Zoonotic tuberculosis in Catalonia, Spain: Phylogenetic insights into Mycobacterium bovis and M. caprae transmission at the human-livestock interface

This genomic epidemiology study analyzed Mycobacterium bovis and M. caprae isolates from animals and humans in Catalonia, Spain, between 2005 and 2023. Of 42 human tuberculosis (TB) cases, five were phylogenetically linked to livestock outbreaks, suggesting zoonotic transmission. The findings specif...

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Main Authors: Bernat Pérez de Val, Enric Vidal, Tod Stuber, Jose Luís Sáez, María Teresa Tórtola
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:One Health
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Online Access:http://www.sciencedirect.com/science/article/pii/S2352771425000291
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author Bernat Pérez de Val
Enric Vidal
Tod Stuber
Jose Luís Sáez
María Teresa Tórtola
author_facet Bernat Pérez de Val
Enric Vidal
Tod Stuber
Jose Luís Sáez
María Teresa Tórtola
author_sort Bernat Pérez de Val
collection DOAJ
description This genomic epidemiology study analyzed Mycobacterium bovis and M. caprae isolates from animals and humans in Catalonia, Spain, between 2005 and 2023. Of 42 human tuberculosis (TB) cases, five were phylogenetically linked to livestock outbreaks, suggesting zoonotic transmission. The findings specifically indicate goats as a primary source of M. caprae transmission to humans. The study also revealed unexpected genetic diversity of mycobacteria within the same outbreak or even within the same patient, highlighting the complexity of tuberculosis transmission dynamics. The results underscore the value of genomic surveillance in understanding zoonotic TB transmission at the human-livestock interface and its role in informing effective control strategies.
format Article
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issn 2352-7714
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publishDate 2025-06-01
publisher Elsevier
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series One Health
spelling doaj-art-94b4b4f5afa04d67a61e3289ee3de5962025-08-20T02:08:02ZengElsevierOne Health2352-77142025-06-012010099310.1016/j.onehlt.2025.100993Zoonotic tuberculosis in Catalonia, Spain: Phylogenetic insights into Mycobacterium bovis and M. caprae transmission at the human-livestock interfaceBernat Pérez de Val0Enric Vidal1Tod Stuber2Jose Luís Sáez3María Teresa Tórtola4IRTA, Animal Health, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), 08193, Bellaterra, Catalonia, Spain; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, CReSA, Campus de la UAB, Bellaterra, Catalonia, Spain; WOAH Collaborating Centre for the Research and Control of Emerging and Re-Emerging Swine Diseases in Europe (IRTA-CReSA), Bellaterra, Catalonia, Spain; Corresponding author at: IRTA, Animal Health, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.IRTA, Animal Health, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), 08193, Bellaterra, Catalonia, Spain; Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, CReSA, Campus de la UAB, Bellaterra, Catalonia, Spain; WOAH Collaborating Centre for the Research and Control of Emerging and Re-Emerging Swine Diseases in Europe (IRTA-CReSA), Bellaterra, Catalonia, SpainNational Veterinary Services Laboratories, U.S. Department of Agriculture, Animal and Plant Health Inspection Service, Veterinary Services, Ames, IA, USASubdirección General de Sanidad e Higiene Animal y Trazabilidad, Dirección General de Sanidad de la Producción Agraria, Ministerio de Agricultura, Pesca y Alimentación, Madrid, SpainMicrobiology Service, WHO Supranational TB Reference Laboratory, Vall d'Hebron University Hospital (HUVH), Vall d'Hebron Research Institute (VHIR), Barcelona, Catalonia, Spain; CIBER of Infectious Diseases (CIBERINFEC), Instituto de Salud Carlos III, Madrid, SpainThis genomic epidemiology study analyzed Mycobacterium bovis and M. caprae isolates from animals and humans in Catalonia, Spain, between 2005 and 2023. Of 42 human tuberculosis (TB) cases, five were phylogenetically linked to livestock outbreaks, suggesting zoonotic transmission. The findings specifically indicate goats as a primary source of M. caprae transmission to humans. The study also revealed unexpected genetic diversity of mycobacteria within the same outbreak or even within the same patient, highlighting the complexity of tuberculosis transmission dynamics. The results underscore the value of genomic surveillance in understanding zoonotic TB transmission at the human-livestock interface and its role in informing effective control strategies.http://www.sciencedirect.com/science/article/pii/S2352771425000291Zoonotic tuberculosisMycobacterium bovisMycobacterium capraeWhole genome sequencingGenomic epidemiologyCattle
spellingShingle Bernat Pérez de Val
Enric Vidal
Tod Stuber
Jose Luís Sáez
María Teresa Tórtola
Zoonotic tuberculosis in Catalonia, Spain: Phylogenetic insights into Mycobacterium bovis and M. caprae transmission at the human-livestock interface
One Health
Zoonotic tuberculosis
Mycobacterium bovis
Mycobacterium caprae
Whole genome sequencing
Genomic epidemiology
Cattle
title Zoonotic tuberculosis in Catalonia, Spain: Phylogenetic insights into Mycobacterium bovis and M. caprae transmission at the human-livestock interface
title_full Zoonotic tuberculosis in Catalonia, Spain: Phylogenetic insights into Mycobacterium bovis and M. caprae transmission at the human-livestock interface
title_fullStr Zoonotic tuberculosis in Catalonia, Spain: Phylogenetic insights into Mycobacterium bovis and M. caprae transmission at the human-livestock interface
title_full_unstemmed Zoonotic tuberculosis in Catalonia, Spain: Phylogenetic insights into Mycobacterium bovis and M. caprae transmission at the human-livestock interface
title_short Zoonotic tuberculosis in Catalonia, Spain: Phylogenetic insights into Mycobacterium bovis and M. caprae transmission at the human-livestock interface
title_sort zoonotic tuberculosis in catalonia spain phylogenetic insights into mycobacterium bovis and m caprae transmission at the human livestock interface
topic Zoonotic tuberculosis
Mycobacterium bovis
Mycobacterium caprae
Whole genome sequencing
Genomic epidemiology
Cattle
url http://www.sciencedirect.com/science/article/pii/S2352771425000291
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