Metformin in patients with ischemic heart disease and type 2 diabetes mellitus: mechanism of action and clinical efficiency
Diabetes mellitus is one of the leading causes of death in modern society, primarily due to its cardiovascular complications. This factor drives search for novel pharmacologic agents to affect not only glycemic levels, but also the cardiovascular prognosis in diabetic patients with ischemic heart di...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2013-03-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/3590 |
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| author | Ekaterina Nikodimovna Kravchuk M M Galagudza |
| author_facet | Ekaterina Nikodimovna Kravchuk M M Galagudza |
| author_sort | Ekaterina Nikodimovna Kravchuk |
| collection | DOAJ |
| description | Diabetes mellitus is one of the leading causes of death in modern society, primarily due to its cardiovascular complications. This factor drives search for novel pharmacologic agents to affect not only glycemic levels, but also the cardiovascular prognosis in diabetic patients with ischemic heart disease. Recent studies demonstrate that aside from basic blood glucose lowering action, metformin shows beneficial influence on blood rheology and vascular tone, hemostasis, oxidative stress, lipid spectrum and delivers and an ant-ischemic effect. Here we review clinical and experimental evidence on cardio- and vasoprotective effects of metformin, highlighting their molecular mechanisms. |
| format | Article |
| id | doaj-art-94aae411be3e471ab0f044046e06eeb0 |
| institution | OA Journals |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2013-03-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-94aae411be3e471ab0f044046e06eeb02025-08-20T01:57:09ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782013-03-0116151410.14341/2072-0351-35903560Metformin in patients with ischemic heart disease and type 2 diabetes mellitus: mechanism of action and clinical efficiencyEkaterina Nikodimovna Kravchuk0M M Galagudza1V.A. Almazov Federal Heart, Blood and Endocrinology Centre, St-Petersburg, Russian FederationV.A. Almazov Federal Heart, Blood and Endocrinology Centre, St-Petersburg, Russian Federation; I.P. Pavlov State Medical University, St-Petersburg, Russian FederationDiabetes mellitus is one of the leading causes of death in modern society, primarily due to its cardiovascular complications. This factor drives search for novel pharmacologic agents to affect not only glycemic levels, but also the cardiovascular prognosis in diabetic patients with ischemic heart disease. Recent studies demonstrate that aside from basic blood glucose lowering action, metformin shows beneficial influence on blood rheology and vascular tone, hemostasis, oxidative stress, lipid spectrum and delivers and an ant-ischemic effect. Here we review clinical and experimental evidence on cardio- and vasoprotective effects of metformin, highlighting their molecular mechanisms.https://www.dia-endojournals.ru/jour/article/view/3590diabetes mellitus type 2metforminamp-activated protein kinaseischemic heart disease |
| spellingShingle | Ekaterina Nikodimovna Kravchuk M M Galagudza Metformin in patients with ischemic heart disease and type 2 diabetes mellitus: mechanism of action and clinical efficiency Сахарный диабет diabetes mellitus type 2 metformin amp-activated protein kinase ischemic heart disease |
| title | Metformin in patients with ischemic heart disease and type 2 diabetes mellitus: mechanism of action and clinical efficiency |
| title_full | Metformin in patients with ischemic heart disease and type 2 diabetes mellitus: mechanism of action and clinical efficiency |
| title_fullStr | Metformin in patients with ischemic heart disease and type 2 diabetes mellitus: mechanism of action and clinical efficiency |
| title_full_unstemmed | Metformin in patients with ischemic heart disease and type 2 diabetes mellitus: mechanism of action and clinical efficiency |
| title_short | Metformin in patients with ischemic heart disease and type 2 diabetes mellitus: mechanism of action and clinical efficiency |
| title_sort | metformin in patients with ischemic heart disease and type 2 diabetes mellitus mechanism of action and clinical efficiency |
| topic | diabetes mellitus type 2 metformin amp-activated protein kinase ischemic heart disease |
| url | https://www.dia-endojournals.ru/jour/article/view/3590 |
| work_keys_str_mv | AT ekaterinanikodimovnakravchuk metformininpatientswithischemicheartdiseaseandtype2diabetesmellitusmechanismofactionandclinicalefficiency AT mmgalagudza metformininpatientswithischemicheartdiseaseandtype2diabetesmellitusmechanismofactionandclinicalefficiency |