Association of myocardial and liver T2* iron measurements with systolic and diastolic function by CMR feature tracking strain analysis
Background/ObjectivesMyocardial and liver iron overload can be assessed through T2* in magnetic resonance imaging (MRI). It is unclear, how T2* measurements are associated with systolic and diastolic left ventricular function assessed by novel feature tracking (FT) strain.MethodsConsecutive patients...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1547161/full |
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| author | Hugo G. Quezada-Pinedo Benedikt Bernhard Jan C. Zurkirchen Anselm W. Stark Noushin Sadat Ahanchi Noushin Sadat Ahanchi Catherine Gebhard Daniel Ott Alan A. Peters Hendrik von Tengg-Kobligk Jonathan Schütze Adam Bakula Andreas Wahl Kim N. Cajachagua-Torres Taulant Muka Christoph Gräni |
| author_facet | Hugo G. Quezada-Pinedo Benedikt Bernhard Jan C. Zurkirchen Anselm W. Stark Noushin Sadat Ahanchi Noushin Sadat Ahanchi Catherine Gebhard Daniel Ott Alan A. Peters Hendrik von Tengg-Kobligk Jonathan Schütze Adam Bakula Andreas Wahl Kim N. Cajachagua-Torres Taulant Muka Christoph Gräni |
| author_sort | Hugo G. Quezada-Pinedo |
| collection | DOAJ |
| description | Background/ObjectivesMyocardial and liver iron overload can be assessed through T2* in magnetic resonance imaging (MRI). It is unclear, how T2* measurements are associated with systolic and diastolic left ventricular function assessed by novel feature tracking (FT) strain.MethodsConsecutive patients with suspected iron overload undergoing MRI T2* were retrospectively included. T2* was studied continuously and in categories: normal myocardial iron status (T2* ≥ 20 ms), myocardial iron overload (T2* < 20 ms), normal liver iron status (T2* ≥ 15.4 ms) and liver iron overload (T2* < 15.4 ms). Multivariable regression models were used to assess associations between T2* and FT strain.ResultsAmong 172 participants, longitudinal e/a ratio [−0.17 (−0.27, −0.08), p = 0.001], longitudinal early diastolic strain rate [−0.13 (−0.23, −0.03), p = 0.014], circumferential late diastolic strain rate [0.18 (0.03, 0.32), p = 0.016], longitudinal late diastolic strain rate [0.20 (0.03, 0.36), p = 0.019] were associated with higher T2*. Liver iron overload was associated with circumferential systolic strain rate [−0.42 (−0.74, −0.09), p = 0.014] and longitudinal early diastolic strain rate [0.27 (0.04, 0.49), p = 0.023]. Combined liver and myocardial iron overload were associated with longitudinal e/a ratio [0.72 (0.19, 1.24), p = 0.008]. No associations of T2* values with systolic function were found.ConclusionLiver and a combination of myocardial and liver iron overload were associated with increased early diastolic filling and increased e/a ratio respectively, which may serve as markers of diastolic dysfunction. Impaired diastolic function, even in the absence of myocardial iron overload was associated with liver iron metabolism and may indicate early cardiac involvement, while left ventricular systolic function is still preserved. |
| format | Article |
| id | doaj-art-94c885331d1a49b0b84d99c204f6b5e7 |
| institution | DOAJ |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-94c885331d1a49b0b84d99c204f6b5e72025-08-20T03:02:28ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-03-011210.3389/fcvm.2025.15471611547161Association of myocardial and liver T2* iron measurements with systolic and diastolic function by CMR feature tracking strain analysisHugo G. Quezada-Pinedo0Benedikt Bernhard1Jan C. Zurkirchen2Anselm W. Stark3Noushin Sadat Ahanchi4Noushin Sadat Ahanchi5Catherine Gebhard6Daniel Ott7Alan A. Peters8Hendrik von Tengg-Kobligk9Jonathan Schütze10Adam Bakula11Andreas Wahl12Kim N. Cajachagua-Torres13Taulant Muka14Christoph Gräni15Department of Population Health Sciences, Duke University School of Medicine, Durham, NC, United StatesDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, SwitzerlandInstitute of Social and Preventive Medicine (ISPM), Graduate School of Health Sciences, University of Bern, Bern, SwitzerlandGraduate