C3d-targeted complement inhibitors to correct complement dysregulation in aHUS patients

C3d-targeted complement inhibitors to correct complement dysregulation in aHUS patients

Atypical hemolytic uremic syndrome (aHUS) is a rare and severe thrombotic microangiopathy caused by genetic or acquired abnormalities leading to activation of the complement alternative pathway on cell surfaces. This process leads to endothelial dysfunction and microvascular thrombosis. The introduc...

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Bibliographic Details
Main Authors: Valeria Guaschino, Donata Santarsiero, Sara Gastoldi, Joshua M. Thurman, V. Michael Holers, Shelia M. Violette, Fei Liu, Kelly C. Fahnoe, Chiara Guarinoni, Ariela Benigni, Giuseppe Remuzzi, Marina Noris, Sistiana Aiello
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
complement system
complement inhibitors
aHUS
endothelial cell (EC)
thrombus formation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1620996/full
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