Clinicopathological and Molecular Features of Primary Inflammatory Myofibroblastic Tumor in Nasal Cavity and Paranasal Sinuses
Yihua Zhao, Donglin Ma, Hongfei Wan, Yingshi Piao Department of Pathology, Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing Tongren Hospital, Capital Medical University; Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing, 100730, People’s R...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-04-01
|
| Series: | Pharmacogenomics and Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/clinicopathological-and-molecular-features-of-primary-inflammatory-myo-peer-reviewed-fulltext-article-PGPM |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849714315894980608 |
|---|---|
| author | Zhao Y Ma D Wan H Piao Y |
| author_facet | Zhao Y Ma D Wan H Piao Y |
| author_sort | Zhao Y |
| collection | DOAJ |
| description | Yihua Zhao, Donglin Ma, Hongfei Wan, Yingshi Piao Department of Pathology, Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing Tongren Hospital, Capital Medical University; Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing, 100730, People’s Republic of ChinaCorrespondence: Yingshi Piao, Email piaoyingshi2013@163.comBackground: Inflammatory myofibroblastic tumor (IMT) in the nasal cavity and sinuses is rare and has special clinical and pathological characteristics with poor prognosis. This study aimed to investigate the clinicopathological and molecular features of primary IMT in the nasal cavity and paranasal sinuses.Methods: The clinical features, histopathological findings, immunohistochemical findings and results of molecular genetic examination were retrospectively analyzed in 25 patients who were diagnosed with IMT in the nasal cavity and paranasal sinuses.Results: Tumor tissues were mainly composed of obese spindle-shaped myofibroblasts, fibroblasts, and chronic inflammatory cells. The inflammatory cells included plasma cells, lymphocytes, eosinophils, foam histiocytes and multinuclear giant cells. Immunohistochemical staining showed the tumor was positive to anaplastic lymphoma kinase (ALK) in two patients. ALK fusion mutation was detected by PCR in only 1 patient.Conclusion: Nasal and paranasal sinus IMTs are rare, exhibit histopathological diversity with low specificity, and require careful differentiation from inflammatory and autoimmune disorders. These tumors demonstrate a worse prognosis compared to IMTs in other anatomic locations, along with a significantly lower rate of ALK gene rearrangement. Identifying molecular target alterations can enhance precision diagnosis and targeted therapeutic strategies.Keywords: inflammatory myofibroblastic tumor, nasal cavity, paranasal sinuses, anaplastic lymphoma kinase, clinicopathology |
| format | Article |
| id | doaj-art-9490aa2248a44cd09850bcf9372a2ada |
| institution | DOAJ |
| issn | 1178-7066 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Pharmacogenomics and Personalized Medicine |
| spelling | doaj-art-9490aa2248a44cd09850bcf9372a2ada2025-08-20T03:13:44ZengDove Medical PressPharmacogenomics and Personalized Medicine1178-70662025-04-01Volume 1895104102474Clinicopathological and Molecular Features of Primary Inflammatory Myofibroblastic Tumor in Nasal Cavity and Paranasal SinusesZhao YMa DWan HPiao YYihua Zhao, Donglin Ma, Hongfei Wan, Yingshi Piao Department of Pathology, Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing Tongren Hospital, Capital Medical University; Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing, 100730, People’s Republic of ChinaCorrespondence: Yingshi Piao, Email piaoyingshi2013@163.comBackground: Inflammatory myofibroblastic tumor (IMT) in the nasal cavity and sinuses is rare and has special clinical and pathological characteristics with poor prognosis. This study aimed to investigate the clinicopathological and molecular features of primary IMT in the nasal cavity and paranasal sinuses.Methods: The clinical features, histopathological findings, immunohistochemical findings and results of molecular genetic examination were retrospectively analyzed in 25 patients who were diagnosed with IMT in the nasal cavity and paranasal sinuses.Results: Tumor tissues were mainly composed of obese spindle-shaped myofibroblasts, fibroblasts, and chronic inflammatory cells. The inflammatory cells included plasma cells, lymphocytes, eosinophils, foam histiocytes and multinuclear giant cells. Immunohistochemical staining showed the tumor was positive to anaplastic lymphoma kinase (ALK) in two patients. ALK fusion mutation was detected by PCR in only 1 patient.Conclusion: Nasal and paranasal sinus IMTs are rare, exhibit histopathological diversity with low specificity, and require careful differentiation from inflammatory and autoimmune disorders. These tumors demonstrate a worse prognosis compared to IMTs in other anatomic locations, along with a significantly lower rate of ALK gene rearrangement. Identifying molecular target alterations can enhance precision diagnosis and targeted therapeutic strategies.Keywords: inflammatory myofibroblastic tumor, nasal cavity, paranasal sinuses, anaplastic lymphoma kinase, clinicopathologyhttps://www.dovepress.com/clinicopathological-and-molecular-features-of-primary-inflammatory-myo-peer-reviewed-fulltext-article-PGPMinflammatory myofibroblastic tumornasal cavityparanasal sinusesanaplastic lymphoma kinaseclinicopathology |
| spellingShingle | Zhao Y Ma D Wan H Piao Y Clinicopathological and Molecular Features of Primary Inflammatory Myofibroblastic Tumor in Nasal Cavity and Paranasal Sinuses Pharmacogenomics and Personalized Medicine inflammatory myofibroblastic tumor nasal cavity paranasal sinuses anaplastic lymphoma kinase clinicopathology |
| title | Clinicopathological and Molecular Features of Primary Inflammatory Myofibroblastic Tumor in Nasal Cavity and Paranasal Sinuses |
| title_full | Clinicopathological and Molecular Features of Primary Inflammatory Myofibroblastic Tumor in Nasal Cavity and Paranasal Sinuses |
| title_fullStr | Clinicopathological and Molecular Features of Primary Inflammatory Myofibroblastic Tumor in Nasal Cavity and Paranasal Sinuses |
| title_full_unstemmed | Clinicopathological and Molecular Features of Primary Inflammatory Myofibroblastic Tumor in Nasal Cavity and Paranasal Sinuses |
| title_short | Clinicopathological and Molecular Features of Primary Inflammatory Myofibroblastic Tumor in Nasal Cavity and Paranasal Sinuses |
| title_sort | clinicopathological and molecular features of primary inflammatory myofibroblastic tumor in nasal cavity and paranasal sinuses |
| topic | inflammatory myofibroblastic tumor nasal cavity paranasal sinuses anaplastic lymphoma kinase clinicopathology |
| url | https://www.dovepress.com/clinicopathological-and-molecular-features-of-primary-inflammatory-myo-peer-reviewed-fulltext-article-PGPM |
| work_keys_str_mv | AT zhaoy clinicopathologicalandmolecularfeaturesofprimaryinflammatorymyofibroblastictumorinnasalcavityandparanasalsinuses AT mad clinicopathologicalandmolecularfeaturesofprimaryinflammatorymyofibroblastictumorinnasalcavityandparanasalsinuses AT wanh clinicopathologicalandmolecularfeaturesofprimaryinflammatorymyofibroblastictumorinnasalcavityandparanasalsinuses AT piaoy clinicopathologicalandmolecularfeaturesofprimaryinflammatorymyofibroblastictumorinnasalcavityandparanasalsinuses |