Diffusion Kurtosis Imaging of Substantia Nigra Is a Sensitive Method for Early Diagnosis and Disease Evaluation in Parkinson’s Disease
Background. To diagnose Parkinson disease (PD) in an early stage and accurately evaluate severity, it is important to develop a sensitive method for detecting structural changes in the substantia nigra (SN). Method. Seventy-two untreated patients with early PD and 72 healthy controls underwent diffu...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2015/207624 |
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| _version_ | 1849402813516349440 |
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| author | Guohua Zhang Yuhu Zhang Chengguo Zhang Yukai Wang Guixian Ma Kun Nie Haiqun Xie Jianping Liu Lijuan Wang |
| author_facet | Guohua Zhang Yuhu Zhang Chengguo Zhang Yukai Wang Guixian Ma Kun Nie Haiqun Xie Jianping Liu Lijuan Wang |
| author_sort | Guohua Zhang |
| collection | DOAJ |
| description | Background. To diagnose Parkinson disease (PD) in an early stage and accurately evaluate severity, it is important to develop a sensitive method for detecting structural changes in the substantia nigra (SN). Method. Seventy-two untreated patients with early PD and 72 healthy controls underwent diffusion tensor and diffusion kurtosis imaging. Regions of interest were drawn in the rostral, middle, and caudal SN by two blinded and independent raters. Mean kurtosis (MK) and fractional anisotropy in the SN were compared between the groups. Receiver operating characteristic (ROC) and Spearman correlation analyses were used to compare the diagnostic accuracy and correlate imaging findings with Hoehn-Yahr (H-Y) staging and part III of the Unified Parkinson’s Disease Rating Scale (UPDRS-III). Result. MK in the SN was increased significantly in PD patients compared with healthy controls. The area under the ROC curve was 0.976 for MK in the SN (sensitivity, 0.944; specificity, 0.917). MK in the SN had a positive correlation with H-Y staging and UPDRS-III scores. Conclusion. Diffusion kurtosis imaging is a sensitive method for PD diagnosis and severity evaluation. MK in the SN is a potential biomarker for imaging studies of early PD that can be widely used in clinic. |
| format | Article |
| id | doaj-art-94945c5378604e2a99bb2e43619d9561 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-94945c5378604e2a99bb2e43619d95612025-08-20T03:37:27ZengWileyParkinson's Disease2090-80832042-00802015-01-01201510.1155/2015/207624207624Diffusion Kurtosis Imaging of Substantia Nigra Is a Sensitive Method for Early Diagnosis and Disease Evaluation in Parkinson’s DiseaseGuohua Zhang0Yuhu Zhang1Chengguo Zhang2Yukai Wang3Guixian Ma4Kun Nie5Haiqun Xie6Jianping Liu7Lijuan Wang8Southern Medical University, Guangzhou, Guangdong 510515, ChinaDepartment of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, ChinaDepartment of Neurology, The First People’s Hospital of Foshan, Foshan, Guangdong 528000, ChinaDepartment of Neurology, The First People’s Hospital of Foshan, Foshan, Guangdong 528000, ChinaDepartment of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, ChinaDepartment of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, ChinaDepartment of Neurology, The First People’s Hospital of Foshan, Foshan, Guangdong 528000, ChinaDepartment of Neurology, The First People’s Hospital of Foshan, Foshan, Guangdong 528000, ChinaDepartment of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, ChinaBackground. To diagnose Parkinson disease (PD) in an early stage and accurately evaluate severity, it is important to develop a sensitive method for detecting structural changes in the substantia nigra (SN). Method. Seventy-two untreated patients with early PD and 72 healthy controls underwent diffusion tensor and diffusion kurtosis imaging. Regions of interest were drawn in the rostral, middle, and caudal SN by two blinded and independent raters. Mean kurtosis (MK) and fractional anisotropy in the SN were compared between the groups. Receiver operating characteristic (ROC) and Spearman correlation analyses were used to compare the diagnostic accuracy and correlate imaging findings with Hoehn-Yahr (H-Y) staging and part III of the Unified Parkinson’s Disease Rating Scale (UPDRS-III). Result. MK in the SN was increased significantly in PD patients compared with healthy controls. The area under the ROC curve was 0.976 for MK in the SN (sensitivity, 0.944; specificity, 0.917). MK in the SN had a positive correlation with H-Y staging and UPDRS-III scores. Conclusion. Diffusion kurtosis imaging is a sensitive method for PD diagnosis and severity evaluation. MK in the SN is a potential biomarker for imaging studies of early PD that can be widely used in clinic.http://dx.doi.org/10.1155/2015/207624 |
| spellingShingle | Guohua Zhang Yuhu Zhang Chengguo Zhang Yukai Wang Guixian Ma Kun Nie Haiqun Xie Jianping Liu Lijuan Wang Diffusion Kurtosis Imaging of Substantia Nigra Is a Sensitive Method for Early Diagnosis and Disease Evaluation in Parkinson’s Disease Parkinson's Disease |
| title | Diffusion Kurtosis Imaging of Substantia Nigra Is a Sensitive Method for Early Diagnosis and Disease Evaluation in Parkinson’s Disease |
| title_full | Diffusion Kurtosis Imaging of Substantia Nigra Is a Sensitive Method for Early Diagnosis and Disease Evaluation in Parkinson’s Disease |
| title_fullStr | Diffusion Kurtosis Imaging of Substantia Nigra Is a Sensitive Method for Early Diagnosis and Disease Evaluation in Parkinson’s Disease |
| title_full_unstemmed | Diffusion Kurtosis Imaging of Substantia Nigra Is a Sensitive Method for Early Diagnosis and Disease Evaluation in Parkinson’s Disease |
| title_short | Diffusion Kurtosis Imaging of Substantia Nigra Is a Sensitive Method for Early Diagnosis and Disease Evaluation in Parkinson’s Disease |
| title_sort | diffusion kurtosis imaging of substantia nigra is a sensitive method for early diagnosis and disease evaluation in parkinson s disease |
| url | http://dx.doi.org/10.1155/2015/207624 |
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