Mitochondria at the crossroads: Quality control mechanisms in neuronal senescence and neurodegeneration
Mitochondria play a central role in essential cellular processes, including energy metabolism, biosynthesis of metabolic substances, calcium ion storage, and regulation of cell death. Maintaining mitochondrial quality control is critical for preserving mitochondrial health and ensuring cellular func...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Neurobiology of Disease |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996125000786 |
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| author | Yifei Zheng Jiahui Yang Xuanyao Li Linjie Qi Zhuo Zheng Jiming Kong Guohui Zhang Ying Guo |
| author_facet | Yifei Zheng Jiahui Yang Xuanyao Li Linjie Qi Zhuo Zheng Jiming Kong Guohui Zhang Ying Guo |
| author_sort | Yifei Zheng |
| collection | DOAJ |
| description | Mitochondria play a central role in essential cellular processes, including energy metabolism, biosynthesis of metabolic substances, calcium ion storage, and regulation of cell death. Maintaining mitochondrial quality control is critical for preserving mitochondrial health and ensuring cellular function. Given their high energy demands, neurons depend on effective mitochondrial quality control to sustain their health and functionality. Neuronal senescence, characterized by a progressive decline in structural integrity and function, is a hallmark of neurodegenerative diseases. In senescent neurons, abnormal mitochondrial morphology, functional impairments, increased reactive oxygen species production and disrupted quality control mechanisms are frequently observed. Understanding the pathological changes in neuronal structure, exploring the intricate relationship between mitochondrial quality control and neuronal health, and leveraging mitochondrial quality control interventions provide a promising foundation for addressing age-related neurodegenerative diseases. This review highlights key mitochondrial quality control, including biogenesis, dynamics, the ubiquitin-proteasome system, autophagy pathways, mitochondria-derived vesicles, and inter-organelle communication, while discussing their roles in neuronal senescence and potential therapeutic strategies. These insights may pave the way for innovative treatments to mitigate neurodegenerative disorders. |
| format | Article |
| id | doaj-art-94a7e6b8fd924dfaabe6a784132bd273 |
| institution | OA Journals |
| issn | 1095-953X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj-art-94a7e6b8fd924dfaabe6a784132bd2732025-08-20T02:16:27ZengElsevierNeurobiology of Disease1095-953X2025-05-0120810686210.1016/j.nbd.2025.106862Mitochondria at the crossroads: Quality control mechanisms in neuronal senescence and neurodegenerationYifei Zheng0Jiahui Yang1Xuanyao Li2Linjie Qi3Zhuo Zheng4Jiming Kong5Guohui Zhang6Ying Guo7Basic Medical College, Hebei North University, Zhangjiakou, Hebei, ChinaBasic Medical College, Hebei North University, Zhangjiakou, Hebei, ChinaBasic Medical College, Hebei North University, Zhangjiakou, Hebei, ChinaBasic Medical College, Hebei North University, Zhangjiakou, Hebei, ChinaBasic Medical College, Hebei North University, Zhangjiakou, Hebei, ChinaDepartment of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, Canada; Corresponding authors.Department of Forensic Medicine, Hebei North University, Zhangjiakou, Hebei, China; Corresponding authors.Department of Forensic Medicine, Hebei North University, Zhangjiakou, Hebei, China; Department of Pathology, Hebei North University, Zhangjiakou, Hebei, China; Hebei Key Laboratory of Neuropharmacology, Hebei North University, Zhangjiakou, Hebei, China; Corresponding author at: Department of Pathology, Hebei North University, Zhangjiakou, Hebei, China.Mitochondria play a central role in essential cellular processes, including energy metabolism, biosynthesis of metabolic substances, calcium ion storage, and regulation of cell death. Maintaining mitochondrial quality control is critical for preserving mitochondrial health and ensuring cellular function. Given their high energy demands, neurons depend on effective mitochondrial quality control to sustain their health and functionality. Neuronal senescence, characterized by a progressive decline in structural integrity and function, is a hallmark of neurodegenerative diseases. In senescent neurons, abnormal mitochondrial morphology, functional impairments, increased reactive oxygen species production and disrupted quality control mechanisms are frequently observed. Understanding the pathological changes in neuronal structure, exploring the intricate relationship between mitochondrial quality control and neuronal health, and leveraging mitochondrial quality control interventions provide a promising foundation for addressing age-related neurodegenerative diseases. This review highlights key mitochondrial quality control, including biogenesis, dynamics, the ubiquitin-proteasome system, autophagy pathways, mitochondria-derived vesicles, and inter-organelle communication, while discussing their roles in neuronal senescence and potential therapeutic strategies. These insights may pave the way for innovative treatments to mitigate neurodegenerative disorders.http://www.sciencedirect.com/science/article/pii/S0969996125000786Mitochondrial quality controlSenescenceNeuronTherapeutic strategiesNeurodegenerative diseases |
| spellingShingle | Yifei Zheng Jiahui Yang Xuanyao Li Linjie Qi Zhuo Zheng Jiming Kong Guohui Zhang Ying Guo Mitochondria at the crossroads: Quality control mechanisms in neuronal senescence and neurodegeneration Neurobiology of Disease Mitochondrial quality control Senescence Neuron Therapeutic strategies Neurodegenerative diseases |
| title | Mitochondria at the crossroads: Quality control mechanisms in neuronal senescence and neurodegeneration |
| title_full | Mitochondria at the crossroads: Quality control mechanisms in neuronal senescence and neurodegeneration |
| title_fullStr | Mitochondria at the crossroads: Quality control mechanisms in neuronal senescence and neurodegeneration |
| title_full_unstemmed | Mitochondria at the crossroads: Quality control mechanisms in neuronal senescence and neurodegeneration |
| title_short | Mitochondria at the crossroads: Quality control mechanisms in neuronal senescence and neurodegeneration |
| title_sort | mitochondria at the crossroads quality control mechanisms in neuronal senescence and neurodegeneration |
| topic | Mitochondrial quality control Senescence Neuron Therapeutic strategies Neurodegenerative diseases |
| url | http://www.sciencedirect.com/science/article/pii/S0969996125000786 |
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