Cellular Senescence as a Target in Cancer Control
Somatic cells show a spontaneous decline in growth rate in continuous culture. This is not related to elapsed time but to an increasing number of population doublings, eventually terminating in a quiescent but viable state termed replicative senescence. These cells are commonly multinucleated and do...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.4061/2011/725365 |
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| _version_ | 1832568012736036864 |
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| author | Mar Vergel Juan J. Marin Purificacion Estevez Amancio Carnero |
| author_facet | Mar Vergel Juan J. Marin Purificacion Estevez Amancio Carnero |
| author_sort | Mar Vergel |
| collection | DOAJ |
| description | Somatic cells show a spontaneous decline in growth rate in continuous culture. This is not related to elapsed time but to an increasing number of population doublings, eventually terminating in a quiescent but viable state termed replicative senescence. These cells are commonly multinucleated and do not respond to mitogens or apoptotic stimuli. Cells displaying characteristics of senescent cells can also be observed in response to other stimuli, such as oncogenic stress, DNA damage, or cytotoxic drugs and have been reported to be found in vivo. Most tumors show unlimited replicative potential, leading to the hypothesis that cellular senescence is a natural antitumor program. Recent findings suggest that cellular senescence is a natural mechanism to prevent undesired oncogenic stress in somatic cells that has been lost in malignant tumors. Given that the ultimate goal of cancer research is to find the definitive cure for as many tumor types as possible, exploration of cellular senescence to drive towards antitumor therapies may decisively influence the outcome of new drugs. In the present paper, we will review the potential of cellular senescence to be used as target for anticancer therapy. |
| format | Article |
| id | doaj-art-949a711b969647f8b1f5d35349e3ae1a |
| institution | Kabale University |
| issn | 2090-2212 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-949a711b969647f8b1f5d35349e3ae1a2025-02-03T01:00:01ZengWileyJournal of Aging Research2090-22122011-01-01201110.4061/2011/725365725365Cellular Senescence as a Target in Cancer ControlMar Vergel0Juan J. Marin1Purificacion Estevez2Amancio Carnero3Instituto de Biomedicina de Sevilla, Hospital Universitario virgen del Rocio, 41013 Sevilla, SpainDepartment of Preventive Medicine and Public Heath, University of Seville, 41012 Seville, SpainInstituto de Biomedicina de Sevilla, Hospital Universitario virgen del Rocio, 41013 Sevilla, SpainInstituto de Biomedicina de Sevilla, Hospital Universitario virgen del Rocio, 41013 Sevilla, SpainSomatic cells show a spontaneous decline in growth rate in continuous culture. This is not related to elapsed time but to an increasing number of population doublings, eventually terminating in a quiescent but viable state termed replicative senescence. These cells are commonly multinucleated and do not respond to mitogens or apoptotic stimuli. Cells displaying characteristics of senescent cells can also be observed in response to other stimuli, such as oncogenic stress, DNA damage, or cytotoxic drugs and have been reported to be found in vivo. Most tumors show unlimited replicative potential, leading to the hypothesis that cellular senescence is a natural antitumor program. Recent findings suggest that cellular senescence is a natural mechanism to prevent undesired oncogenic stress in somatic cells that has been lost in malignant tumors. Given that the ultimate goal of cancer research is to find the definitive cure for as many tumor types as possible, exploration of cellular senescence to drive towards antitumor therapies may decisively influence the outcome of new drugs. In the present paper, we will review the potential of cellular senescence to be used as target for anticancer therapy.http://dx.doi.org/10.4061/2011/725365 |
| spellingShingle | Mar Vergel Juan J. Marin Purificacion Estevez Amancio Carnero Cellular Senescence as a Target in Cancer Control Journal of Aging Research |
| title | Cellular Senescence as a Target in Cancer Control |
| title_full | Cellular Senescence as a Target in Cancer Control |
| title_fullStr | Cellular Senescence as a Target in Cancer Control |
| title_full_unstemmed | Cellular Senescence as a Target in Cancer Control |
| title_short | Cellular Senescence as a Target in Cancer Control |
| title_sort | cellular senescence as a target in cancer control |
| url | http://dx.doi.org/10.4061/2011/725365 |
| work_keys_str_mv | AT marvergel cellularsenescenceasatargetincancercontrol AT juanjmarin cellularsenescenceasatargetincancercontrol AT purificacionestevez cellularsenescenceasatargetincancercontrol AT amanciocarnero cellularsenescenceasatargetincancercontrol |