The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages
Inflammation is a complex biological response of tissues to harmful stimuli such as pathogens, cell damage, or irritants. Inflammation is considered to be a major cause of most chronic diseases, especially in more than 100 types of inflammatory diseases which include Alzheimer's disease, rheuma...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/979105 |
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| _version_ | 1832555120052666368 |
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| author | Tao Yu Young-Su Yi Yanyan Yang Jueun Oh Deok Jeong Jae Youl Cho |
| author_facet | Tao Yu Young-Su Yi Yanyan Yang Jueun Oh Deok Jeong Jae Youl Cho |
| author_sort | Tao Yu |
| collection | DOAJ |
| description | Inflammation is a complex biological response of tissues to harmful stimuli such as pathogens, cell damage, or irritants. Inflammation is considered to be a major cause of most chronic diseases, especially in more than 100 types of inflammatory diseases which include Alzheimer's disease, rheumatoid arthritis, asthma, atherosclerosis, Crohn's disease, colitis, dermatitis, hepatitis, and Parkinson's disease. Recently, an increasing number of studies have focused on inflammatory diseases. TBK1 is a serine/threonine-protein kinase which regulates antiviral defense, host-virus interaction, and immunity. It is ubiquitously expressed in mouse stomach, colon, thymus, and liver. Interestingly, high levels of active TBK1 have also been found to be associated with inflammatory diseases, indicating that TBK1 is closely related to inflammatory responses. Even though relatively few studies have addressed the functional roles of TBK1 relating to inflammation, this paper discusses some recent findings that support the critical role of TBK1 in inflammatory diseases and underlie the necessity of trials to develop useful remedies or therapeutics that target TBK1 for the treatment of inflammatory diseases. |
| format | Article |
| id | doaj-art-94b1bcb279444dfba4acda621e7600ee |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-94b1bcb279444dfba4acda621e7600ee2025-02-03T05:49:36ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/979105979105The Pivotal Role of TBK1 in Inflammatory Responses Mediated by MacrophagesTao Yu0Young-Su Yi1Yanyan Yang2Jueun Oh3Deok Jeong4Jae Youl Cho5Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Republic of KoreaDepartment of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Republic of KoreaDepartment of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Republic of KoreaDepartment of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Republic of KoreaDepartment of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Republic of KoreaDepartment of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Republic of KoreaInflammation is a complex biological response of tissues to harmful stimuli such as pathogens, cell damage, or irritants. Inflammation is considered to be a major cause of most chronic diseases, especially in more than 100 types of inflammatory diseases which include Alzheimer's disease, rheumatoid arthritis, asthma, atherosclerosis, Crohn's disease, colitis, dermatitis, hepatitis, and Parkinson's disease. Recently, an increasing number of studies have focused on inflammatory diseases. TBK1 is a serine/threonine-protein kinase which regulates antiviral defense, host-virus interaction, and immunity. It is ubiquitously expressed in mouse stomach, colon, thymus, and liver. Interestingly, high levels of active TBK1 have also been found to be associated with inflammatory diseases, indicating that TBK1 is closely related to inflammatory responses. Even though relatively few studies have addressed the functional roles of TBK1 relating to inflammation, this paper discusses some recent findings that support the critical role of TBK1 in inflammatory diseases and underlie the necessity of trials to develop useful remedies or therapeutics that target TBK1 for the treatment of inflammatory diseases.http://dx.doi.org/10.1155/2012/979105 |
| spellingShingle | Tao Yu Young-Su Yi Yanyan Yang Jueun Oh Deok Jeong Jae Youl Cho The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages Mediators of Inflammation |
| title | The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages |
| title_full | The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages |
| title_fullStr | The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages |
| title_full_unstemmed | The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages |
| title_short | The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages |
| title_sort | pivotal role of tbk1 in inflammatory responses mediated by macrophages |
| url | http://dx.doi.org/10.1155/2012/979105 |
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