Comprehensive database and individual patient data meta-analysis of randomised controlled trials on psychotherapies reducing suicidal thoughts and behaviour: study protocol
Introduction Psychotherapy may reduce suicidal thoughts and behaviour, but its effectiveness is not well examined. Furthermore, conventional meta-analyses are unable to test possible effects of moderators affecting this relationship. This protocol outlines the building of a comprehensive database of...
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| Format: | Article |
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BMJ Publishing Group
2020-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/12/e037566.full |
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| author | Eirini Karyotaki Pim Cuijpers Derek de Beurs Helen Christensen Heleen Riper Aliza Werner-Seidler Renske Gilissen Mandy Xian Hu Christina Palantza Kim Setkowski Chani Nuij Alison Calear Anton van Balkom Merijn Eikelenboom Jan Smit Wouter van Ballegooijen |
| author_facet | Eirini Karyotaki Pim Cuijpers Derek de Beurs Helen Christensen Heleen Riper Aliza Werner-Seidler Renske Gilissen Mandy Xian Hu Christina Palantza Kim Setkowski Chani Nuij Alison Calear Anton van Balkom Merijn Eikelenboom Jan Smit Wouter van Ballegooijen |
| author_sort | Eirini Karyotaki |
| collection | DOAJ |
| description | Introduction Psychotherapy may reduce suicidal thoughts and behaviour, but its effectiveness is not well examined. Furthermore, conventional meta-analyses are unable to test possible effects of moderators affecting this relationship. This protocol outlines the building of a comprehensive database of the literature in this research field. In addition, we will conduct an individual patient data meta-analysis (IPD-MA) to establish the effectiveness of psychotherapy in reducing suicidality, and to examine which factors moderate the efficacy of these interventions.Methods and analysis To build a comprehensive database, randomised controlled trials examining the effect of any psychotherapy targeting any psychiatric disorder on suicidal thoughts or behaviour will be identified by running a systematic search in PubMed, Embase, PsycINFO, Web of Science, Scopus and The Cochrane Central Register of Controlled Trials from data inception to 12 August 2019. For the IPD-MA, we will focus on adult outpatients with suicidal ideation or behaviour. In addition, as a comparison group we will focus on a control group (waiting-list, care as usual or placebo). A 1-stage IPD-MA will be used to determine the effectiveness of psychotherapy on suicidal ideation, suicide attempts and/or suicide deaths, and to investigate potential patient-related and intervention-related moderators. Subgroup and sensitivity analyses will be conducted to test the robustness of the findings. Additionally, a conventional MA will be conducted to determine the differences between studies that provided IPD and those that did not. IPD-MA may determine the effectiveness of psychotherapy in reducing suicidality and provide insights into the moderating factors influencing the efficacy of psychotherapy. Answering these questions will inform mental healthcare practitioners about optimal treatments for different groups of individuals with suicidal ideation and/or behaviour and consequently help to reduce suicide risk.Ethics and dissemination An ethical approval is not required for this study. The results will be published in a peer-review journal.PROSPERO registration number CRD42020140573 |
| format | Article |
| id | doaj-art-94cdb7aa79544aeb8696daad41db7e00 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-94cdb7aa79544aeb8696daad41db7e002025-08-20T02:17:52ZengBMJ Publishing GroupBMJ Open2044-60552020-12-01101210.1136/bmjopen-2020-037566Comprehensive database and individual patient data meta-analysis of randomised controlled trials on psychotherapies reducing suicidal thoughts and behaviour: study protocolEirini Karyotaki0Pim Cuijpers1Derek de Beurs2Helen Christensen3Heleen Riper4Aliza Werner-Seidler5Renske Gilissen6Mandy Xian Hu7Christina Palantza8Kim Setkowski9Chani Nuij10Alison Calear11Anton van Balkom12Merijn Eikelenboom13Jan Smit14Wouter van Ballegooijen15Department of Clinical Neuro- and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, Noord-Holland, The Netherlands6 Department of Clinical, Neuro- and Developmental Psychology, VU University Amsterdam, Amsterdam, The Netherlands1 Netherlands Institute of Health Services Research (NIVEL), Utrecht, The Netherlands1 Black Dog Institute, University of New South Wales, Sydney, New South Wales, AustraliaDepartment of Clinical Neuro- and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, Noord-Holland, The Netherlands2 