Dysfunction of PDE4DIP contributes to LVNC development by regulating cell polarity, skeleton, and energy metabolism via Rho-ROCK pathway

Dysfunction of PDE4DIP contributes to LVNC development by regulating cell polarity, skeleton, and energy metabolism via Rho-ROCK pathway

Left ventricular non-compaction (LVNC), is a hereditary cardiomyopathy with limited treatments. Our previous study linked phosphodiesterase 4D interacting protein (PDE4DIP) to LVNC development. To explore the functional role of PDE4DIP activation in regulating cell polarity, skeleton, and energy met...

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Bibliographic Details
Main Authors: Wuxia Gu, Hongyan Li, Wenjing Yuan, Xiaoqiong Fu, Rui Wang, Xiaohui Xu, Xuemei Liao, LingJuan Liu, Bo Pan, Jie Tian, Haixin Yuan, Yi Huang, Tiewei Lu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-09-01
Series:Genes and Diseases
Subjects:
Cell polarity
Cytoskeleton
Left ventricular non-compaction
Mitochondria
PDE4DIP
Rho-ROCK
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304225000571
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