Enabling Targeted Drug Delivery for Treatment of Ulcerative Colitis with Mucosal‐Adhesive Photoreactive Hydrogel
Abstract Ulcerative colitis (UC) is a chronic inflammatory bowel disease. UC treatments are limited by significant adverse effects associated with non‐specific drug delivery, such as systematic inhibition of the host immune system. Endoscopic delivery of a synthetic hydrogel material with biocompati...
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| Format: | Article |
| Language: | English |
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Wiley
2025-03-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202404836 |
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| author | Wen Wu Jian Zhang Xiao Qu Ting Chen Jinming Li Yongzhi Yang Lifeng Chen Alex Hoover Fanying Guo Cheng Kong Bingkun Bao Qiuning Lin Mengxin Zhou Linyong Zhu Xiaoyang Wu Yanlei Ma |
| author_facet | Wen Wu Jian Zhang Xiao Qu Ting Chen Jinming Li Yongzhi Yang Lifeng Chen Alex Hoover Fanying Guo Cheng Kong Bingkun Bao Qiuning Lin Mengxin Zhou Linyong Zhu Xiaoyang Wu Yanlei Ma |
| author_sort | Wen Wu |
| collection | DOAJ |
| description | Abstract Ulcerative colitis (UC) is a chronic inflammatory bowel disease. UC treatments are limited by significant adverse effects associated with non‐specific drug delivery, such as systematic inhibition of the host immune system. Endoscopic delivery of a synthetic hydrogel material with biocompatible gelation that can efficiently cover irregular tissue surfaces provides an effective approach for targeted drug delivery at the gastrointestinal (GI) tract. An ideal integration of synthetic material with intestinal epithelium entails an integrated and preferable chemically bonded interface between the hydrogel and mucosal surface. In this study, a photo‐triggered coupling reaction is leveraged as the crosslinking platform to develop a mucosal‐adhesive hydrogel, which is compatible with endoscope‐directed drug delivery for UC treatment. The results demonstrated superior spatiotemporal specificity and drug pharmacokinetics with this delivery system in vivo. Delivery of different drugs with the hydrogel leads to greatly enhanced therapeutic efficacy and significantly reduced systemic drug exposure with rat colitis models. The study presents a strategy for targeted and persistent drug delivery for UC treatment. |
| format | Article |
| id | doaj-art-949d9c5fe8a44e72ac0c1d555ef3682d |
| institution | DOAJ |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-949d9c5fe8a44e72ac0c1d555ef3682d2025-08-20T02:49:46ZengWileyAdvanced Science2198-38442025-03-011212n/an/a10.1002/advs.202404836Enabling Targeted Drug Delivery for Treatment of Ulcerative Colitis with Mucosal‐Adhesive Photoreactive HydrogelWen Wu0Jian Zhang1Xiao Qu2Ting Chen3Jinming Li4Yongzhi Yang5Lifeng Chen6Alex Hoover7Fanying Guo8Cheng Kong9Bingkun Bao10Qiuning Lin11Mengxin Zhou12Linyong Zhu13Xiaoyang Wu14Yanlei Ma15Department of Colorectal Surgery Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical College Fudan University No. 270 Dongan Road Shanghai 200032 ChinaBen May Department for Cancer Research University of Chicago GCIS W408B, 929 E 57th Street Chicago IL 60637 USADepartment of Endoscopy Fudan University Shanghai Cancer Center No. 270 Dongan Road Shanghai 200032 ChinaSchool of Biomedical Engineering Shanghai Jiao Tong University No. 800 Dongchuan Road Shanghai 200240 ChinaDepartment of Colorectal Surgery Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical College Fudan University No. 270 Dongan Road Shanghai 200032 ChinaDepartment of Colorectal Surgery Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical College Fudan University No. 270 Dongan Road Shanghai 200032 ChinaBen May Department for Cancer Research University of Chicago GCIS W408B, 929 E 57th Street Chicago IL 60637 