Whether exercises and testosterone replacement therapy support a treatment for cardiovascular and atherosclerotic patients with iliac artery stenosis and low total testosterone and high-density lipoprotein cholesterol after endovascular procedure?
Serum levels of testosterone (ST) and high-density lipoprotein (HDL) are generally associated with atherosclerosis in male patients over 50 years with critic iliac stenosis (TASC II A and B) and cardiovascular disease with significant changes in HDL and low-density lipoprotein (LDL). In addition to...
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Zaporizhzhia State Medical and Pharmaceutical University
2023-04-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/268513/271250 |
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| author | Sid Solaković Nina Solaković Anes Jogunčić Hajrudin Spahović Fedja Hajrulahović Mensur Vrcić Emir Solaković Amina Godinjak Iryna Skrypchenko Olena Dorofieieva Kseniia Yarymbash |
| author_facet | Sid Solaković Nina Solaković Anes Jogunčić Hajrudin Spahović Fedja Hajrulahović Mensur Vrcić Emir Solaković Amina Godinjak Iryna Skrypchenko Olena Dorofieieva Kseniia Yarymbash |
| author_sort | Sid Solaković |
| collection | DOAJ |
| description | Serum levels of testosterone (ST) and high-density lipoprotein (HDL) are generally associated with atherosclerosis in male patients over 50 years with critic iliac stenosis (TASC II A and B) and cardiovascular disease with significant changes in HDL and low-density lipoprotein (LDL). In addition to the standard therapy, combined medicamentous therapy and adequate model of exercise are also important factors as medicines can improve HDL levels and primary bypass and endovascular potency impacting positively on improvement of ST or it can be the following testosterone replacement therapy (TRT) comprising cardiovascular disease prevention and vascular treatment as adjunct therapy options after endovascular and vascular surgical procedures.
The aim of the study is to identify the association between HDL and ST after surgical and endovascular intervention on the iliac segment (TASCII A and B), as well as cardiovascular risk factors with modified medium activity (MET) <6 with short interval increase over >6 (MET), with total duration of 30–60 minutes. It also attempts to remodel a patient behavioral pattern, optimize ST levels and link them to outcomes and patency of vascular procedures on the iliac segment.
Materials and methods. 108 selected male patients with cardiovascular disease combined with metabolic syndrome and critical iliac artery stenosis (TASC II A and B) were examined during 2014–2018, 4 years after invasive and minimal invasive treatment (54 patients were treated with surgical Dacron reconstruction and 54 patients – with endovascular treatment on short segment of critical iliac artery stenosis (TASC II A and B).
Results. In the total population, no difference was observed in changes of constraint-induced movement therapy between the standard exercise group and the control one after 4 years from baseline. However, there was no significant interaction between the effect of exercise trainings and primary bypass potency within 4 years.
Conclusions. Primary effects of endovascular procedure and Dacron bypass revascularization raise the risk of elevated testosterone levels after 4 years of group training but does not provide adequate answers to questions as to whether higher levels of ST have any major influence on primary bypass potency preventing further progression of cardiovascular disease and general symptomatic and asymptomatic atherosclerosis. However, exercise and TRT can be potential adjunctive therapeutic options for a future supporting postsurgical and endovascular illiac treatment in cardiovascular patients with low testosterone levels.
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| format | Article |
| id | doaj-art-949bd5c952634ea8a1b399a1bfa115ad |
| institution | Kabale University |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-949bd5c952634ea8a1b399a1bfa115ad2025-08-20T03:37:27ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102023-04-0125210110810.14739/2310-1210.2023.2.268513Whether exercises and testosterone replacement therapy support a treatment for cardiovascular and atherosclerotic patients with iliac artery stenosis and low total testosterone and high-density lipoprotein cholesterol after endovascular procedure?Sid Solaković0https://orcid.org/0000-0001-6092-1985Nina Solaković1https://orcid.org/0000-0003-4350-0876Anes Jogunčić2https://orcid.org/0000-0001-6926-0079Hajrudin Spahović3https://orcid.org/0000-0003-4147-2082Fedja Hajrulahović4https://orcid.org/0000-0002-1268-2446Mensur Vrcić5https://orcid.org/0000-0002-8331-9062Emir Solaković6https://orcid.org/0000-0001-5893-3522Amina Godinjak7https://orcid.org/0000-0002-3697-8006Iryna Skrypchenko8https://orcid.org/0000-0001-5895-3099Olena Dorofieieva9https://orcid.org/0000-0003-2602-1873Kseniia Yarymbash10https://orcid.org/0000-0003-4694-291XDepartment for Vascular Surgery, Special Hospital Dr. Solakovic, Sarajevo, Bosnia and HerzegovinaDermatology Department, Special Hospital Dr. Solakovic, Bosnia and HerzegovinaSarajevo School of Science and Technology, Bosnia and HerzegovinSarajevo School of Science and Technology, Bosnia and HerzegovinaHealth Center, Sarajevo, Bosnia and HerzegovinaUniversity of Sarajevo, Bosnia and HerzegovinaSpecial Hospital