Circular RNAs in non-alcoholic fatty liver disease: Functions and clinical significance
Nonalcoholic fatty liver disease (NAFLD), which affects approximately 25% of the global population, is an urgent health issue leading to various metabolic comorbidities. Circular RNAs (circRNAs), covalently closed RNA molecules, are characterized by ubiquity, diversity, stability, and conservatism....
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | RNA Biology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/15476286.2023.2290769 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850105748663566336 |
|---|---|
| author | Qingmin Zeng Chang-Hai Liu Javier Ampuero Dongbo Wu Wei Jiang Lingyun Zhou Hong Li Lang Bai Manuel Romero-Gómez Hong Tang |
| author_facet | Qingmin Zeng Chang-Hai Liu Javier Ampuero Dongbo Wu Wei Jiang Lingyun Zhou Hong Li Lang Bai Manuel Romero-Gómez Hong Tang |
| author_sort | Qingmin Zeng |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD), which affects approximately 25% of the global population, is an urgent health issue leading to various metabolic comorbidities. Circular RNAs (circRNAs), covalently closed RNA molecules, are characterized by ubiquity, diversity, stability, and conservatism. Indeed, they participate in various biological processes via distinct mechanisms that could modify the natural history of NAFLD. In this review, we briefly introduce the biogenesis, characteristics, and biological functions of circRNAs. Furthermore, we summarize circRNAs expression profiles in NAFLD by intersecting seven sequencing data sets and describe the cellular roles of circRNAs and their potential advantages as biomarkers of NAFLD. In addition, we emphatically discuss the exosomal non-coding RNA sorting mechanisms and possible functions in recipient cells. Finally, we extensively discuss the potential application of targeting disease-related circRNAs and competing endogenous RNA networks through gain-of-function and loss-of-function approaches in targeted therapy of NAFLD. |
| format | Article |
| id | doaj-art-94d03b8d732e432b972793de0f08b2e7 |
| institution | OA Journals |
| issn | 1547-6286 1555-8584 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | RNA Biology |
| spelling | doaj-art-94d03b8d732e432b972793de0f08b2e72025-08-20T02:38:59ZengTaylor & Francis GroupRNA Biology1547-62861555-85842024-12-01211657910.1080/15476286.2023.2290769Circular RNAs in non-alcoholic fatty liver disease: Functions and clinical significanceQingmin Zeng0Chang-Hai Liu1Javier Ampuero2Dongbo Wu3Wei Jiang4Lingyun Zhou5Hong Li6Lang Bai7Manuel Romero-Gómez8Hong Tang9Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, ChinaCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, ChinaDigestive Diseases Unit, Virgen del Rocío University Hospital. SeLiver group at Institute of Biomedicine of Seville (IBIS: HUVRocío/CSIC/US). University of Seville, Seville, SpainCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, ChinaCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, ChinaCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, ChinaCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, ChinaCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, ChinaDigestive Diseases Unit, Virgen del Rocío University Hospital. SeLiver group at Institute of Biomedicine of Seville (IBIS: HUVRocío/CSIC/US). University of Seville, Seville, SpainCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, ChinaNonalcoholic fatty liver disease (NAFLD), which affects approximately 25% of the global population, is an urgent health issue leading to various metabolic comorbidities. Circular RNAs (circRNAs), covalently closed RNA molecules, are characterized by ubiquity, diversity, stability, and conservatism. Indeed, they participate in various biological processes via distinct mechanisms that could modify the natural history of NAFLD. In this review, we briefly introduce the biogenesis, characteristics, and biological functions of circRNAs. Furthermore, we summarize circRNAs expression profiles in NAFLD by intersecting seven sequencing data sets and describe the cellular roles of circRNAs and their potential advantages as biomarkers of NAFLD. In addition, we emphatically discuss the exosomal non-coding RNA sorting mechanisms and possible functions in recipient cells. Finally, we extensively discuss the potential application of targeting disease-related circRNAs and competing endogenous RNA networks through gain-of-function and loss-of-function approaches in targeted therapy of NAFLD.https://www.tandfonline.com/doi/10.1080/15476286.2023.2290769Nonalcoholic fatty liver diseasecircular RNAsfunctionsorting mechanismexosomal circRNA |
| spellingShingle | Qingmin Zeng Chang-Hai Liu Javier Ampuero Dongbo Wu Wei Jiang Lingyun Zhou Hong Li Lang Bai Manuel Romero-Gómez Hong Tang Circular RNAs in non-alcoholic fatty liver disease: Functions and clinical significance RNA Biology Nonalcoholic fatty liver disease circular RNAs function sorting mechanism exosomal circRNA |
| title | Circular RNAs in non-alcoholic fatty liver disease: Functions and clinical significance |
| title_full | Circular RNAs in non-alcoholic fatty liver disease: Functions and clinical significance |
| title_fullStr | Circular RNAs in non-alcoholic fatty liver disease: Functions and clinical significance |
| title_full_unstemmed | Circular RNAs in non-alcoholic fatty liver disease: Functions and clinical significance |
| title_short | Circular RNAs in non-alcoholic fatty liver disease: Functions and clinical significance |
| title_sort | circular rnas in non alcoholic fatty liver disease functions and clinical significance |
| topic | Nonalcoholic fatty liver disease circular RNAs function sorting mechanism exosomal circRNA |
| url | https://www.tandfonline.com/doi/10.1080/15476286.2023.2290769 |
| work_keys_str_mv | AT qingminzeng circularrnasinnonalcoholicfattyliverdiseasefunctionsandclinicalsignificance AT changhailiu circularrnasinnonalcoholicfattyliverdiseasefunctionsandclinicalsignificance AT javierampuero circularrnasinnonalcoholicfattyliverdiseasefunctionsandclinicalsignificance AT dongbowu circularrnasinnonalcoholicfattyliverdiseasefunctionsandclinicalsignificance AT weijiang circularrnasinnonalcoholicfattyliverdiseasefunctionsandclinicalsignificance AT lingyunzhou circularrnasinnonalcoholicfattyliverdiseasefunctionsandclinicalsignificance AT hongli circularrnasinnonalcoholicfattyliverdiseasefunctionsandclinicalsignificance AT langbai circularrnasinnonalcoholicfattyliverdiseasefunctionsandclinicalsignificance AT manuelromerogomez circularrnasinnonalcoholicfattyliverdiseasefunctionsandclinicalsignificance AT hongtang circularrnasinnonalcoholicfattyliverdiseasefunctionsandclinicalsignificance |