Traditional usages, chemical metabolites, pharmacological activities, and pharmacokinetics of Boesenbergia rotunda (L.) Mansf.: a comprehensive review
Boesenbergia rotunda: (L.) Mansf. (family Zingiberaceae), also known as fingerroot, is a medicinal and food plant that is widely distributed in southern China, Southeast Asia, and South Asia. It is a traditional herb and spice that is also known for its beneficial effects on Qi, appetite, stagnation...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1527210/full |
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| author | Yan Wang Juanjuan Wen Feng Liu Feng Liu Xiujuan Peng Gang Xu Mingliang Zhang Zhuangzhuang Huang Zhuangzhuang Huang |
| author_facet | Yan Wang Juanjuan Wen Feng Liu Feng Liu Xiujuan Peng Gang Xu Mingliang Zhang Zhuangzhuang Huang Zhuangzhuang Huang |
| author_sort | Yan Wang |
| collection | DOAJ |
| description | Boesenbergia rotunda: (L.) Mansf. (family Zingiberaceae), also known as fingerroot, is a medicinal and food plant that is widely distributed in southern China, Southeast Asia, and South Asia. It is a traditional herb and spice that is also known for its beneficial effects on Qi, appetite, stagnation and pain relief. The objective of this study is to conduct a comprehensive and systematic review of the botanical characteristics, traditional applications, phytochemical metabolites, pharmacological properties, toxicology, quality control measures, pharmacokinetics, and clinical applications of B. rotunda. A bibliometric analysis of current studies on B. rotunda was also conducted to facilitate further exploration and utilization of B. rotunda in the functional food and pharmaceutical industries. These data were collected from PubMed, Web of Science, Google Scholar, China National Knowledge Infrastructure doctoral and master’s theses and other books and scientific databases by searching the keywords Boesenbergia rotunda. Phytochemical analysis has revealed the presence of flavonoids, monoterpenes, alkaloids, aromatic metabolites, phenols, and other metabolites in B. rotunda, exhibiting a wide range of biological activities such as anti-cancer, nephroprotective, anti-inflammatory, anti-bacterial, hepatoprotective, anti-obesity, and anti-oxidant effects, both in vivo and in vitro. In this paper, the research of B. rotunda is discussed in depth by combining traditional application and modern pharmacological research, aiming to provide valuable reference for the future research and practical application of B. rotunda. |
| format | Article |
| id | doaj-art-949206ef1019478bbb989dff56c9dcb5 |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-949206ef1019478bbb989dff56c9dcb52025-08-20T02:07:20ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-03-011610.3389/fphar.2025.15272101527210Traditional usages, chemical metabolites, pharmacological activities, and pharmacokinetics of Boesenbergia rotunda (L.) Mansf.: a comprehensive reviewYan Wang0Juanjuan Wen1Feng Liu2Feng Liu3Xiujuan Peng4Gang Xu5Mingliang Zhang6Zhuangzhuang Huang7Zhuangzhuang Huang8Key Laboratory of Chemical Substances and Biological Effects in Traditional Chinese Medicine, College of Medicine and Pharmacy, Shaanxi Institute of International Trade & Commerce, Xi’an, Shaanxi, ChinaKey Laboratory of Chemical Substances and Biological Effects in Traditional Chinese Medicine, College of Medicine and Pharmacy, Shaanxi Institute of International Trade & Commerce, Xi’an, Shaanxi, ChinaKey Laboratory of Chemical Substances and Biological Effects in Traditional Chinese Medicine, College of Medicine and Pharmacy, Shaanxi Institute of International Trade & Commerce, Xi’an, Shaanxi, ChinaShaanxi Buchang Pharmaceutical Co. Ltd, Xi’an, Shaanxi, ChinaKey Laboratory of Chemical Substances and Biological Effects in Traditional Chinese Medicine, College of Medicine and Pharmacy, Shaanxi Institute of International Trade & Commerce, Xi’an, Shaanxi, ChinaKey Laboratory of Chemical