A Case of Successful Surgical Resection of Locally Advanced (T4) Lung Cancer Utilizing a Multi-Disciplinary Approach Involving Previously Unresectable Structures
Background: Lung cancer is the leading cause of cancer death worldwide and the second most prevalent cancer in the world.(1) Tumor node metastasis (TNM) staging continues to serve as the primary prognostic factor for survival in lung cancer. TNM classification (8th edition) characterizes T4...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University Library System, University of Pittsburgh
2025-06-01
|
| Series: | International Journal of Medical Students |
| Subjects: | |
| Online Access: | http://ijms.info/IJMS/article/view/2516 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849424820667678720 |
|---|---|
| author | Meadhbh Ni Mhiochain de Grae William P. Duggan Paul Carroll Alan Soo |
| author_facet | Meadhbh Ni Mhiochain de Grae William P. Duggan Paul Carroll Alan Soo |
| author_sort | Meadhbh Ni Mhiochain de Grae |
| collection | DOAJ |
| description |
Background:
Lung cancer is the leading cause of cancer death worldwide and the second most prevalent cancer in the world.(1) Tumor node metastasis (TNM) staging continues to serve as the primary prognostic factor for survival in lung cancer.
TNM classification (8th edition) characterizes T4 disease as a tumor exceeding 7 cm in its largest dimension or one that invades structures such as the mediastinum, diaphragm, heart, great vessels, recurrent laryngeal nerve, carina, trachea, esophagus, spine or represents a separate tumor in a different lobe of ipsilateral lung.(2) These structures are typically deemed “unresectable”.(3)
Case:
We present the case of an asymptomatic 66-year-old gentleman with an incidental lung nodule found on routine pre-operative chest x ray. In this case, imaging revealed local extension, involving the stomach (excluded from TNM classification), diaphragm and pericardium. Consequently, the disease was initially considered incurable. Nevertheless, through collaborative multi-disciplinary surgical approach, successful resection was achieved.
Conclusion:
T4 disease exhibits heterogeneity, and although it is typically deemed unresectable, recent developments in surgery are challenging this conventional belief and demonstrating the potential benefits of surgical resection, particularly where a radical dissection is anticipated.
|
| format | Article |
| id | doaj-art-948e309329274c2a9daa25e2ef29219f |
| institution | Kabale University |
| issn | 2076-6327 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | University Library System, University of Pittsburgh |
| record_format | Article |
| series | International Journal of Medical Students |
| spelling | doaj-art-948e309329274c2a9daa25e2ef29219f2025-08-20T03:29:58ZengUniversity Library System, University of PittsburghInternational Journal of Medical Students2076-63272025-06-0113210.5195/ijms.2025.2516A Case of Successful Surgical Resection of Locally Advanced (T4) Lung Cancer Utilizing a Multi-Disciplinary Approach Involving Previously Unresectable StructuresMeadhbh Ni Mhiochain de Grae0William P. Duggan 1Paul CarrollAlan SooUniversity of GalwayMD, Royal College of Surgeons, Dublin, Ireland Background: Lung cancer is the leading cause of cancer death worldwide and the second most prevalent cancer in the world.(1) Tumor node metastasis (TNM) staging continues to serve as the primary prognostic factor for survival in lung cancer. TNM classification (8th edition) characterizes T4 disease as a tumor exceeding 7 cm in its largest dimension or one that invades structures such as the mediastinum, diaphragm, heart, great vessels, recurrent laryngeal nerve, carina, trachea, esophagus, spine or represents a separate tumor in a different lobe of ipsilateral lung.(2) These structures are typically deemed “unresectable”.(3) Case: We present the case of an asymptomatic 66-year-old gentleman with an incidental lung nodule found on routine pre-operative chest x ray. In this case, imaging revealed local extension, involving the stomach (excluded from TNM classification), diaphragm and pericardium. Consequently, the disease was initially considered incurable. Nevertheless, through collaborative multi-disciplinary surgical approach, successful resection was achieved. Conclusion: T4 disease exhibits heterogeneity, and although it is typically deemed unresectable, recent developments in surgery are challenging this conventional belief and demonstrating the potential benefits of surgical resection, particularly where a radical dissection is anticipated. http://ijms.info/IJMS/article/view/2516lung cancercardiothoracic surgeryT4locally advancedsurgery |
| spellingShingle | Meadhbh Ni Mhiochain de Grae William P. Duggan Paul Carroll Alan Soo A Case of Successful Surgical Resection of Locally Advanced (T4) Lung Cancer Utilizing a Multi-Disciplinary Approach Involving Previously Unresectable Structures International Journal of Medical Students lung cancer cardiothoracic surgery T4 locally advanced surgery |
| title | A Case of Successful Surgical Resection of Locally Advanced (T4) Lung Cancer Utilizing a Multi-Disciplinary Approach Involving Previously Unresectable Structures |
| title_full | A Case of Successful Surgical Resection of Locally Advanced (T4) Lung Cancer Utilizing a Multi-Disciplinary Approach Involving Previously Unresectable Structures |
| title_fullStr | A Case of Successful Surgical Resection of Locally Advanced (T4) Lung Cancer Utilizing a Multi-Disciplinary Approach Involving Previously Unresectable Structures |
| title_full_unstemmed | A Case of Successful Surgical Resection of Locally Advanced (T4) Lung Cancer Utilizing a Multi-Disciplinary Approach Involving Previously Unresectable Structures |
| title_short | A Case of Successful Surgical Resection of Locally Advanced (T4) Lung Cancer Utilizing a Multi-Disciplinary Approach Involving Previously Unresectable Structures |
| title_sort | case of successful surgical resection of locally advanced t4 lung cancer utilizing a multi disciplinary approach involving previously unresectable structures |
| topic | lung cancer cardiothoracic surgery T4 locally advanced surgery |
| url | http://ijms.info/IJMS/article/view/2516 |
| work_keys_str_mv | AT meadhbhnimhiochaindegrae acaseofsuccessfulsurgicalresectionoflocallyadvancedt4lungcancerutilizingamultidisciplinaryapproachinvolvingpreviouslyunresectablestructures AT williampduggan acaseofsuccessfulsurgicalresectionoflocallyadvancedt4lungcancerutilizingamultidisciplinaryapproachinvolvingpreviouslyunresectablestructures AT paulcarroll acaseofsuccessfulsurgicalresectionoflocallyadvancedt4lungcancerutilizingamultidisciplinaryapproachinvolvingpreviouslyunresectablestructures AT alansoo acaseofsuccessfulsurgicalresectionoflocallyadvancedt4lungcancerutilizingamultidisciplinaryapproachinvolvingpreviouslyunresectablestructures AT meadhbhnimhiochaindegrae caseofsuccessfulsurgicalresectionoflocallyadvancedt4lungcancerutilizingamultidisciplinaryapproachinvolvingpreviouslyunresectablestructures AT williampduggan caseofsuccessfulsurgicalresectionoflocallyadvancedt4lungcancerutilizingamultidisciplinaryapproachinvolvingpreviouslyunresectablestructures AT paulcarroll caseofsuccessfulsurgicalresectionoflocallyadvancedt4lungcancerutilizingamultidisciplinaryapproachinvolvingpreviouslyunresectablestructures AT alansoo caseofsuccessfulsurgicalresectionoflocallyadvancedt4lungcancerutilizingamultidisciplinaryapproachinvolvingpreviouslyunresectablestructures |