Formula with real food ingredients for tube feeding in children with neuromuscular disorders (NMDs): A case series
The aim of this case series was to evaluate the tolerability, safety, and efficacy of an enteral formula containing food-derived ingredients for pediatric patients with neuromuscular disorders (NMDs). Children (1–17 years) with (i) a formally diagnosed NMD and (ii) exclusive enteral nutrition were e...
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Elsevier
2025-06-01
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| Series: | Human Nutrition & Metabolism |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266614972500009X |
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| author | Valeria Dipasquale Rossella Morello Claudio Romano |
| author_facet | Valeria Dipasquale Rossella Morello Claudio Romano |
| author_sort | Valeria Dipasquale |
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| description | The aim of this case series was to evaluate the tolerability, safety, and efficacy of an enteral formula containing food-derived ingredients for pediatric patients with neuromuscular disorders (NMDs). Children (1–17 years) with (i) a formally diagnosed NMD and (ii) exclusive enteral nutrition were enrolled. Patients received a nutritionally complete 1.2 kcal/mL enteral formula containing food-derived ingredients (peas, green beans, peaches, carrots, and chicken). Weight, body mass index (BMI), mid-upper-arm-circumference (MUAC) standard deviation (SD), and symptoms were assessed at the baseline (formula start; visit 1) and at 6 months (visit 2). Five NMD children with spinal muscular atrophy were included. Weight and BMI increased significantly after a mean of 2.5 months: weight −3.5 (V1) vs. −2.5 Z-score (V2) (p = 0.004) and BMI -3.8 (V1) vs. - 3 Z-score (V2) (p = 0.03). MUAC SD increased over the study period as well, even though the increase was not statistically significant (p = 0.231). All patients well tolerated the formula, and a relief from gastrointestinal symptoms was reported. The enteral formula containing food-derived ingredients may be a valid option in tube feeding management for children with NMDs. A small sample size and retrospective design limit the generalizability of findings. Further data (e.g., larger sample size, longer follow-up period, or different NMD subtypes) are needed. |
| format | Article |
| id | doaj-art-94a10e63a15f4ac2a081d2a0237adffa |
| institution | DOAJ |
| issn | 2666-1497 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
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| series | Human Nutrition & Metabolism |
| spelling | doaj-art-94a10e63a15f4ac2a081d2a0237adffa2025-08-20T02:55:20ZengElsevierHuman Nutrition & Metabolism2666-14972025-06-014020030610.1016/j.hnm.2025.200306Formula with real food ingredients for tube feeding in children with neuromuscular disorders (NMDs): A case seriesValeria Dipasquale0Rossella Morello1Claudio Romano2Unit of Pediatric Gastroenterology and Cystic Fibrosis, Department of Human Pathology in Adulthood and Childhood “G. Barresi”, University Hospital “G. Martino”, Messina, ItalyUnit of Pediatric Gastroenterology and Cystic Fibrosis, Department of Human Pathology in Adulthood and Childhood “G. Barresi”, University Hospital “G. Martino”, Messina, ItalyCorresponding author. Unit of Pediatric Gastroenterology and Cystic Fibrosis, Department of Human Pathology in Adulthood and Childhood “G. Barresi”, University Hospital “G. Martino”, Via Consolare Valeria 1, 98125, Messina, Italy.; Unit of Pediatric Gastroenterology and Cystic Fibrosis, Department of Human Pathology in Adulthood and Childhood “G. Barresi”, University Hospital “G. Martino”, Messina, ItalyThe aim of this case series was to evaluate the tolerability, safety, and efficacy of an enteral formula containing food-derived ingredients for pediatric patients with neuromuscular disorders (NMDs). Children (1–17 years) with (i) a formally diagnosed NMD and (ii) exclusive enteral nutrition were enrolled. Patients received a nutritionally complete 1.2 kcal/mL enteral formula containing food-derived ingredients (peas, green beans, peaches, carrots, and chicken). Weight, body mass index (BMI), mid-upper-arm-circumference (MUAC) standard deviation (SD), and symptoms were assessed at the baseline (formula start; visit 1) and at 6 months (visit 2). Five NMD children with spinal muscular atrophy were included. Weight and BMI increased significantly after a mean of 2.5 months: weight −3.5 (V1) vs. −2.5 Z-score (V2) (p = 0.004) and BMI -3.8 (V1) vs. - 3 Z-score (V2) (p = 0.03). MUAC SD increased over the study period as well, even though the increase was not statistically significant (p = 0.231). All patients well tolerated the formula, and a relief from gastrointestinal symptoms was reported. The enteral formula containing food-derived ingredients may be a valid option in tube feeding management for children with NMDs. A small sample size and retrospective design limit the generalizability of findings. Further data (e.g., larger sample size, longer follow-up period, or different NMD subtypes) are needed.http://www.sciencedirect.com/science/article/pii/S266614972500009XCase reportNeuromuscular diseasesTube feedingChild |
| spellingShingle | Valeria Dipasquale Rossella Morello Claudio Romano Formula with real food ingredients for tube feeding in children with neuromuscular disorders (NMDs): A case series Human Nutrition & Metabolism Case report Neuromuscular diseases Tube feeding Child |
| title | Formula with real food ingredients for tube feeding in children with neuromuscular disorders (NMDs): A case series |
| title_full | Formula with real food ingredients for tube feeding in children with neuromuscular disorders (NMDs): A case series |
| title_fullStr | Formula with real food ingredients for tube feeding in children with neuromuscular disorders (NMDs): A case series |
| title_full_unstemmed | Formula with real food ingredients for tube feeding in children with neuromuscular disorders (NMDs): A case series |
| title_short | Formula with real food ingredients for tube feeding in children with neuromuscular disorders (NMDs): A case series |
| title_sort | formula with real food ingredients for tube feeding in children with neuromuscular disorders nmds a case series |
| topic | Case report Neuromuscular diseases Tube feeding Child |
| url | http://www.sciencedirect.com/science/article/pii/S266614972500009X |
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