Substances and Biological Effects in Traditional Chinese Medicine, College of Medicine and Pharmacy, Shaanxi Institute of International Trade & Commerce, Xi’an, Shaanxi, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, ChinaKey Laboratory of Chemical Substances and Biological Effects in Traditional Chinese Medicine, College of Medicine and Pharmacy, Shaanxi Institute of International Trade & Commerce, Xi’an, Shaanxi, ChinaShaanxi Buchang Pharmaceutical Co. Ltd, Xi’an, Shaanxi, ChinaBoesenbergia rotunda: (L.) Mansf. (family Zingiberaceae), also known as fingerroot, is a medicinal and food plant that is widely distributed in southern China, Southeast Asia, and South Asia. It is a traditional herb and spice that is also known for its beneficial effects on Qi, appetite, stagnation and pain relief. The objective of this study is to conduct a comprehensive and systematic review of the botanical characteristics, traditional applications, phytochemical metabolites, pharmacological properties, toxicology, quality control measures, pharmacokinetics, and clinical applications of B. rotunda. A bibliometric analysis of current studies on B. rotunda was also conducted to facilitate further exploration and utilization of B. rotunda in the functional food and pharmaceutical industries. These data were collected from PubMed, Web of Science, Google Scholar, China National Knowledge Infrastructure doctoral and master’s theses and other books and scientific databases by searching the keywords Boesenbergia rotunda. Phytochemical analysis has revealed the presence of flavonoids, monoterpenes, alkaloids, aromatic metabolites, phenols, and other metabolites in B. rotunda, exhibiting a wide range of biological activities such as anti-cancer, nephroprotective, anti-inflammatory, anti-bacterial, hepatoprotective, anti-obesity, and anti-oxidant effects, both in vivo and in vitro. In this paper, the research of B. rotunda is discussed in depth by combining traditional application and modern pharmacological research, aiming to provide valuable reference for the future research and practical application of B. rotunda.https://www.frontiersin.org/articles/10.3389/fphar.2025.1527210/fullBoesenbergia rotunda (L.) Mansftraditional usagesflavonoidsanti-cancer activityquality controltoxicology |
| spellingShingle | Yan Wang Juanjuan Wen Feng Liu Feng Liu Xiujuan Peng Gang Xu Mingliang Zhang Zhuangzhuang Huang Zhuangzhuang Huang Traditional usages, chemical metabolites, pharmacological activities, and pharmacokinetics of Boesenbergia rotunda (L.) Mansf.: a comprehensive review Frontiers in Pharmacology Boesenbergia rotunda (L.) Mansf traditional usages flavonoids anti-cancer activity quality control toxicology |
| title | Traditional usages, chemical metabolites, pharmacological activities, and pharmacokinetics of Boesenbergia rotunda (L.) Mansf.: a comprehensive review |
| title_full | Traditional usages, chemical metabolites, pharmacological activities, and pharmacokinetics of Boesenbergia rotunda (L.) Mansf.: a comprehensive review |
| title_fullStr | Traditional usages, chemical metabolites, pharmacological activities, and pharmacokinetics of Boesenbergia rotunda (L.) Mansf.: a comprehensive review |
| title_full_unstemmed | Traditional usages, chemical metabolites, pharmacological activities, and pharmacokinetics of Boesenbergia rotunda (L.) Mansf.: a comprehensive review |
| title_short | Traditional usages, chemical metabolites, pharmacological activities, and pharmacokinetics of Boesenbergia rotunda (L.) Mansf.: a comprehensive review |
| title_sort | traditional usages chemical metabolites pharmacological activities and pharmacokinetics of boesenbergia rotunda l mansf a comprehensive review |
| topic | Boesenbergia rotunda (L.) Mansf traditional usages flavonoids anti-cancer activity quality control toxicology |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1527210/full |
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