School for Health Sciences, University of Bern, Bern, SwitzerlandDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC, United StatesDepartment of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Pediatrics, New York University Grossman of Medicine, New York University, New York, NY, United StatesEpistudia, Bern, SwitzerlandDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, SwitzerlandBackground/ObjectivesMyocardial and liver iron overload can be assessed through T2* in magnetic resonance imaging (MRI). It is unclear, how T2* measurements are associated with systolic and diastolic left ventricular function assessed by novel feature tracking (FT) strain.MethodsConsecutive patients with suspected iron overload undergoing MRI T2* were retrospectively included. T2* was studied continuously and in categories: normal myocardial iron status (T2* ≥ 20 ms), myocardial iron overload (T2* < 20 ms), normal liver iron status (T2* ≥ 15.4 ms) and liver iron overload (T2* < 15.4 ms). Multivariable regression models were used to assess associations between T2* and FT strain.ResultsAmong 172 participants, longitudinal e/a ratio [−0.17 (−0.27, −0.08), p = 0.001], longitudinal early diastolic strain rate [−0.13 (−0.23, −0.03), p = 0.014], circumferential late diastolic strain rate [0.18 (0.03, 0.32), p = 0.016], longitudinal late diastolic strain rate [0.20 (0.03, 0.36), p = 0.019] were associated with higher T2*. Liver iron overload was associated with circumferential systolic strain rate [−0.42 (−0.74, −0.09), p = 0.014] and longitudinal early diastolic strain rate [0.27 (0.04, 0.49), p = 0.023]. Combined liver and myocardial iron overload were associated with longitudinal e/a ratio [0.72 (0.19, 1.24), p = 0.008]. No associations of T2* values with systolic function were found.ConclusionLiver and a combination of myocardial and liver iron overload were associated with increased early diastolic filling and increased e/a ratio respectively, which may serve as markers of diastolic dysfunction. Impaired diastolic function, even in the absence of myocardial iron overload was associated with liver iron metabolism and may indicate early cardiac involvement, while left ventricular systolic function is still preserved.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1547161/fullT2*iron overloadretrospective studiesfeature trackingstraindiastolic function |
| spellingShingle | Hugo G. Quezada-Pinedo Benedikt Bernhard Jan C. Zurkirchen Anselm W. Stark Noushin Sadat Ahanchi Noushin Sadat Ahanchi Catherine Gebhard Daniel Ott Alan A. Peters Hendrik von Tengg-Kobligk Jonathan Schütze Adam Bakula Andreas Wahl Kim N. Cajachagua-Torres Taulant Muka Christoph Gräni Association of myocardial and liver T2* iron measurements with systolic and diastolic function by CMR feature tracking strain analysis Frontiers in Cardiovascular Medicine T2* iron overload retrospective studies feature tracking strain diastolic function |
| title | Association of myocardial and liver T2* iron measurements with systolic and diastolic function by CMR feature tracking strain analysis |
| title_full | Association of myocardial and liver T2* iron measurements with systolic and diastolic function by CMR feature tracking strain analysis |
| title_fullStr | Association of myocardial and liver T2* iron measurements with systolic and diastolic function by CMR feature tracking strain analysis |
| title_full_unstemmed | Association of myocardial and liver T2* iron measurements with systolic and diastolic function by CMR feature tracking strain analysis |
| title_short | Association of myocardial and liver T2* iron measurements with systolic and diastolic function by CMR feature tracking strain analysis |
| title_sort | association of myocardial and liver t2 iron measurements with systolic and diastolic function by cmr feature tracking strain analysis |
| topic | T2* iron overload retrospective studies feature tracking strain diastolic function |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1547161/full |
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