sign of Chronic Myeloid Leukemia: A Case Report and Literature Review Case Reports in Otolaryngology |
| title | Vertigo as the First Sign of Chronic Myeloid Leukemia: A Case Report and Literature Review |
| title_full | Vertigo as the First Sign of Chronic Myeloid Leukemia: A Case Report and Literature Review |
| title_fullStr | Vertigo as the First Sign of Chronic Myeloid Leukemia: A Case Report and Literature Review |
| title_full_unstemmed | Vertigo as the First Sign of Chronic Myeloid Leukemia: A Case Report and Literature Review |
| title_short | Vertigo as the First Sign of Chronic Myeloid Leukemia: A Case Report and Literature Review |
| title_sort | vertigo as the first sign of chronic myeloid leukemia a case report and literature review |
| url | http://dx.doi.org/10.1155/2013/505636 |
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