Does outdoor light contribute to ovarian cancer mortality? Insights from a case-control study
Unfavorable light environments, including artificial light at night (ALAN) and ultraviolet B (UVB) radiation, may be linked to ovarian cancer, but this association remains uncertain. A multicenter case-control study in Northeastern China was performed. Using propensity score matching, we matched ind...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325008358 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Unfavorable light environments, including artificial light at night (ALAN) and ultraviolet B (UVB) radiation, may be linked to ovarian cancer, but this association remains uncertain. A multicenter case-control study in Northeastern China was performed. Using propensity score matching, we matched individuals who died from other cancers with controls in a 1:1 ratio. Exposure levels were determined by monthly average outdoor ALAN exposure (0.5 ×0.5 km), UVB radiation (0.25°×0.25°), and PM2.5 (1 ×1 km) based on each participant's residential address. Conditional logistic regression models were employed to analyze the association between light exposure (1–5 years prior to death) and ovarian cancer mortality. A total of 2159 ovarian cancer deaths and an equal number of controls were included in the study. The average exposure of ALAN and UVB over the 5 years prior to death ranged from 0.1 to 130.3 nw/cm²/sr and 29.1–53.4 W/m2, respectively. ALAN exposure was positively associated with ovarian cancer mortality. For example, with 5-year exposure, compared to the lowest quintile (Q1), the hazard ratios (HR) for the second to fifth quintiles (Q2–Q5) were 1.51 (95 % CI: 1.13–2.02), 1.69 (95 % CI: 1.23–2.33), 1.79 (95 % CI: 1.29–2.49), and 1.67 (95 % CI: 1.20–2.33), respectively. However, UVB exposure showed only suggestive evidence of a protective effect. Additionally, PM2.5 exposure emerged as a significant risk factor for ovarian cancer mortality in urban populations. ALAN exposure may serve as a risk factor for ovarian cancer mortality, while PM2.5 exposure also appears to be a significant risk factor in urban areas. |
|---|---|
| ISSN: | 0147-6513 |