Black Dog Institute, University of New South Wales, Sydney, New South Wales, Australia113 Zelfmoordpreventie, Amsterdam, The NetherlandsGGZ InGeest Specialized Mental Health Care, Amsterdam, The Netherlands13 Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy113 Zelfmoordpreventie, Amsterdam, The NetherlandsDepartment of Clinical, Neuro and Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam, The NetherlandsCentre for Mental Health Research, The Australian National University, Canberra, Australian Capital Territory, AustraliaGGZ InGeest Specialized Mental Health Care, Amsterdam, The NetherlandsGGZ InGeest Specialized Mental Health Care, Amsterdam, The NetherlandsGGZ InGeest Specialized Mental Health Care, Amsterdam, The NetherlandsGGZ InGeest Specialized Mental Health Care, Amsterdam, The NetherlandsIntroduction Psychotherapy may reduce suicidal thoughts and behaviour, but its effectiveness is not well examined. Furthermore, conventional meta-analyses are unable to test possible effects of moderators affecting this relationship. This protocol outlines the building of a comprehensive database of the literature in this research field. In addition, we will conduct an individual patient data meta-analysis (IPD-MA) to establish the effectiveness of psychotherapy in reducing suicidality, and to examine which factors moderate the efficacy of these interventions.Methods and analysis To build a comprehensive database, randomised controlled trials examining the effect of any psychotherapy targeting any psychiatric disorder on suicidal thoughts or behaviour will be identified by running a systematic search in PubMed, Embase, PsycINFO, Web of Science, Scopus and The Cochrane Central Register of Controlled Trials from data inception to 12 August 2019. For the IPD-MA, we will focus on adult outpatients with suicidal ideation or behaviour. In addition, as a comparison group we will focus on a control group (waiting-list, care as usual or placebo). A 1-stage IPD-MA will be used to determine the effectiveness of psychotherapy on suicidal ideation, suicide attempts and/or suicide deaths, and to investigate potential patient-related and intervention-related moderators. Subgroup and sensitivity analyses will be conducted to test the robustness of the findings. Additionally, a conventional MA will be conducted to determine the differences between studies that provided IPD and those that did not. IPD-MA may determine the effectiveness of psychotherapy in reducing suicidality and provide insights into the moderating factors influencing the efficacy of psychotherapy. Answering these questions will inform mental healthcare practitioners about optimal treatments for different groups of individuals with suicidal ideation and/or behaviour and consequently help to reduce suicide risk.Ethics and dissemination An ethical approval is not required for this study. The results will be published in a peer-review journal.PROSPERO registration number CRD42020140573https://bmjopen.bmj.com/content/10/12/e037566.full |
| spellingShingle | Eirini Karyotaki Pim Cuijpers Derek de Beurs Helen Christensen Heleen Riper Aliza Werner-Seidler Renske Gilissen Mandy Xian Hu Christina Palantza Kim Setkowski Chani Nuij Alison Calear Anton van Balkom Merijn Eikelenboom Jan Smit Wouter van Ballegooijen Comprehensive database and individual patient data meta-analysis of randomised controlled trials on psychotherapies reducing suicidal thoughts and behaviour: study protocol BMJ Open |
| title | Comprehensive database and individual patient data meta-analysis of randomised controlled trials on psychotherapies reducing suicidal thoughts and behaviour: study protocol |
| title_full | Comprehensive database and individual patient data meta-analysis of randomised controlled trials on psychotherapies reducing suicidal thoughts and behaviour: study protocol |
| title_fullStr | Comprehensive database and individual patient data meta-analysis of randomised controlled trials on psychotherapies reducing suicidal thoughts and behaviour: study protocol |
| title_full_unstemmed | Comprehensive database and individual patient data meta-analysis of randomised controlled trials on psychotherapies reducing suicidal thoughts and behaviour: study protocol |
| title_short | Comprehensive database and individual patient data meta-analysis of randomised controlled trials on psychotherapies reducing suicidal thoughts and behaviour: study protocol |
| title_sort | comprehensive database and individual patient data meta analysis of randomised controlled trials on psychotherapies reducing suicidal thoughts and behaviour study protocol |
| url | https://bmjopen.bmj.com/content/10/12/e037566.full |
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