(1 →3)- β -D-Glucan and endotoxin modulate immune response to inhaled allergen
Exposure to dust may involve co-exposure to agents which are allergens, together with those which are pro-inflamm atory. To study the effects of such a coexposure, the humoral and inflammatory responses were studied in guinea pigs inhaling the T-cell dependent antigen ovalbumin (OVA) and the inflamm...
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| Format: | Article |
| Language: | English |
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Wiley
1998-01-01
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| Series: | Mediators of Inflammation |
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| Online Access: | http://dx.doi.org/10.1080/09629359891252 |
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| author | R. Rylander P. G. Holt |
| author_facet | R. Rylander P. G. Holt |
| author_sort | R. Rylander |
| collection | DOAJ |
| description | Exposure to dust may involve co-exposure to agents which are allergens, together with those which are pro-inflamm atory. To study the effects of such a coexposure, the humoral and inflammatory responses were studied in guinea pigs inhaling the T-cell dependent antigen ovalbumin (OVA) and the inflammatory agents (1→3)-β -D-glucan and lipopolysaccharide (LPS). The effects were evaluated as inflammatory cells in the lung and serum antibodies to OVA. LPS caused a stimulation of the OVA-induced antibody production which was abolished by simultaneous exposure to (1→3)-β-D-glucan. An increase of eosinophils after OVA exposure was decreased by coexposure to (1→3)-β-D-glucan. The results demonstrate a complex interaction between adaptive and innate immune mechanisms in the lung, determined by exposure to common contaminants in airborne dust. |
| format | Article |
| id | doaj-art-9498f1dc7991469b866ba7d72caa07dd |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1998-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9498f1dc7991469b866ba7d72caa07dd2025-02-03T05:58:42ZengWileyMediators of Inflammation0962-93511466-18611998-01-017210511010.1080/09629359891252(1 →3)- β -D-Glucan and endotoxin modulate immune response to inhaled allergenR. Rylander0P. G. Holt1Department of Environmental Medicine, University of Gothenburg, Box 414, Gothenburg 40530, SwedenWestern Australian Research Institute for Child Health, Princess Margaret Hospital for Children, Subiaco, Western Australia, AustraliaExposure to dust may involve co-exposure to agents which are allergens, together with those which are pro-inflamm atory. To study the effects of such a coexposure, the humoral and inflammatory responses were studied in guinea pigs inhaling the T-cell dependent antigen ovalbumin (OVA) and the inflammatory agents (1→3)-β -D-glucan and lipopolysaccharide (LPS). The effects were evaluated as inflammatory cells in the lung and serum antibodies to OVA. LPS caused a stimulation of the OVA-induced antibody production which was abolished by simultaneous exposure to (1→3)-β-D-glucan. An increase of eosinophils after OVA exposure was decreased by coexposure to (1→3)-β-D-glucan. The results demonstrate a complex interaction between adaptive and innate immune mechanisms in the lung, determined by exposure to common contaminants in airborne dust.http://dx.doi.org/10.1080/09629359891252(1→3)β-D-glucanEndotoxinT-cellsEosinophilsInflammation. |
| spellingShingle | R. Rylander P. G. Holt (1 →3)- β -D-Glucan and endotoxin modulate immune response to inhaled allergen Mediators of Inflammation (1→3)β-D-glucan Endotoxin T-cells Eosinophils Inflammation. |
| title | (1 →3)- β -D-Glucan and endotoxin modulate immune response to inhaled allergen |
| title_full | (1 →3)- β -D-Glucan and endotoxin modulate immune response to inhaled allergen |
| title_fullStr | (1 →3)- β -D-Glucan and endotoxin modulate immune response to inhaled allergen |
| title_full_unstemmed | (1 →3)- β -D-Glucan and endotoxin modulate immune response to inhaled allergen |
| title_short | (1 →3)- β -D-Glucan and endotoxin modulate immune response to inhaled allergen |
| title_sort | 1 3 β d glucan and endotoxin modulate immune response to inhaled allergen |
| topic | (1→3)β-D-glucan Endotoxin T-cells Eosinophils Inflammation. |
| url | http://dx.doi.org/10.1080/09629359891252 |
| work_keys_str_mv | AT rrylander 13bdglucanandendotoxinmodulateimmuneresponsetoinhaledallergen AT pgholt 13bdglucanandendotoxinmodulateimmuneresponsetoinhaledallergen |