Role of Chest Radiography in Diagnosing Pulmonary Tuberculosis, Does Every Suspected Case Needs GeneXpert MTB; A Cross-Sectional Study
Background: Pulmonary tuberculosis (TB) triggers a common infection globally. Chest X-ray (CXR) plays a role in diagnosis of pulmonary TB and has typical findings. CXR is cost effective modality and can help to reduce the burden on health system if smear, culture, or rapid molecular tests are only...
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Health Research Institute (HRI), National Institute of Health (NIH)
2025-02-01
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| Series: | Pakistan Journal of Medical Research |
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| Online Access: | https://www.pjmr.org.pk/index.php/pjmr/article/view/763 |
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| author | Mujahid Raza Saleh Khurshied Altaf Hussain Nawal Khurshid Ali Khurshid |
| author_facet | Mujahid Raza Saleh Khurshied Altaf Hussain Nawal Khurshid Ali Khurshid |
| author_sort | Mujahid Raza |
| collection | DOAJ |
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Background: Pulmonary tuberculosis (TB) triggers a common infection globally. Chest X-ray (CXR) plays a role in diagnosis of pulmonary TB and has typical findings. CXR is cost effective modality and can help to reduce the burden on health system if smear, culture, or rapid molecular tests are only done in patients where CXR shows suspicion of pulmonary TB.
Objective: To evaluate the diagnostic role of CXR versus standard GeneXpert MTB among adults suspecting pulmonary tuberculosis.
Study type, settings & duration: This cross sectional study carried out at Department of Radiology, Pakistan Institute of Medical sciences (PIMS), Islamabad from November 2023 to January 2024.
Methodology: CXR of symptomatic patients with and without findings consistent with Pulmonary TB were compared with GeneXpert MTB results for association between the results of two.
Results: The mean age of the participants was 38±6.34. About 128 (75.74%) were male 41 (24.26%) were female. Out of total 169 CXR 47 (27.81%) had findings consistent with pulmonary TB of which 31 (65.96%) were detected as confirmed TB cases on GeneXpert. Those 122 (72.18%) which were not suspicious of pulmonary TB on CXR when tested for GeneXpert MTB showed positive results in 21 (12.42%) cases (p ≤0.0001). The Positive predictive value, Negative predictive value, sensitivity, and specificity were calculated to be 66.0%, 82.8%, 59.6% and 86.3% respectively.
Conclusion: CXR plays a vital role in the diagnosing adults with suspected active pulmonary tuberculosis by comparing with GeneXpert MTB in symptomatic patients.
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| format | Article |
| id | doaj-art-94a33c8135a04efa847bf74df1c34fba |
| institution | Kabale University |
| issn | 0030-9842 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Health Research Institute (HRI), National Institute of Health (NIH) |
| record_format | Article |
| series | Pakistan Journal of Medical Research |
| spelling | doaj-art-94a33c8135a04efa847bf74df1c34fba2025-02-12T01:06:25ZengHealth Research Institute (HRI), National Institute of Health (NIH)Pakistan Journal of Medical Research0030-98422025-02-01634Role of Chest Radiography in Diagnosing Pulmonary Tuberculosis, Does Every Suspected Case Needs GeneXpert MTB; A Cross-Sectional StudyMujahid Raza0Saleh Khurshied1Altaf Hussain2Nawal Khurshid3Ali Khurshid4Department of Radiology, Pakistan Institute of Medical sciences (PIMS), Islamabad. Department of ENT, Pakistan Institute of Medical sciences (PIMS), Islamabad.Department of ENT, Pakistan Institute of Medical Sciences (PIMS), Islamabad.Pakistan Institute of Medical sciences, PIMS Islamabad Pakistan Institute of Medical sciences (PIMS), Islamabad. Background: Pulmonary tuberculosis (TB) triggers a common infection globally. Chest X-ray (CXR) plays a role in diagnosis of pulmonary TB and has typical findings. CXR is cost effective modality and can help to reduce the burden on health system if smear, culture, or rapid molecular tests are only done in patients where CXR shows suspicion of pulmonary TB. Objective: To evaluate the diagnostic role of CXR versus standard GeneXpert MTB among adults suspecting pulmonary tuberculosis. Study type, settings & duration: This cross sectional study carried out at Department of Radiology, Pakistan Institute of Medical sciences (PIMS), Islamabad from November 2023 to January 2024. Methodology: CXR of symptomatic patients with and without findings consistent with Pulmonary TB were compared with GeneXpert MTB results for association between the results of two. Results: The mean age of the participants was 38±6.34. About 128 (75.74%) were male 41 (24.26%) were female. Out of total 169 CXR 47 (27.81%) had findings consistent with pulmonary TB of which 31 (65.96%) were detected as confirmed TB cases on GeneXpert. Those 122 (72.18%) which were not suspicious of pulmonary TB on CXR when tested for GeneXpert MTB showed positive results in 21 (12.42%) cases (p ≤0.0001). The Positive predictive value, Negative predictive value, sensitivity, and specificity were calculated to be 66.0%, 82.8%, 59.6% and 86.3% respectively. Conclusion: CXR plays a vital role in the diagnosing adults with suspected active pulmonary tuberculosis by comparing with GeneXpert MTB in symptomatic patients. https://www.pjmr.org.pk/index.php/pjmr/article/view/763Chest X-rayTuberculosisDiagnosisGeneXpert |
| spellingShingle | Mujahid Raza Saleh Khurshied Altaf Hussain Nawal Khurshid Ali Khurshid Role of Chest Radiography in Diagnosing Pulmonary Tuberculosis, Does Every Suspected Case Needs GeneXpert MTB; A Cross-Sectional Study Pakistan Journal of Medical Research Chest X-ray Tuberculosis Diagnosis GeneXpert |
| title | Role of Chest Radiography in Diagnosing Pulmonary Tuberculosis, Does Every Suspected Case Needs GeneXpert MTB; A Cross-Sectional Study |
| title_full | Role of Chest Radiography in Diagnosing Pulmonary Tuberculosis, Does Every Suspected Case Needs GeneXpert MTB; A Cross-Sectional Study |
| title_fullStr | Role of Chest Radiography in Diagnosing Pulmonary Tuberculosis, Does Every Suspected Case Needs GeneXpert MTB; A Cross-Sectional Study |
| title_full_unstemmed | Role of Chest Radiography in Diagnosing Pulmonary Tuberculosis, Does Every Suspected Case Needs GeneXpert MTB; A Cross-Sectional Study |
| title_short | Role of Chest Radiography in Diagnosing Pulmonary Tuberculosis, Does Every Suspected Case Needs GeneXpert MTB; A Cross-Sectional Study |
| title_sort | role of chest radiography in diagnosing pulmonary tuberculosis does every suspected case needs genexpert mtb a cross sectional study |
| topic | Chest X-ray Tuberculosis Diagnosis GeneXpert |
| url | https://www.pjmr.org.pk/index.php/pjmr/article/view/763 |
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