Primary Small Cell Carcinoma of the Vagina
The primary small cell carcinoma of the vagina is rare, and it is a highly aggressive malignancy with no consensus regarding the treatment of this tumor. The survival rate for patients treated in the early stages is around two years. We related the case report of a patient of 41 years with a vegetat...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2013/827037 |
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| _version_ | 1832556483818029056 |
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| author | Rafael Oliveira Mayra Coelho Bócoli João Carlos Saldanha Eddie Fernando Candido Murta Rosekeila Simões Nomelini |
| author_facet | Rafael Oliveira Mayra Coelho Bócoli João Carlos Saldanha Eddie Fernando Candido Murta Rosekeila Simões Nomelini |
| author_sort | Rafael Oliveira |
| collection | DOAJ |
| description | The primary small cell carcinoma of the vagina is rare, and it is a highly aggressive malignancy with no consensus regarding the treatment of this tumor. The survival rate for patients treated in the early stages is around two years. We related the case report of a patient of 41 years with a vegetative and necrotic lesion in left vaginal wall, in middle and upper third, and involvement of parametrium in its proximal third and medium third. A biopsy showed a small cell undifferentiated carcinoma composed of epithelial cells with round nuclei, oval or elongated, hyperchromatic nuclei, with little distinct nucleoli, and scarce cytoplasm. Immunohistochemistry showed positivity for AE1/AE3, CD57, and chromogranin A. The patient received 6 cycles of chemotherapy with cisplatin and etoposide and radiotherapy, achieving complete response, with complete regression of the lesion. The patient had no sign of tumor recurrence and locoregional or distant metastases after 5 months of followup. |
| format | Article |
| id | doaj-art-94986812170a4b838de07619583cd0ee |
| institution | Kabale University |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-94986812170a4b838de07619583cd0ee2025-02-03T05:45:22ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922013-01-01201310.1155/2013/827037827037Primary Small Cell Carcinoma of the VaginaRafael Oliveira0Mayra Coelho Bócoli1João Carlos Saldanha2Eddie Fernando Candido Murta3Rosekeila Simões Nomelini4Research Institute of Oncology (IPON), Discipline of Gynecology and Obstetrics, Federal University of Triângulo Mineiro (UFTM), Avenida Getúlio Guaritá 214, 38025-440 Uberaba, MG, BrazilResearch Institute of Oncology (IPON), Discipline of Gynecology and Obstetrics, Federal University of Triângulo Mineiro (UFTM), Avenida Getúlio Guaritá 214, 38025-440 Uberaba, MG, BrazilDiscipline of Surgical Pathology, Federal University of Triângulo Mineiro (UFTM), Uberaba, MG, BrazilResearch Institute of Oncology (IPON), Discipline of Gynecology and Obstetrics, Federal University of Triângulo Mineiro (UFTM), Avenida Getúlio Guaritá 214, 38025-440 Uberaba, MG, BrazilResearch Institute of Oncology (IPON), Discipline of Gynecology and Obstetrics, Federal University of Triângulo Mineiro (UFTM), Avenida Getúlio Guaritá 214, 38025-440 Uberaba, MG, BrazilThe primary small cell carcinoma of the vagina is rare, and it is a highly aggressive malignancy with no consensus regarding the treatment of this tumor. The survival rate for patients treated in the early stages is around two years. We related the case report of a patient of 41 years with a vegetative and necrotic lesion in left vaginal wall, in middle and upper third, and involvement of parametrium in its proximal third and medium third. A biopsy showed a small cell undifferentiated carcinoma composed of epithelial cells with round nuclei, oval or elongated, hyperchromatic nuclei, with little distinct nucleoli, and scarce cytoplasm. Immunohistochemistry showed positivity for AE1/AE3, CD57, and chromogranin A. The patient received 6 cycles of chemotherapy with cisplatin and etoposide and radiotherapy, achieving complete response, with complete regression of the lesion. The patient had no sign of tumor recurrence and locoregional or distant metastases after 5 months of followup.http://dx.doi.org/10.1155/2013/827037 |
| spellingShingle | Rafael Oliveira Mayra Coelho Bócoli João Carlos Saldanha Eddie Fernando Candido Murta Rosekeila Simões Nomelini Primary Small Cell Carcinoma of the Vagina Case Reports in Obstetrics and Gynecology |
| title | Primary Small Cell Carcinoma of the Vagina |
| title_full | Primary Small Cell Carcinoma of the Vagina |
| title_fullStr | Primary Small Cell Carcinoma of the Vagina |
| title_full_unstemmed | Primary Small Cell Carcinoma of the Vagina |
| title_short | Primary Small Cell Carcinoma of the Vagina |
| title_sort | primary small cell carcinoma of the vagina |
| url | http://dx.doi.org/10.1155/2013/827037 |
| work_keys_str_mv | AT rafaeloliveira primarysmallcellcarcinomaofthevagina AT mayracoelhobocoli primarysmallcellcarcinomaofthevagina AT joaocarlossaldanha primarysmallcellcarcinomaofthevagina AT eddiefernandocandidomurta primarysmallcellcarcinomaofthevagina AT rosekeilasimoesnomelini primarysmallcellcarcinomaofthevagina |