Gq-Coupled Receptors in Autoimmunity
Heterotrimeric G proteins can be divided into Gi, Gs, Gq/11, and G12/13 subfamilies according to their α subunits. The main function of G proteins is transducing signals from G protein coupled receptors (GPCRs), a family of seven transmembrane receptors. In recent years, studies have demonstrated th...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/3969023 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850210313504292864 |
|---|---|
| author | Lu Zhang Guixiu Shi |
| author_facet | Lu Zhang Guixiu Shi |
| author_sort | Lu Zhang |
| collection | DOAJ |
| description | Heterotrimeric G proteins can be divided into Gi, Gs, Gq/11, and G12/13 subfamilies according to their α subunits. The main function of G proteins is transducing signals from G protein coupled receptors (GPCRs), a family of seven transmembrane receptors. In recent years, studies have demonstrated that GPCRs interact with Gq, a member of the Gq/11 subfamily of G proteins. This interaction facilitates the vital role of this family of proteins in immune regulation and autoimmunity, particularly for Gαq, which is considered the functional α subunit of Gq protein. Therefore, understanding the mechanisms through which Gq-coupled receptors control autoreactive lymphocytes is critical and may provide insights into the treatment of autoimmune disorders. In this review, we summarize recent advances in studies of the role of Gq-coupled receptors in autoimmunity, with a focus on their pathologic role and downstream signaling. |
| format | Article |
| id | doaj-art-94a98df74d8d4cd3afcb1475e7931744 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-94a98df74d8d4cd3afcb1475e79317442025-08-20T02:09:48ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/39690233969023Gq-Coupled Receptors in AutoimmunityLu Zhang0Guixiu Shi1Department of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, ChinaDepartment of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen 361003, ChinaHeterotrimeric G proteins can be divided into Gi, Gs, Gq/11, and G12/13 subfamilies according to their α subunits. The main function of G proteins is transducing signals from G protein coupled receptors (GPCRs), a family of seven transmembrane receptors. In recent years, studies have demonstrated that GPCRs interact with Gq, a member of the Gq/11 subfamily of G proteins. This interaction facilitates the vital role of this family of proteins in immune regulation and autoimmunity, particularly for Gαq, which is considered the functional α subunit of Gq protein. Therefore, understanding the mechanisms through which Gq-coupled receptors control autoreactive lymphocytes is critical and may provide insights into the treatment of autoimmune disorders. In this review, we summarize recent advances in studies of the role of Gq-coupled receptors in autoimmunity, with a focus on their pathologic role and downstream signaling.http://dx.doi.org/10.1155/2016/3969023 |
| spellingShingle | Lu Zhang Guixiu Shi Gq-Coupled Receptors in Autoimmunity Journal of Immunology Research |
| title | Gq-Coupled Receptors in Autoimmunity |
| title_full | Gq-Coupled Receptors in Autoimmunity |
| title_fullStr | Gq-Coupled Receptors in Autoimmunity |
| title_full_unstemmed | Gq-Coupled Receptors in Autoimmunity |
| title_short | Gq-Coupled Receptors in Autoimmunity |
| title_sort | gq coupled receptors in autoimmunity |
| url | http://dx.doi.org/10.1155/2016/3969023 |
| work_keys_str_mv | AT luzhang gqcoupledreceptorsinautoimmunity AT guixiushi gqcoupledreceptorsinautoimmunity |