Association between CAPN-10 gene variant and diabetes mellitus in Nigeria: a review
Abstract Background Type 2 Diabetes Mellitus (T2DM) is a significant global health concern characterised by insulin resistance and chronic hyperglycemia. Genetic factors, particularly variations in the CAPN-10 gene, have been implicated in T2DM susceptibility across diverse populations. Aim and obje...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2025-02-01
|
| Series: | Egyptian Journal of Medical Human Genetics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43042-025-00655-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823861986841067520 |
|---|---|
| author | David Olufemi Adebo Mathew Folaranmi Olaniyan Christian Onosetale Ugege Odekunle Bola Odegbemi |
| author_facet | David Olufemi Adebo Mathew Folaranmi Olaniyan Christian Onosetale Ugege Odekunle Bola Odegbemi |
| author_sort | David Olufemi Adebo |
| collection | DOAJ |
| description | Abstract Background Type 2 Diabetes Mellitus (T2DM) is a significant global health concern characterised by insulin resistance and chronic hyperglycemia. Genetic factors, particularly variations in the CAPN-10 gene, have been implicated in T2DM susceptibility across diverse populations. Aim and objective This study aimed to conduct a meta-analysis to investigate the associations of single nucleotide polymorphisms (SNPs) in the CAPN-10 gene with T2DM among various populations, focusing specifically on Nigerian cohorts. Materials and methods A comprehensive literature search yielded 150 studies, from which 45 met inclusion criteria, encompassing approximately 25,000 individuals, including 10,000 diagnosed with T2DM. Statistical analyses assessed the association between CAPN-10 SNPs (UCSNP-43, UCSNP-19, UCSNP-63) and T2DM risk. Results A significant association was observed for UCSNP-43 (rs3792267) with T2DM (OR 1.50; 95% CI 1.28–1.75; p < 0.001), particularly in urban Nigerian populations. UCSNP-19 (rs3842570) also showed a moderate association (OR 1.35; 95% CI 1.10–1.66; p = 0.01), especially in South-West Nigeria. No significant association was found for UCSNP-63 (OR 1.15; 95% CI 0.90–1.45; p = 0.30). Conclusion The findings indicate that CAPN-10 SNPs, particularly UCSNP-43 and UCSNP-19, contribute to T2DM susceptibility in Nigerian populations, emphasising the importance of genetic screening for personalised interventions in diabetes management. |
| format | Article |
| id | doaj-art-948e26d069c0419ba55a0db00bb671de |
| institution | Kabale University |
| issn | 2090-2441 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Medical Human Genetics |
| spelling | doaj-art-948e26d069c0419ba55a0db00bb671de2025-02-09T12:40:06ZengSpringerOpenEgyptian Journal of Medical Human Genetics2090-24412025-02-0126111210.1186/s43042-025-00655-1Association between CAPN-10 gene variant and diabetes mellitus in Nigeria: a reviewDavid Olufemi Adebo0Mathew Folaranmi Olaniyan1Christian Onosetale Ugege2Odekunle Bola Odegbemi3Medical Laboratory Science Department, Edo State UniversityMedical Laboratory Science Department, Edo State UniversityMedical Laboratory Science Department, Edo State UniversityMedical Laboratory Science Department, Edo State UniversityAbstract Background Type 2 Diabetes Mellitus (T2DM) is a significant global health concern characterised by insulin resistance and chronic hyperglycemia. Genetic factors, particularly variations in the CAPN-10 gene, have been implicated in T2DM susceptibility across diverse populations. Aim and objective This study aimed to conduct a meta-analysis to investigate the associations of single nucleotide polymorphisms (SNPs) in the CAPN-10 gene with T2DM among various populations, focusing specifically on Nigerian cohorts. Materials and methods A comprehensive literature search yielded 150 studies, from which 45 met inclusion criteria, encompassing approximately 25,000 individuals, including 10,000 diagnosed with T2DM. Statistical analyses assessed the association between CAPN-10 SNPs (UCSNP-43, UCSNP-19, UCSNP-63) and T2DM risk. Results A significant association was observed for UCSNP-43 (rs3792267) with T2DM (OR 1.50; 95% CI 1.28–1.75; p < 0.001), particularly in urban Nigerian populations. UCSNP-19 (rs3842570) also showed a moderate association (OR 1.35; 95% CI 1.10–1.66; p = 0.01), especially in South-West Nigeria. No significant association was found for UCSNP-63 (OR 1.15; 95% CI 0.90–1.45; p = 0.30). Conclusion The findings indicate that CAPN-10 SNPs, particularly UCSNP-43 and UCSNP-19, contribute to T2DM susceptibility in Nigerian populations, emphasising the importance of genetic screening for personalised interventions in diabetes management.https://doi.org/10.1186/s43042-025-00655-1Type 2 diabetes mellitusCAPN-10Single nucleotide polymorphismsGenetic susceptibilityNigeriaMeta-analysis |
| spellingShingle | David Olufemi Adebo Mathew Folaranmi Olaniyan Christian Onosetale Ugege Odekunle Bola Odegbemi Association between CAPN-10 gene variant and diabetes mellitus in Nigeria: a review Egyptian Journal of Medical Human Genetics Type 2 diabetes mellitus CAPN-10 Single nucleotide polymorphisms Genetic susceptibility Nigeria Meta-analysis |
| title | Association between CAPN-10 gene variant and diabetes mellitus in Nigeria: a review |
| title_full | Association between CAPN-10 gene variant and diabetes mellitus in Nigeria: a review |
| title_fullStr | Association between CAPN-10 gene variant and diabetes mellitus in Nigeria: a review |
| title_full_unstemmed | Association between CAPN-10 gene variant and diabetes mellitus in Nigeria: a review |
| title_short | Association between CAPN-10 gene variant and diabetes mellitus in Nigeria: a review |
| title_sort | association between capn 10 gene variant and diabetes mellitus in nigeria a review |
| topic | Type 2 diabetes mellitus CAPN-10 Single nucleotide polymorphisms Genetic susceptibility Nigeria Meta-analysis |
| url | https://doi.org/10.1186/s43042-025-00655-1 |
| work_keys_str_mv | AT davidolufemiadebo associationbetweencapn10genevariantanddiabetesmellitusinnigeriaareview AT mathewfolaranmiolaniyan associationbetweencapn10genevariantanddiabetesmellitusinnigeriaareview AT christianonosetaleugege associationbetweencapn10genevariantanddiabetesmellitusinnigeriaareview AT odekunlebolaodegbemi associationbetweencapn10genevariantanddiabetesmellitusinnigeriaareview |