Ferroptosis as an emerging target in sickle cell disease
Sickle cell disease (SCD) is an inherited hemoglobin disorder marked by red blood cell sickling, resulting in severe anemia, painful episodes, extensive organ damage, and shortened life expectancy. In SCD, increased iron levels can trigger ferroptosis, a specific type of cell death characterized by...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Current Research in Toxicology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666027X24000343 |
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| author | Vitor Fortuna Jaqueline Lima Gabriel F. Oliveira Yasmin S. Oliveira Bruk Getachew Sergei Nekhai Michael Aschner Yousef Tizabi |
| author_facet | Vitor Fortuna Jaqueline Lima Gabriel F. Oliveira Yasmin S. Oliveira Bruk Getachew Sergei Nekhai Michael Aschner Yousef Tizabi |
| author_sort | Vitor Fortuna |
| collection | DOAJ |
| description | Sickle cell disease (SCD) is an inherited hemoglobin disorder marked by red blood cell sickling, resulting in severe anemia, painful episodes, extensive organ damage, and shortened life expectancy. In SCD, increased iron levels can trigger ferroptosis, a specific type of cell death characterized by reactive oxygen species (ROS) and lipid peroxide accumulation, leading to damage and organ impairments. The intricate interplay between iron, ferroptosis, inflammation, and oxidative stress in SCD underscores the necessity of thoroughly understanding these processes for the development of innovative therapeutic strategies. This review highlights the importance of balancing the complex interactions among various factors and exploitation of the knowledge in developing novel therapeutics for this devastating disease. |
| format | Article |
| id | doaj-art-94b5b2894d3345ffbb48fdaddd17a9fb |
| institution | OA Journals |
| issn | 2666-027X |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Toxicology |
| spelling | doaj-art-94b5b2894d3345ffbb48fdaddd17a9fb2025-08-20T02:37:48ZengElsevierCurrent Research in Toxicology2666-027X2024-01-01710018110.1016/j.crtox.2024.100181Ferroptosis as an emerging target in sickle cell diseaseVitor Fortuna0Jaqueline Lima1Gabriel F. Oliveira2Yasmin S. Oliveira3Bruk Getachew4Sergei Nekhai5Michael Aschner6Yousef Tizabi7Department of Biochemistry and Biophysics, Health Sciences Institute, Federal University of Bahia, BA 40231-300, Brazil; Postgraduate Program in Immunology, Health Sciences Institute, Federal University of Bahia, BA 40231-300, BrazilPostgraduate Program in Immunology, Health Sciences Institute, Federal University of Bahia, BA 40231-300, BrazilPostgraduate Program in Immunology, Health Sciences Institute, Federal University of Bahia, BA 40231-300, BrazilPostgraduate Program in Immunology, Health Sciences Institute, Federal University of Bahia, BA 40231-300, BrazilDepartment of Pharmacology, Howard University College of Medicine, Washington, DC, USACenter for Sickle Cell Disease, Departments of Microbiology and Medicine, Howard University College of Medicine, Washington, DC, USADepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USADepartment of Pharmacology, Howard University College of Medicine, Washington, DC, USA; Corresponding author at: Department of Pharmacology, Howard University College of Medicine, 520 W Street NW, Washington, DC, 20059, USA.Sickle cell disease (SCD) is an inherited hemoglobin disorder marked by red blood cell sickling, resulting in severe anemia, painful episodes, extensive organ damage, and shortened life expectancy. In SCD, increased iron levels can trigger ferroptosis, a specific type of cell death characterized by reactive oxygen species (ROS) and lipid peroxide accumulation, leading to damage and organ impairments. The intricate interplay between iron, ferroptosis, inflammation, and oxidative stress in SCD underscores the necessity of thoroughly understanding these processes for the development of innovative therapeutic strategies. This review highlights the importance of balancing the complex interactions among various factors and exploitation of the knowledge in developing novel therapeutics for this devastating disease.http://www.sciencedirect.com/science/article/pii/S2666027X24000343Sickle cell diseaseIron toxicityFerroptosisOxidative stressLipid peroxidationNovel targets |
| spellingShingle | Vitor Fortuna Jaqueline Lima Gabriel F. Oliveira Yasmin S. Oliveira Bruk Getachew Sergei Nekhai Michael Aschner Yousef Tizabi Ferroptosis as an emerging target in sickle cell disease Current Research in Toxicology Sickle cell disease Iron toxicity Ferroptosis Oxidative stress Lipid peroxidation Novel targets |
| title | Ferroptosis as an emerging target in sickle cell disease |
| title_full | Ferroptosis as an emerging target in sickle cell disease |
| title_fullStr | Ferroptosis as an emerging target in sickle cell disease |
| title_full_unstemmed | Ferroptosis as an emerging target in sickle cell disease |
| title_short | Ferroptosis as an emerging target in sickle cell disease |
| title_sort | ferroptosis as an emerging target in sickle cell disease |
| topic | Sickle cell disease Iron toxicity Ferroptosis Oxidative stress Lipid peroxidation Novel targets |
| url | http://www.sciencedirect.com/science/article/pii/S2666027X24000343 |
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