USABen May Department for Cancer Research University of Chicago GCIS W408B, 929 E 57th Street Chicago IL 60637 USADepartment of Colorectal Surgery Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical College Fudan University No. 270 Dongan Road Shanghai 200032 ChinaDepartment of Colorectal Surgery Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical College Fudan University No. 270 Dongan Road Shanghai 200032 ChinaSchool of Biomedical Engineering Shanghai Jiao Tong University No. 800 Dongchuan Road Shanghai 200240 ChinaSchool of Biomedical Engineering Shanghai Jiao Tong University No. 800 Dongchuan Road Shanghai 200240 ChinaSchool of Chemistry and Molecular Engineering East China University of Science and Technology No.130 Meilong Road Shanghai 200237 ChinaSchool of Biomedical Engineering Shanghai Jiao Tong University No. 800 Dongchuan Road Shanghai 200240 ChinaBen May Department for Cancer Research University of Chicago GCIS W408B, 929 E 57th Street Chicago IL 60637 USADepartment of Colorectal Surgery Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical College Fudan University No. 270 Dongan Road Shanghai 200032 ChinaAbstract Ulcerative colitis (UC) is a chronic inflammatory bowel disease. UC treatments are limited by significant adverse effects associated with non‐specific drug delivery, such as systematic inhibition of the host immune system. Endoscopic delivery of a synthetic hydrogel material with biocompatible gelation that can efficiently cover irregular tissue surfaces provides an effective approach for targeted drug delivery at the gastrointestinal (GI) tract. An ideal integration of synthetic material with intestinal epithelium entails an integrated and preferable chemically bonded interface between the hydrogel and mucosal surface. In this study, a photo‐triggered coupling reaction is leveraged as the crosslinking platform to develop a mucosal‐adhesive hydrogel, which is compatible with endoscope‐directed drug delivery for UC treatment. The results demonstrated superior spatiotemporal specificity and drug pharmacokinetics with this delivery system in vivo. Delivery of different drugs with the hydrogel leads to greatly enhanced therapeutic efficacy and significantly reduced systemic drug exposure with rat colitis models. The study presents a strategy for targeted and persistent drug delivery for UC treatment.https://doi.org/10.1002/advs.202404836endoscopic drug deliveryphotoreactive hydrogelulcerative colitis |
| spellingShingle | Wen Wu Jian Zhang Xiao Qu Ting Chen Jinming Li Yongzhi Yang Lifeng Chen Alex Hoover Fanying Guo Cheng Kong Bingkun Bao Qiuning Lin Mengxin Zhou Linyong Zhu Xiaoyang Wu Yanlei Ma Enabling Targeted Drug Delivery for Treatment of Ulcerative Colitis with Mucosal‐Adhesive Photoreactive Hydrogel Advanced Science endoscopic drug delivery photoreactive hydrogel ulcerative colitis |
| title | Enabling Targeted Drug Delivery for Treatment of Ulcerative Colitis with Mucosal‐Adhesive Photoreactive Hydrogel |
| title_full | Enabling Targeted Drug Delivery for Treatment of Ulcerative Colitis with Mucosal‐Adhesive Photoreactive Hydrogel |
| title_fullStr | Enabling Targeted Drug Delivery for Treatment of Ulcerative Colitis with Mucosal‐Adhesive Photoreactive Hydrogel |
| title_full_unstemmed | Enabling Targeted Drug Delivery for Treatment of Ulcerative Colitis with Mucosal‐Adhesive Photoreactive Hydrogel |
| title_short | Enabling Targeted Drug Delivery for Treatment of Ulcerative Colitis with Mucosal‐Adhesive Photoreactive Hydrogel |
| title_sort | enabling targeted drug delivery for treatment of ulcerative colitis with mucosal adhesive photoreactive hydrogel |
| topic | endoscopic drug delivery photoreactive hydrogel ulcerative colitis |
| url | https://doi.org/10.1002/advs.202404836 |
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