Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis
Oral submucous fibrosis (OSF) is a potentially malignant disorder which causes fibrosis and inflammation of the oral mucosa. Studies have reported altered levels of trace elements in oral submucous fibrosis subjects, but findings have been inconsistent. The objective of this research is to perform a...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2018/3472087 |
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| author | Prageet K. Sachdev Jeanne Freeland-Graves S. Natasha Beretvas Namrata Sanjeevi |
| author_facet | Prageet K. Sachdev Jeanne Freeland-Graves S. Natasha Beretvas Namrata Sanjeevi |
| author_sort | Prageet K. Sachdev |
| collection | DOAJ |
| description | Oral submucous fibrosis (OSF) is a potentially malignant disorder which causes fibrosis and inflammation of the oral mucosa. Studies have reported altered levels of trace elements in oral submucous fibrosis subjects, but findings have been inconsistent. The objective of this research is to perform a meta-analysis to summarize studies that report zinc (Zn), copper (Cu), and iron (Fe) in patients, with and without OSF. A literature search of Embase, PubMed, Cochrane Library, and Web of Science electronic databases was conducted for studies up to January 2017. A total of 34 reports met the inclusion criteria. The standardized mean difference was utilized as the effect size. The robust variance estimation method was chosen to handle dependency of multiple related outcomes in meta-analysis. There was a significant increase in the levels of Cu (effect size = 1.17, p value < 0.05, 95% confidence interval (CI): 0.164–2.171) and a significant decrease in levels of Zn (effect size = −1.95, p value < 0.05, 95% CI: −3.524 to −0.367) and Fe (effect size = −2.77, p value < 0.01, 95% CI: −4.126 to −1.406) in OSF patients. The estimation of Zn, Cu, and Fe levels may serve as additional biomarkers in the diagnosis and prognosis of OSF along with the clinical features. |
| format | Article |
| id | doaj-art-94ca8a85f3d944e09bc129e7652484fc |
| institution | OA Journals |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
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| series | International Journal of Dentistry |
| spelling | doaj-art-94ca8a85f3d944e09bc129e7652484fc2025-08-20T02:09:48ZengWileyInternational Journal of Dentistry1687-87281687-87362018-01-01201810.1155/2018/34720873472087Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-AnalysisPrageet K. Sachdev0Jeanne Freeland-Graves1S. Natasha Beretvas2Namrata Sanjeevi3Department of Nutritional Sciences, College of Natural Sciences, The University of Texas at Austin, 103 W. 24th St. A2703, Austin, TX 78712, USADepartment of Nutritional Sciences, College of Natural Sciences, The University of Texas at Austin, 103 W. 24th St. A2703, Austin, TX 78712, USADepartment of Educational Psychology, The University of Texas at Austin, George I. Sánchez Building 538E, 1912 Speedway, Austin, TX 78712, USADepartment of Nutritional Sciences, College of Natural Sciences, The University of Texas at Austin, 103 W. 24th St. A2703, Austin, TX 78712, USAOral submucous fibrosis (OSF) is a potentially malignant disorder which causes fibrosis and inflammation of the oral mucosa. Studies have reported altered levels of trace elements in oral submucous fibrosis subjects, but findings have been inconsistent. The objective of this research is to perform a meta-analysis to summarize studies that report zinc (Zn), copper (Cu), and iron (Fe) in patients, with and without OSF. A literature search of Embase, PubMed, Cochrane Library, and Web of Science electronic databases was conducted for studies up to January 2017. A total of 34 reports met the inclusion criteria. The standardized mean difference was utilized as the effect size. The robust variance estimation method was chosen to handle dependency of multiple related outcomes in meta-analysis. There was a significant increase in the levels of Cu (effect size = 1.17, p value < 0.05, 95% confidence interval (CI): 0.164–2.171) and a significant decrease in levels of Zn (effect size = −1.95, p value < 0.05, 95% CI: −3.524 to −0.367) and Fe (effect size = −2.77, p value < 0.01, 95% CI: −4.126 to −1.406) in OSF patients. The estimation of Zn, Cu, and Fe levels may serve as additional biomarkers in the diagnosis and prognosis of OSF along with the clinical features.http://dx.doi.org/10.1155/2018/3472087 |
| spellingShingle | Prageet K. Sachdev Jeanne Freeland-Graves S. Natasha Beretvas Namrata Sanjeevi Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis International Journal of Dentistry |
| title | Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis |
| title_full | Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis |
| title_fullStr | Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis |
| title_full_unstemmed | Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis |
| title_short | Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis |
| title_sort | zinc copper and iron in oral submucous fibrosis a meta analysis |
| url | http://dx.doi.org/10.1155/2018/3472087 |
| work_keys_str_mv | AT prageetksachdev zinccopperandironinoralsubmucousfibrosisametaanalysis AT jeannefreelandgraves zinccopperandironinoralsubmucousfibrosisametaanalysis AT snatashaberetvas zinccopperandironinoralsubmucousfibrosisametaanalysis AT namratasanjeevi zinccopperandironinoralsubmucousfibrosisametaanalysis |