Distinct infectivity and neutralization antibody responses in the highly homologous AAV Go.1 and AAV5

Distinct infectivity and neutralization antibody responses in the highly homologous AAV Go.1 and AAV5

IntroductionGoat-derived adeno-associated virus (AAV) vectors, such as AAV Go.1, represent a novel platform for gene therapy due to their unique origin and potential advantages in transduction efficiency and immune evasion. However, their therapeutic potential and biological properties remain undere...

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Bibliographic Details
Main Authors: Mei Li, Haixiao Ma, Yang Wu, Yunling Gao, Jie Wang, Hanbing Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Medicine
Subjects:
gene therapy
rAAV Go.1
cell transfection
neutralizing antibody
packaging efficiency
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1554449/full
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