Profiling Rosmarinic Acid and Sinensetin Content of Orthosiphon aristatus. from Three Different Locations with Variety Ethanol Concentration
Orthosiphon aristatus is a well-known medicinal plant acknowledged for its therapeutic effect in treating urinary tract diseases, hypertension, diabetes mellitus, and arthritis. It is widely used as an ingredient in herbal medicine and distributed throughout the world, including China, Europe and In...
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LPPT Universitas Gadjah Mada
2024-08-01
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| Series: | Journal of Food and Pharmaceutical Sciences |
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| Online Access: | https://jurnal.ugm.ac.id/v3/JFPS/article/view/13625/4839 |
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| author | Novia Putri Ramadhani Yosi Bayu Murti Andayana Puspitasari Gani |
| author_facet | Novia Putri Ramadhani Yosi Bayu Murti Andayana Puspitasari Gani |
| author_sort | Novia Putri Ramadhani |
| collection | DOAJ |
| description | Orthosiphon aristatus is a well-known medicinal plant acknowledged for its therapeutic effect in treating urinary tract diseases, hypertension, diabetes mellitus, and arthritis. It is widely used as an ingredient in herbal medicine and distributed throughout the world, including China, Europe and Indonesia. Sinensetin are normally used as chemical marker to evaluate and control the quality of O. aristatus. However, in 2021, the European Medicines Agency changed the marker to rosmarinic acid. In order to determine the levels of rosmarinic acid and sinensetin in O. aristatus as well as the correlation between the two compounds, this study used high-performance liquid chromatography (HPLC) with a UV detector to analyze O. aristatus extract from three distinct locations with four different ethanol concentrations (96%, 75%, 50%, and 25%). Results showed that higher levels of rosmarinic acid was obtained in extractions using binary. Meanwhile, higher sinensetin content in O. aristatus were obtained by 96% ethanol (Klaten) and hydro-ethanol (Sleman, Bantul). In addition, this study discovered that the sinensetin levels had an inverse correlation with rosmarinic acid levels. It can be concluded that the rosmarinic acid and sinensetin contents are influenced by growing locations and ethanol concentrations. |
| format | Article |
| id | doaj-art-9496f90f765e449194718ee1c5c0563e |
| institution | Kabale University |
| issn | 2089-7200 2339-0948 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | LPPT Universitas Gadjah Mada |
| record_format | Article |
| series | Journal of Food and Pharmaceutical Sciences |
| spelling | doaj-art-9496f90f765e449194718ee1c5c0563e2025-01-24T09:04:51ZengLPPT Universitas Gadjah MadaJournal of Food and Pharmaceutical Sciences2089-72002339-09482024-08-0112211612410.22146/jfps.13625Profiling Rosmarinic Acid and Sinensetin Content of Orthosiphon aristatus. from Three Different Locations with Variety Ethanol ConcentrationNovia Putri Ramadhani0Yosi Bayu Murti1Andayana Puspitasari Gani2Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, IndonesiaFaculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, IndonesiaFaculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, IndonesiaOrthosiphon aristatus is a well-known medicinal plant acknowledged for its therapeutic effect in treating urinary tract diseases, hypertension, diabetes mellitus, and arthritis. It is widely used as an ingredient in herbal medicine and distributed throughout the world, including China, Europe and Indonesia. Sinensetin are normally used as chemical marker to evaluate and control the quality of O. aristatus. However, in 2021, the European Medicines Agency changed the marker to rosmarinic acid. In order to determine the levels of rosmarinic acid and sinensetin in O. aristatus as well as the correlation between the two compounds, this study used high-performance liquid chromatography (HPLC) with a UV detector to analyze O. aristatus extract from three distinct locations with four different ethanol concentrations (96%, 75%, 50%, and 25%). Results showed that higher levels of rosmarinic acid was obtained in extractions using binary. Meanwhile, higher sinensetin content in O. aristatus were obtained by 96% ethanol (Klaten) and hydro-ethanol (Sleman, Bantul). In addition, this study discovered that the sinensetin levels had an inverse correlation with rosmarinic acid levels. It can be concluded that the rosmarinic acid and sinensetin contents are influenced by growing locations and ethanol concentrations.https://jurnal.ugm.ac.id/v3/JFPS/article/view/13625/4839orthosiphon aristatusrosmarinic acidsinensetinethanol concentration |
| spellingShingle | Novia Putri Ramadhani Yosi Bayu Murti Andayana Puspitasari Gani Profiling Rosmarinic Acid and Sinensetin Content of Orthosiphon aristatus. from Three Different Locations with Variety Ethanol Concentration Journal of Food and Pharmaceutical Sciences orthosiphon aristatus rosmarinic acid sinensetin ethanol concentration |
| title | Profiling Rosmarinic Acid and Sinensetin Content of Orthosiphon aristatus. from Three Different Locations with Variety Ethanol Concentration |
| title_full | Profiling Rosmarinic Acid and Sinensetin Content of Orthosiphon aristatus. from Three Different Locations with Variety Ethanol Concentration |
| title_fullStr | Profiling Rosmarinic Acid and Sinensetin Content of Orthosiphon aristatus. from Three Different Locations with Variety Ethanol Concentration |
| title_full_unstemmed | Profiling Rosmarinic Acid and Sinensetin Content of Orthosiphon aristatus. from Three Different Locations with Variety Ethanol Concentration |
| title_short | Profiling Rosmarinic Acid and Sinensetin Content of Orthosiphon aristatus. from Three Different Locations with Variety Ethanol Concentration |
| title_sort | profiling rosmarinic acid and sinensetin content of orthosiphon aristatus from three different locations with variety ethanol concentration |
| topic | orthosiphon aristatus rosmarinic acid sinensetin ethanol concentration |
| url | https://jurnal.ugm.ac.id/v3/JFPS/article/view/13625/4839 |
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