Dr. Solakovic, Sarajevo, Bosnia and HerzegovinCardiovascular Surgery Clinic and Vascular Surgery Department, Clinical Center of the University in Sarajevo, Bosnia and HerzegovinaDnipropetrovsk State University of Internal Affairs, Dnipro, UkraineBogomolets National Medical University, Kyiv, UkraineBogomolets National Medical University, Kyiv, UkraineSerum levels of testosterone (ST) and high-density lipoprotein (HDL) are generally associated with atherosclerosis in male patients over 50 years with critic iliac stenosis (TASC II A and B) and cardiovascular disease with significant changes in HDL and low-density lipoprotein (LDL). In addition to the standard therapy, combined medicamentous therapy and adequate model of exercise are also important factors as medicines can improve HDL levels and primary bypass and endovascular potency impacting positively on improvement of ST or it can be the following testosterone replacement therapy (TRT) comprising cardiovascular disease prevention and vascular treatment as adjunct therapy options after endovascular and vascular surgical procedures. The aim of the study is to identify the association between HDL and ST after surgical and endovascular intervention on the iliac segment (TASCII A and B), as well as cardiovascular risk factors with modified medium activity (MET) <6 with short interval increase over >6 (MET), with total duration of 30–60 minutes. It also attempts to remodel a patient behavioral pattern, optimize ST levels and link them to outcomes and patency of vascular procedures on the iliac segment. Materials and methods. 108 selected male patients with cardiovascular disease combined with metabolic syndrome and critical iliac artery stenosis (TASC II A and B) were examined during 2014–2018, 4 years after invasive and minimal invasive treatment (54 patients were treated with surgical Dacron reconstruction and 54 patients – with endovascular treatment on short segment of critical iliac artery stenosis (TASC II A and B). Results. In the total population, no difference was observed in changes of constraint-induced movement therapy between the standard exercise group and the control one after 4 years from baseline. However, there was no significant interaction between the effect of exercise trainings and primary bypass potency within 4 years. Conclusions. Primary effects of endovascular procedure and Dacron bypass revascularization raise the risk of elevated testosterone levels after 4 years of group training but does not provide adequate answers to questions as to whether higher levels of ST have any major influence on primary bypass potency preventing further progression of cardiovascular disease and general symptomatic and asymptomatic atherosclerosis. However, exercise and TRT can be potential adjunctive therapeutic options for a future supporting postsurgical and endovascular illiac treatment in cardiovascular patients with low testosterone levels. http://zmj.zsmu.edu.ua/article/view/268513/271250exercisetestosterone replacement therapycritical iliac stenosis ii a and bserum testosterone |
| spellingShingle | Sid Solaković Nina Solaković Anes Jogunčić Hajrudin Spahović Fedja Hajrulahović Mensur Vrcić Emir Solaković Amina Godinjak Iryna Skrypchenko Olena Dorofieieva Kseniia Yarymbash Whether exercises and testosterone replacement therapy support a treatment for cardiovascular and atherosclerotic patients with iliac artery stenosis and low total testosterone and high-density lipoprotein cholesterol after endovascular procedure? Zaporožskij Medicinskij Žurnal exercise testosterone replacement therapy critical iliac stenosis ii a and b serum testosterone |
| title | Whether exercises and testosterone replacement therapy support a treatment for cardiovascular and atherosclerotic patients with iliac artery stenosis and low total testosterone and high-density lipoprotein cholesterol after endovascular procedure? |
| title_full | Whether exercises and testosterone replacement therapy support a treatment for cardiovascular and atherosclerotic patients with iliac artery stenosis and low total testosterone and high-density lipoprotein cholesterol after endovascular procedure? |
| title_fullStr | Whether exercises and testosterone replacement therapy support a treatment for cardiovascular and atherosclerotic patients with iliac artery stenosis and low total testosterone and high-density lipoprotein cholesterol after endovascular procedure? |
| title_full_unstemmed | Whether exercises and testosterone replacement therapy support a treatment for cardiovascular and atherosclerotic patients with iliac artery stenosis and low total testosterone and high-density lipoprotein cholesterol after endovascular procedure? |
| title_short | Whether exercises and testosterone replacement therapy support a treatment for cardiovascular and atherosclerotic patients with iliac artery stenosis and low total testosterone and high-density lipoprotein cholesterol after endovascular procedure? |
| title_sort | whether exercises and testosterone replacement therapy support a treatment for cardiovascular and atherosclerotic patients with iliac artery stenosis and low total testosterone and high density lipoprotein cholesterol after endovascular procedure |
| topic | exercise testosterone replacement therapy critical iliac stenosis ii a and b serum testosterone |
| url | http://zmj.zsmu.edu.ua/article/view/268513/271250 |
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