The anti-apoptotic function of HSV-1 LAT in neuronal cell cultures but not its function during reactivation correlates with expression of two small non-coding RNAs, sncRNA1&2.

Multiple functions are associated with HSV-1 latency associated transcript (LAT), including establishment of latency, virus reactivation, and antiapoptotic activity. LAT encodes two sncRNAs that are not miRNAs and previously it was shown that they have antiapoptotic activity in vitro. To determine i...

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Bibliographic Details
Main Authors: Jay J Oh, Ujjaldeep Jaggi, Kati Tormanen, Shaohui Wang, Satoshi Hirose, Homayon Ghiasi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012307
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