A rare case of vision loss caused by leptomeningeal metastasis of lung adenocarcinoma: a case report and literature review
Leptomeningeal metastasis (LM) is a fatal complication with increasing incidence in patients with non-small cell lung cancer. Herein, we present the case of a patient who presented with complete vision loss due to LM and achieved a survival benefit from treatment with trametinib. The treatment was p...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1484383/full |
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| author | Zhihua Li Jian Chu Wennan Shen Junnan Chen Yuemei Dong Manze Zhang Nan Zhao Wei Zhao Haoran Zha Ning Wang Yalin Han Zhaoxia Li |
| author_facet | Zhihua Li Jian Chu Wennan Shen Junnan Chen Yuemei Dong Manze Zhang Nan Zhao Wei Zhao Haoran Zha Ning Wang Yalin Han Zhaoxia Li |
| author_sort | Zhihua Li |
| collection | DOAJ |
| description | Leptomeningeal metastasis (LM) is a fatal complication with increasing incidence in patients with non-small cell lung cancer. Herein, we present the case of a patient who presented with complete vision loss due to LM and achieved a survival benefit from treatment with trametinib. The treatment was prescribed based on the detection of a BRAF non-V600E mutation in the cerebrospinal fluid (CSF). We reviewed the literature and evaluated survival benefits in patients with LM harboring BRAF non-V600E mutations treated with CSF chemotherapy and mitogen-activated extracellular signal-regulated kinase inhibitors. |
| format | Article |
| id | doaj-art-94bad32213a74aabbf4b56c66f35de15 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-94bad32213a74aabbf4b56c66f35de152025-02-10T05:16:12ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.14843831484383A rare case of vision loss caused by leptomeningeal metastasis of lung adenocarcinoma: a case report and literature reviewZhihua LiJian ChuWennan ShenJunnan ChenYuemei DongManze ZhangNan ZhaoWei ZhaoHaoran ZhaNing WangYalin HanZhaoxia LiLeptomeningeal metastasis (LM) is a fatal complication with increasing incidence in patients with non-small cell lung cancer. Herein, we present the case of a patient who presented with complete vision loss due to LM and achieved a survival benefit from treatment with trametinib. The treatment was prescribed based on the detection of a BRAF non-V600E mutation in the cerebrospinal fluid (CSF). We reviewed the literature and evaluated survival benefits in patients with LM harboring BRAF non-V600E mutations treated with CSF chemotherapy and mitogen-activated extracellular signal-regulated kinase inhibitors.https://www.frontiersin.org/articles/10.3389/fonc.2025.1484383/fullleptomeningeal metastasisBRAF non-V600E mutationNSCLCtrametinibvision losscase report |
| spellingShingle | Zhihua Li Jian Chu Wennan Shen Junnan Chen Yuemei Dong Manze Zhang Nan Zhao Wei Zhao Haoran Zha Ning Wang Yalin Han Zhaoxia Li A rare case of vision loss caused by leptomeningeal metastasis of lung adenocarcinoma: a case report and literature review Frontiers in Oncology leptomeningeal metastasis BRAF non-V600E mutation NSCLC trametinib vision loss case report |
| title | A rare case of vision loss caused by leptomeningeal metastasis of lung adenocarcinoma: a case report and literature review |
| title_full | A rare case of vision loss caused by leptomeningeal metastasis of lung adenocarcinoma: a case report and literature review |
| title_fullStr | A rare case of vision loss caused by leptomeningeal metastasis of lung adenocarcinoma: a case report and literature review |
| title_full_unstemmed | A rare case of vision loss caused by leptomeningeal metastasis of lung adenocarcinoma: a case report and literature review |
| title_short | A rare case of vision loss caused by leptomeningeal metastasis of lung adenocarcinoma: a case report and literature review |
| title_sort | rare case of vision loss caused by leptomeningeal metastasis of lung adenocarcinoma a case report and literature review |
| topic | leptomeningeal metastasis BRAF non-V600E mutation NSCLC trametinib vision loss case report |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1484383/full |
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