Hormone Receptors in Cervicovaginal Cells
Some parts of the female reproductive system such as vagina and ectocervix is covered with stratified squamous epithelium (SSE). SSE consists of many layers and steroid hormones are essential for its normal growth and development. The steroid hormones mediate their effects via intracellular resepto...
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| Language: | English |
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Medical Network
2013-04-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/188 |
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| author | Şayeste Demirezen Funda Gerçeker Sinan Beksaç |
| author_facet | Şayeste Demirezen Funda Gerçeker Sinan Beksaç |
| author_sort | Şayeste Demirezen |
| collection | DOAJ |
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Some parts of the female reproductive system such as vagina and ectocervix is covered with stratified squamous epithelium (SSE). SSE consists of many layers and steroid hormones are essential for its normal growth and development. The steroid hormones mediate their effects via intracellular reseptors (3P). These are estrogen receptors, progesterone receptors and androgen receptors. These are found in cytoplasm or nucleus, or both. The steroid hormone receptors are made up of three functional domains: N-terminal domain (NTD), DNA binding domain (DBD) and ligand-binding domain (LBD). Initially, the steroid hormones diffuse into the cell and bind to its spesific receptor protein. Afterwards, hormone-bound receptor dimerizes with another receptor and then the dimer binds to specific DNA sequence through the DBD. Consequently, hormones regulate gene transcription via a direct interaction with DNA. In this review, we will give detailed information about SSE cells, hormone receptors, structure of the receptors and mechanism of their action.
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| format | Article |
| id | doaj-art-94c5cdf00cb54e699764d6a5eb69dd47 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2013-04-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-94c5cdf00cb54e699764d6a5eb69dd472025-02-11T21:20:03ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182013-04-01191127Hormone Receptors in Cervicovaginal CellsŞayeste Demirezen0Funda Gerçeker1Sinan Beksaç2Hacettepe University Faculty of Natural & Applied Science Department of Biology, BeytepeHacettepe University Faculty of Natural & Applied Science Department of Biology, BeytepeHacettepe University Faculty of Medicine Department of Obstetrics and Gynecology, Ankara Some parts of the female reproductive system such as vagina and ectocervix is covered with stratified squamous epithelium (SSE). SSE consists of many layers and steroid hormones are essential for its normal growth and development. The steroid hormones mediate their effects via intracellular reseptors (3P). These are estrogen receptors, progesterone receptors and androgen receptors. These are found in cytoplasm or nucleus, or both. The steroid hormone receptors are made up of three functional domains: N-terminal domain (NTD), DNA binding domain (DBD) and ligand-binding domain (LBD). Initially, the steroid hormones diffuse into the cell and bind to its spesific receptor protein. Afterwards, hormone-bound receptor dimerizes with another receptor and then the dimer binds to specific DNA sequence through the DBD. Consequently, hormones regulate gene transcription via a direct interaction with DNA. In this review, we will give detailed information about SSE cells, hormone receptors, structure of the receptors and mechanism of their action. https://gorm.com.tr/index.php/GORM/article/view/188Steroid hormone receptorsEstrogen receptorsProgesterone receptorsAndrogen receptors |
| spellingShingle | Şayeste Demirezen Funda Gerçeker Sinan Beksaç Hormone Receptors in Cervicovaginal Cells Gynecology Obstetrics & Reproductive Medicine Steroid hormone receptors Estrogen receptors Progesterone receptors Androgen receptors |
| title | Hormone Receptors in Cervicovaginal Cells |
| title_full | Hormone Receptors in Cervicovaginal Cells |
| title_fullStr | Hormone Receptors in Cervicovaginal Cells |
| title_full_unstemmed | Hormone Receptors in Cervicovaginal Cells |
| title_short | Hormone Receptors in Cervicovaginal Cells |
| title_sort | hormone receptors in cervicovaginal cells |
| topic | Steroid hormone receptors Estrogen receptors Progesterone receptors Androgen receptors |
| url | https://gorm.com.tr/index.php/GORM/article/view/188 |
| work_keys_str_mv | AT sayestedemirezen hormonereceptorsincervicovaginalcells AT fundagerceker hormonereceptorsincervicovaginalcells AT sinanbeksac hormonereceptorsincervicovaginalcells |