Formula with real food ingredients for tube feeding in children with neuromuscular disorders (NMDs): A case series
The aim of this case series was to evaluate the tolerability, safety, and efficacy of an enteral formula containing food-derived ingredients for pediatric patients with neuromuscular disorders (NMDs). Children (1–17 years) with (i) a formally diagnosed NMD and (ii) exclusive enteral nutrition were e...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
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| Series: | Human Nutrition & Metabolism |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266614972500009X |
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| Summary: | The aim of this case series was to evaluate the tolerability, safety, and efficacy of an enteral formula containing food-derived ingredients for pediatric patients with neuromuscular disorders (NMDs). Children (1–17 years) with (i) a formally diagnosed NMD and (ii) exclusive enteral nutrition were enrolled. Patients received a nutritionally complete 1.2 kcal/mL enteral formula containing food-derived ingredients (peas, green beans, peaches, carrots, and chicken). Weight, body mass index (BMI), mid-upper-arm-circumference (MUAC) standard deviation (SD), and symptoms were assessed at the baseline (formula start; visit 1) and at 6 months (visit 2). Five NMD children with spinal muscular atrophy were included. Weight and BMI increased significantly after a mean of 2.5 months: weight −3.5 (V1) vs. −2.5 Z-score (V2) (p = 0.004) and BMI -3.8 (V1) vs. - 3 Z-score (V2) (p = 0.03). MUAC SD increased over the study period as well, even though the increase was not statistically significant (p = 0.231). All patients well tolerated the formula, and a relief from gastrointestinal symptoms was reported. The enteral formula containing food-derived ingredients may be a valid option in tube feeding management for children with NMDs. A small sample size and retrospective design limit the generalizability of findings. Further data (e.g., larger sample size, longer follow-up period, or different NMD subtypes) are needed. |
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| ISSN: | 2666-1497 |