A proliferation-inducing ligand (APRIL) level among risk factors of ocular involvement in patients with Behçet’s disease
Introduction Ocular involvement is quite common in Behçet’s disease (BD) and may cause crucial functional complications. Even though the mechanisms of BD remain unclear, advances in genetic and immunological fields have improved our understanding of the immunopathogenesis of BD ocular involvement....
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2024-11-01
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| Series: | Rheumatology |
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| Online Access: | https://reu.termedia.pl/A-proliferation-inducing-ligand-APRIL-level-among-risk-factors-of-ocular-involvement,194113,0,2.html |
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| author | Rasha M. Ghaleb Hanan S. Gad Mohamed I. Abdallah Zaki M. Zaki Jehan A. Mahmoud |
| author_facet | Rasha M. Ghaleb Hanan S. Gad Mohamed I. Abdallah Zaki M. Zaki Jehan A. Mahmoud |
| author_sort | Rasha M. Ghaleb |
| collection | DOAJ |
| description | Introduction
Ocular involvement is quite common in Behçet’s disease (BD) and may cause crucial functional complications. Even though the mechanisms of BD remain unclear, advances in genetic and immunological fields have improved our understanding of the immunopathogenesis of BD ocular involvement. Little is known about the expression of a proliferation-inducing ligand (APRIL) in terms of ocular involvement in BD. The objective of this study was to determine whether serum APRIL concentrations are associated with ocular involvement in patients with BD.
Material and methods
The study included 60 patients diagnosed with BD matched by age and sex to 30 healthy individuals. Every patient underwent a clinical evaluation, and the Behçet’s Disease Current Activity Form (BDCAF) was utilized to quantify disease activity. All patients underwent a comprehensive ophthalmological assessment. Serum APRIL was assessed for patients as well as controls.
Results
One or more ocular manifestations were found in 42 BD patients (70%), while 18 patients (30%) had no ocular involvement. The mean level of serum APRIL levels was markedly elevated in BD patients, particularly those with ocular involvement, compared to both BD patients without ocular involvement and healthy individuals. A statistically significant association was determined between high APRIL concentration and development of uveitis, cataract, and hypopyon. Cutaneous lesions and arthritis were strong independent predictors for ocular involvement in BD patients.
Conclusions
Overexpression of APRIL in patients with BD, particularly in terms of uveitis, cataract, and hypopyon, lends credence to the idea that B cell activating factors have an important function in BD. These findings may indicate that serum APRIL concentrations can differentiate a clinical subgroup of BD patients with ocular disease. As a result, finding a new therapeutic strategy targeting the APRIL pathway might be beneficial in BD patients suffering from ocular involvement. |
| format | Article |
| id | doaj-art-94941672678742c0bbf48efbce7b02c4 |
| institution | Kabale University |
| issn | 0034-6233 2084-9834 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Rheumatology |
| spelling | doaj-art-94941672678742c0bbf48efbce7b02c42025-01-27T11:20:37ZengTermedia Publishing HouseRheumatology0034-62332084-98342024-11-0162531432110.5114/reum/194113194113A proliferation-inducing ligand (APRIL) level among risk factors of ocular involvement in patients with Behçet’s diseaseRasha M. Ghaleb0https://orcid.org/0000-0003-4283-9034Hanan S. Gad1Mohamed I. Abdallah2Zaki M. Zaki3Jehan A. Mahmoud4Department of Rheumatology and Rehabilitation, Minia University, EgyptDepartment of Rheumatology and Rehabilitation, Minia University, EgyptDepartment of Ophthalmology, Minia University, EgyptDepartment of Clinical Pathology, Minia University, EgyptDepartment of Rheumatology and Rehabilitation, Minia University, EgyptIntroduction Ocular involvement is quite common in Behçet’s disease (BD) and may cause crucial functional complications. Even though the mechanisms of BD remain unclear, advances in genetic and immunological fields have improved our understanding of the immunopathogenesis of BD ocular involvement. Little is known about the expression of a proliferation-inducing ligand (APRIL) in terms of ocular involvement in BD. The objective of this study was to determine whether serum APRIL concentrations are associated with ocular involvement in patients with BD. Material and methods The study included 60 patients diagnosed with BD matched by age and sex to 30 healthy individuals. Every patient underwent a clinical evaluation, and the Behçet’s Disease Current Activity Form (BDCAF) was utilized to quantify disease activity. All patients underwent a comprehensive ophthalmological assessment. Serum APRIL was assessed for patients as well as controls. Results One or more ocular manifestations were found in 42 BD patients (70%), while 18 patients (30%) had no ocular involvement. The mean level of serum APRIL levels was markedly elevated in BD patients, particularly those with ocular involvement, compared to both BD patients without ocular involvement and healthy individuals. A statistically significant association was determined between high APRIL concentration and development of uveitis, cataract, and hypopyon. Cutaneous lesions and arthritis were strong independent predictors for ocular involvement in BD patients. Conclusions Overexpression of APRIL in patients with BD, particularly in terms of uveitis, cataract, and hypopyon, lends credence to the idea that B cell activating factors have an important function in BD. These findings may indicate that serum APRIL concentrations can differentiate a clinical subgroup of BD patients with ocular disease. As a result, finding a new therapeutic strategy targeting the APRIL pathway might be beneficial in BD patients suffering from ocular involvement.https://reu.termedia.pl/A-proliferation-inducing-ligand-APRIL-level-among-risk-factors-of-ocular-involvement,194113,0,2.htmlbehçet’s diseaseaprilocular |
| spellingShingle | Rasha M. Ghaleb Hanan S. Gad Mohamed I. Abdallah Zaki M. Zaki Jehan A. Mahmoud A proliferation-inducing ligand (APRIL) level among risk factors of ocular involvement in patients with Behçet’s disease Rheumatology behçet’s disease april ocular |
| title | A proliferation-inducing ligand (APRIL) level among risk factors of ocular involvement in patients with Behçet’s disease |
| title_full | A proliferation-inducing ligand (APRIL) level among risk factors of ocular involvement in patients with Behçet’s disease |
| title_fullStr | A proliferation-inducing ligand (APRIL) level among risk factors of ocular involvement in patients with Behçet’s disease |
| title_full_unstemmed | A proliferation-inducing ligand (APRIL) level among risk factors of ocular involvement in patients with Behçet’s disease |
| title_short | A proliferation-inducing ligand (APRIL) level among risk factors of ocular involvement in patients with Behçet’s disease |
| title_sort | proliferation inducing ligand april level among risk factors of ocular involvement in patients with behcet s disease |
| topic | behçet’s disease april ocular |
| url | https://reu.termedia.pl/A-proliferation-inducing-ligand-APRIL-level-among-risk-factors-of-ocular-involvement,194113,0,2.html |
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